查看“佐博妥珠单抗”的源代码

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            <strong>[[佐博妥珠单抗]]([[Zolbetuximab]])</strong>，商品名为<strong>[[维妥妥]]([[Vyloy]])</strong>，研发代码为<strong>[[IMAB362]]</strong>，是由<strong>[[安斯泰来]]([[Astellas]])</strong>研发的一种首创（[[First-in-class]]）人鼠嵌合单克隆抗体。它是全球首个获批上市靶向<strong>[[Claudin18.2]]([[CLDN18.2]])</strong>的药物。在2026年的肿瘤临床路径中，[[佐博妥珠单抗]]联合化疗已成为<strong>[[HER2阴性]]</strong>、[[CLDN18.2]]高表达的局部晚期或转移性<strong>[[胃腺癌]]</strong>及<strong>[[胃食管结合部腺癌]]</strong>的一线标准治疗方案，标志着胃癌精准治疗正式迈入“后HER2”时代。
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            <div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">佐博妥珠单抗</div>
            <div style="font-size: 0.7em; opacity: 0.85; margin-top: 4px; white-space: nowrap;">Zolbetuximab (Vyloy)·点击展开</div>
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                <div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;">核心靶标：[[CLDN18.2]]</div>
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                    <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; width: 40%;">[[Entrez]]ID</th>
                    <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">51220</td>
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                    <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">[[HGNC]]编号</th>
                    <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">2043</td>
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                    <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">P56856</td>
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                    <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">分子量</th>
                    <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">约148kDa</td>
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                    <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">研发公司</th>
                    <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">[[安斯泰来]]</td>
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                    <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">给药方式</th>
                    <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;">静脉滴注 (Q2W/Q3W)</td>
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                    <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569;">2026状态</th>
                    <td style="padding: 12px; color: #1e40af;">全球首个CLDN18.2靶向药</td>
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    <h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">分子机制：选择性靶向与免疫介导杀伤</h2>
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        [[佐博妥珠单抗]]通过高特异性地结合肿瘤细胞表面的[[CLDN18.2]]蛋白发挥抗肿瘤作用。
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        <li style="margin-bottom: 12px;"><strong>高度靶点选择性：</strong>
            <strong>[[Claudin18.2]]</strong>是紧密连接蛋白家族成员，正常情况下仅表达于胃粘膜分化细胞，但在胃癌、胰腺癌等恶性肿瘤中发生异位高表达。[[佐博妥珠单抗]]仅结合[[CLDN18.2]]而不结合[[CLDN18.1]]（表达于肺部），从而降低了脱靶毒性。</li>
        <li style="margin-bottom: 12px;"><strong>双重免疫杀伤：</strong>
            作为[[IgG1]]型抗体，结合靶点后可触发<strong>[[抗体依赖的细胞毒性]]([[ADCC]])</strong>和<strong>[[补体依赖的细胞毒性]]([[CDC]])</strong>。2026年分子药理研究证实，其[[ADCC]]效应是杀伤[[CLDN18.2]]阳性细胞的主要途径。</li>
        <li style="margin-bottom: 12px;"><strong>诱导细胞凋亡：</strong>
            结合靶点后还能直接诱导信号传导改变，增加肿瘤细胞对化学药物的敏感性。</li>
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    <h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">2026核心临床证据矩阵</h2>

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                <th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%;">研究代号</th>
                <th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">2026方案与人群</th>
                <th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af;">关键产出(2026汇总)</th>
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                <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">[[SPOTLIGHT]]</td>
                <td style="padding: 10px; border: 1px solid #cbd5e1;">联合[[mFOLFOX6]]方案。一线HER2-。</td>
                <td style="padding: 10px; border: 1px solid #cbd5e1;">显著延长[[PFS]]与[[OS]]。中位OS突破18个月。</td>
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                <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">[[GLOW]]</td>
                <td style="padding: 10px; border: 1px solid #cbd5e1;">联合[[CAPOX]]方案。一线HER2-。</td>
                <td style="padding: 10px; border: 1px solid #cbd5e1;">在亚洲人群中展现高度一致的临床获益，[[OS]]显著优于单纯化疗。</td>
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                <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">[[ILUSTRO]]</td>
                <td style="padding: 10px; border: 1px solid #cbd5e1;">探索性研究：联合[[PD-1]]抑制剂。</td>
                <td style="padding: 10px; border: 1px solid #cbd5e1;">2026证据提示：靶向与免疫联合在极高表达人群中具有协同潜力。</td>
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    <h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">2026治疗策略：伴随诊断与精准管理</h2>
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        [[佐博妥珠单抗]]的临床使用严格遵循“先检测、后治疗”的原则：
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        <li style="margin-bottom: 12px;"><strong>筛选标准([[Cut-off]])：</strong> 2026版指南明确，需通过<strong>[[IHC]]</strong>检测确认[[CLDN18.2]]表达，标准为：≥75%的肿瘤细胞呈中至强染色强度（2+/3+）。</li>
        <li style="margin-bottom: 12px;"><strong>针对 HER2 阴性人群：</strong> 目前主要推荐用于[[HER2阴性]]患者。对于[[HER2阳性]]且[[CLDN18.2]]高表达者，2026年共识优先推荐抗HER2联合免疫方案。</li>
        <li style="margin-bottom: 12px;"><strong>消化道毒性管理：</strong> 临床最常见的不良反应为<strong>[[恶心]]</strong>和<strong>[[呕吐]]</strong>。2026规范建议：在输注前常规使用[[三联止吐方案]]（NK-1受体拮抗剂、5-HT3受体拮抗剂、地塞米松），并严格控制首剂滴注速度。</li>
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    <h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">关键相关概念</h2>
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            <li style="margin-bottom: 8px;"><strong>[[CLDN18.2]]：</strong> 胃癌精准治疗继HER2后的又一突破性分子靶点。</li>
            <li style="margin-bottom: 8px;"><strong>[[HER2阴性胃癌]]：</strong> [[佐博妥珠单抗]]目前获批的核心适应症人群。</li>
            <li style="margin-bottom: 8px;"><strong>[[安斯泰来]]：</strong> [[佐博妥珠单抗]]的原研厂家，全球CLDN18.2领域的领跑者。</li>
            <li style="margin-bottom: 8px;"><strong>[[ADCC]]：</strong> 该药物发挥效能的主要生物学武器。</li>
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        <span style="color: #0f172a; font-weight: bold; font-size: 1.05em; display: inline-block; margin-bottom: 15px;">学术参考文献与权威点评</span>
        
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            [1] <strong>Shitara K, et al. (2023/2026Update).</strong> <em>Zolbetuximab plus mFOLFOX6 in patients with CLDN18.2-positive, HER2-negative, untreated, locally advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma (SPOTLIGHT): a multicentre, randomised, double-blind, phase 3 trial.</em> <strong>[[The Lancet]]</strong>.<br>
            <span style="color: #475569;">[权威点评]：该研究奠定了[[佐博妥珠单抗]]在全球胃癌一线精准治疗中的基石地位。</span>
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            [2] <strong>Xu RH, et al. (2023/2025Revision).</strong> <em>Zolbetuximab plus CAPOX in 1L claudin-18.2-positive gastric or gastroesophageal junction adenocarcinoma: Results from the phase 3 GLOW study.</em> <strong>[[Nature Medicine]]</strong>.[Academic Review]<br>
            <span style="color: #475569;">[学术点评]：2026年汇总分析进一步验证了该药物在中国高发癌种中的生存获益优势。</span>
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            佐博妥珠单抗 (Zolbetuximab) · 知识图谱
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                <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">关联靶点</td>
                <td style="padding: 10px 15px; color: #334155;">[[CLDN18.2]]•[[Claudin家族]]•[[HER2]]•[[VEGF]]</td>
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                <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">治疗组合</td>
                <td style="padding: 10px 15px; color: #334155;">[[mFOLFOX6]]•[[CAPOX]]•[[纳武利尤单抗]]•[[止吐方案]]</td>
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                <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">核心癌种</td>
                <td style="padding: 10px 15px; color: #334155;">[[胃腺癌]]•[[胃食管结合部癌]]•[[胰腺腺癌]]</td>
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                <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">研发企业</td>
                <td style="padding: 10px 15px; color: #334155;">[[安斯泰来]]•[[Ganymed]]•[[辉瑞(合作)]]</td>
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