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Blindness,lowvision,andotherhandicapsasriskfactorsattachedtoinstitutionalresidence
1H?pitalCochin-UniversitéParis5,Serviced’Ophtalmologie,24rueduFaubourgSaintJacques,F-75014Paris,France2Cemka,43,BoulevardduMaréchalJoffre,F-92340Bourg-la-Reine,France3UniversitédeBretagneSud.RueYvesMainguy,CampusdeTohannic,F-56000Vannes,FranceABSTRACTAims:Toestimatetheriskoflivinginaninstitutio...
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“Viraldéjàvu“elicitsorgan-specificimmunediseaseindependentofreactivitytoself
...pesharedbytheprecipitatingvirusandthepredisposingviruspersistinginneurons(déjàvu).Thustheconceptof“viraldéjàvu“demonstrateshow2relatedbutindependentlyencounteredviralinfectionscancauseorgan-specificimmunediseasewithoutmolecularmimicryofselfandwithoutbreakingselftolerance.IntroductionTheinfec...
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HighfrequencyofantitumorTcellsinthebloodofmelanomapatientsbeforeandaftervaccinationwithtumorantigens
1CellularGeneticsUnit,UniversitédeLouvain,B-1200Brussels,Belgium2LudwigInstituteforCancerResearch,BrusselsBranch,B-1200Brussels,Belgium3MedicalOncology,ErasmeHospital,B-1070Brussels,BelgiumAftervaccinationofmelanomapatientswithMAGEantigens,weobservedthateveninthefewpatientsshowingtumorregression,th...
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基因分析表明鲨鱼的种类或超出估计
...的一种，应该与传统的分类法联合起来使用。 XimenaVélez-Zuazo是美国波多黎各大学的生物学家，曾在2011年发表了一片文章。Naylor认为，由于只采用了分子信息，这篇文章存在着一些缺陷。虽然Vélez-Zuazo坚决捍卫自己的研究成...
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GenomicAnalysisofMycobacteriumtuberculosisComplexStrainsUsedforProductionofPurifiedProteinDerivative
...bypassagethroughartificialmediahasparallelswiththemethodusedbyCalmetteandGuérintoattenuateastrainofM.bovistogenerateM.bovisBCG(3).Byusinggenomictechnologies,ithasbeenshownthatduringthisinvitroculturethegenomeofBCGsufferedanumberofgenedeletionsandchromosomalrearrangements(1,2).Hence,itispossiblethat...
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ContributionofDNApolymerasetoimmunoglobulingenehypermutationinthemouse
InstitutNationaldelaSantéetdelaRechercheMedicaleU373,FacultédeMédecineNecker-EnfantsMalades-UniversitéParisV,75730ParisCedex15,FranceThemutationpatternofimmunoglobulingeneswasstudiedinmicedeficientforDNApolymerase,atranslesionalpolymerasewhoseinactivationisresponsibleforthexerodermapigmentosumva...
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ProphylaxisofThromboticandEmbolicEventsinAcuteIschemicStrokeWiththeLow-Molecular-WeightHeparinCertoparin
...Küppers-Tiedt,A.Lmmer,D.Pfeiffer;HospitalChemnitz:J.K.,J.J.Schwarze;CharitéBerlin,CampusMitte:L.Harms,N.Amberger,F.Lürtzing,H.Jepsen;HospitalBadNeustadt/Saale:B.Griewing,(0)2H.Sodan;HospitalFriedrichshain,Berlin:M.Klein,D.Berfelde,A.Holle,H.-P.Dahse;HospitalAltenburg:J.Berrouschot,O.Niederstrasse...
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ComparisonoftheBordetellapertussisandBordetellaparapertussisIsolatesCirculatinginSaintPetersburgbetween1998and2000withRussianVaccineStrain
...urInstituteofEpidemiologyandMicrobiology,197101SaintPetersburg,Russia,1UnitédesBordetella,InstitutPasteur,75724ParisCedex15,France,2BacterialVaccinesControlandStandardizationLaboratory,L.A.TarassevichStateControlandStandardizationInstitute,121002Moscow,Russia3Received10February2003/Returnedformodif...
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TypeIInterferonProductionIsProfoundlyandTransientlyImpairedinPrimaryHIV-1Infection
InstitutCochin,Départementd‘Immunologie,INSERMU,CentreNationaldelaRechercheScientifique,UMR,IFR,UniversitéParisVRenéDescartesFacultédeMédecine,IFR,UniversitéRenéDescartes,ParisINSERMU,CohortePRIMOAgenceNationaledeRecherchecontreleSida,ServicedeMédecineInterne,HpitaldeBicêtreUnitéINSERME,...
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NovelStableCamptothecinDerivativesReplacingtheE-RingLactonebyaKetoneFunctionArePotentInhibitorsofTopoisomeraseIandPromisingAntitumorDrugs
...BiolChem278:20303-20312.[Abstract/FreeFullText]HautefayeP,CimetièreB,PierréA,LeonceS,HickmanJ,LaineW,BaillyC,andLavielleG(2003)SynthesisandpharmacologicalevaluationofnovelE-ringnon-lactoneanaloguesofcamptothecin.BioorgMedChemLett13:2731-2735.[CrossRef][Medline]HertzbergRP,CaranfaMJ,HoldenKG,JakasD...
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TheimmuneparadoxofsarcoidosisandregulatoryTcells
1InstitutNationaldelaSantéetdelaRechercheMédicale(INSERM)U543,ImmunologieAandInternalMedicineDepartment,AP-HPHpitalPitié-Salpêtrière,75013Paris,France2UniversitéPierreetMarieCurie-Paris6,75005Paris,France3INSERMU255,CentredeRecherchesBiomédicalesdesCordeliers,75006Paris,France4PneumologyDepar...
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CD4+CD25+regulatoryTcellsinhibitnaturalkillercellfunctionsinatransforminggrowthfactor––dependentmanner
1ERM0208,InstitutNationaldelaSantéetdelaRechercheMédicale(INSERM),UniversityofParisXI2Unitéd‘Immunothérapie,U362,InstitutGustaveRoussy,94805Villejuif,France3DepartmentofMedicalOncology,U362,InstitutGustaveRoussy,94805Villejuif,France4INSERM,U362,InstitutGustaveRoussy,94805Villejuif,France5INSE...
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OxygenGlucoseDeprivationSwitchestheTransportoftPAAcrosstheBlood–BrainBarrierFromanLRP-DependenttoanIncreasedLRP-IndependentProcess
INSERM-Avenir(K.B.,D.V.,C.A.),CentreCyceron,UniversitédeCaen,FranceCNRSUMR6185(K.B.,M.F.-M.,S.V.,O.T.),UniversitédeCaen,CentreCyceron,FranceLaboratoiredePhysiopathologiedelaBarrièreHémato-Encéphalique(V.B.,J.B.,M.-P.D.,R.C.),EA2465,Universitéd’Artois,FacultédessciencesJeanPerrin,FrancetheDe...
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CombinationofHIV-1SpecificCD4Th1CellResponsesandIgG2AntibodiesIstheBestPredictorforPersistenceofLong-TermNonprogression
...laireetTissulaire,INSERMU,INSERMEMILaboratoiredeVirologie,UPRESEA,UniversitéPierreetMarieCurie,HpitalPitié-SalpêtrièreLaboratoiredeVirologie,HpitalNecker-EnfantsMalades,Serviced‘Immuno-Hématologie,HpitalSaint-LouisServicedeMédecineInterne,HpitalCochin,Paris,FranceBackground.StrongTcellandant...
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IncreasedvaccineefficacyagainsttuberculosisofrecombinantMycobacteriumbovisbacilleCalmette-Guérinmutantsthatsecretelisteriolysin
...ondonSchoolofHygieneandTropicalMedicine,London,UnitedKingdom.3INSERM,FacultédeMédecineNecker-EnfantsMalades,Paris,France.4NationalMycobacteriaReferenceLaboratory,NationalInstituteofPublicHealthandtheEnvironment,Bilthoven,TheNetherlands.AbstractThetuberculosisvaccineMycobacteriumbovisbacilleCalmett...
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Brainglucagon-likepeptide–1increasesinsulinsecretionandmuscleinsulinresistancetofavorhepaticglycogenstorage
1UMR5018,UniversitéPaulSabatier,IFR31,Toulouse,France.2UnitédePharmacocinétique,Métabolisme,NutritionetToxicology,UniversitéCatholiquedeLouvain,Brussels,Belgium.3InstitutCochin,INSERMU567UMR8104,UniversitéRenéDescartes,Départementd’Endocrinologie,Paris,France.4INSERM568,IFR50,FacultédeMé...
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HTLV-1propelsuntransformedCD4+lymphocytesintothecellcyclewhileprotectingCD8+cellsfromdeath
1OncovirologieetBiothérapies,CNRSUMR5537—UniversitéClaudeBernard,CentreLéonBérard,Lyon,France.2Serviced’Hématologie,H?pitalEdouardHerriot,Lyon,France.3Laboratoired’Hématologie,CentreHospitalierUniversitaire(CHU)d’Angers,Angers,France.4Laboratoired’Immunologie,CHUHenriMondor,Créteil,...
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DefectiveNKTcelldevelopmentinmiceandhumanslackingtheadapterSAP,theX-linkedlymphoproliferativesyndromegeneproduct
1LaboratoireduDéveloppementNormaletPathologiqueduSystèmeImmunitaire,UnitéINSERM4292Centred‘étudedesDéficitsImmunitaires,HpitalNeckerEnfants-Malades,75015Paris,France3Unitéd‘Immunologie-HématologiePédiatrique,HpitalNeckerEnfants-Malades,75015Paris,France4InternationalAgencyforResearchonCa...
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Repertoire,diversity,anddifferentiationofspecificCD8Tcellsareassociatedwithimmuneprotectionagainsthumancytomegalovirusdisease
...SERMU5432Serviced‘Ophtalmologie,EA23873LaboratoiredeVirologie,EA23874Unitéd‘EpidémiologieCliniqueetTraitementsdel‘InfectionVIH,INSERMU7205ServicedeMédecineInterne,HpitalPitié-Salpétrière,UniversitéPierreetMarieCurie,75013Paris,France6ServicedesMaladiesInfectieuses,HpitalPitié-Salpétri...
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EvaluationoftheOsirisExpertSystemforIdentificationofß-LactamPhenotypesinIsolatesofPseudomonasaeruginosa
...,75020Paris,2Bio-Rad,92430Marnes-la-Coquette,3ServicedeMicrobiologie,FacultédePharmacie,UniversitédeBordeaux2,33076Bordeauxcedex,France4Received25April2002/Returnedformodification25September2002/Accepted17March2003 ABSTRACTTopAbstractIntroductionMaterialsandMethodsResultsDiscussionReferencesOsir...
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CultureofTropherymawhippleifromHumanSamples:a3-YearExperience(1999to2002)
UnitédesRickettsies,CNRSUMR6020,IFR48,FacultédeMédecine,UniversitédelaMéditerranée,13385Marseillecedex05,1LaboratoiredeMicrobiologie,HôpitalLouisPradel,69394LyonCedex03,France2Received16January2003/Returnedformodification4April2003/Accepted21April2003 ABSTRACTTopAbstractIntroductionMat...
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SharedreactivityofV2negTcellsagainstcytomegalovirus-infectedcellsandtumorintestinalepithelialcells
1UMR5164,CentreNationaldelaRechercheScientifique(CNRS),IFR66,UniversitéBordeaux2,33076Bordeaux,France2LudwikHirszfeldInstituteofImmunologyandExperimentalTherapy,PolishAcademyofSciences,53114Wroclaw,Poland3InstitutNationaldelaSantéetdelaRechercheMedicale(INSERM)U131,92140Clamart,France4INSERMU725,E...
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Contrastingfrequenciesofantitumorandanti-vaccineTcellsinmetastasesofamelanomapatientvaccinatedwithaMAGEtumorantigen
1CellularGeneticsUnit,UniversitédeLouvain,B-1200Brussels,Belgium2DepartmentofPathology,UniversitédeLouvain,B-1200Brussels,Belgium3LudwigInstituteforCancerResearch,BrusselsBranch,B-1200Brussels,BelgiumMelanomapatientshavehighfrequenciesofTcellsdirectedagainstantigensoftheirtumor.Thefrequencyofthese...
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Leukocyte-DerivedInterleukin10IsRequiredforProtectionAgainstAtherosclerosisinLow-DensityLipoproteinReceptorKnockoutMice
FromtheInstitutNationaldelaSantéetdelaRechercheMédicale,(INSERM)U541(S.P.,B.E.,O.V.O.,A.T.,Z.M.),InstitutFédératifdeRecherche“CirculationParisVII,“H?pitalLariboisière,Paris,France;TxCell,Bat.ARC(V.B.)andINSERMU576(V.B.,H.G.),H?pitaldel’Archet,Nice,France;andInstitutGustaveRoussy(P.A.),Vil...
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InvivocorrectionofZAP-70immunodeficiencybyintrathymicgenetransfer
1InstitutdeGénétiqueMoléculairedeMontpellier,CNRSUMR5535/InstitutFédératifdeRecherch122,Montpellier,France.2UniversitéPierreetMarieCurie/CNRSUMR7087,H?pitalPitié-Salpêtrière,Paris,France.AbstractSCIDpatientshavebeensuccessfullytreatedbyadministrationofexvivogene-correctedstemcells.However,d...
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SimplificationTherapywithOnce-DailyEmtricitabine,Didanosine,andEfavirenzinHIV-1InfectedAdultswithViralSuppressionReceivingaProteaseInhibitorB
Assistance-PubliqueHpitauxdeParis,Paris,InstitutNationaldelaSantéetdelaRechercheMédicaleUBordeauxHpitalSaint-André,Bordeaux,Hpitaldel‘Archet,NiceHpitalSainteMarguerite,Marseille,FranceBackground.Weassessedaonce-dailycombinationtosimplifytherapyinpatientsinfectedwithhumanimmunodeficiencyvirustyp...
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StaphylococcusaureusPanton-ValentineleukocidindirectlytargetsmitochondriaandinducesBax-independentapoptosisofhumanneutrophils
1CentreNationaldeRéférencedesStaphylocoques,INSERME0230,Lyon,France.2INSERMU503,BiosciencesLyonGerland,Lyon,France.3LaboratoiredePhysiopathologieetd’AntibiologiedesInfectionsBactériennesEmergentesetNosocomiales–EA3432,InstitutdeBactériologiedelaFacultédeMédecine–H?pitauxUniversitairesdeS...
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Intestinalantiinflammatoryeffectof5-aminosalicylicacidisdependentonperoxisomeproliferator–activatedreceptor-
1InstitutNationaldelaSantéetdelaRechercheMedicale(INSERM)0114,PhysiopathologiedesMaladiesInflammatoiresIntestinales,CHU59037Lille,France2INSERMU459,FacultédeMédecine,59045LilleCedex,France3InstitutdeGénétiqueetBiologieMoléculaireetCellulaire,INSERM,CentreNationaldelaRechercheScientifique,Unive...
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Clinicalfeaturesofdrusenoidpigmentepithelialdetachmentinagerelatedmaculardegeneration
1CliniqueOphtalmologiqueUniversitairedeCréteil,France2ServiceSantéPubliqueHopitalHenri-MondorCréteil,FranceCorrespondenceto:DrGSoubraneCliniqueOphtalmologiqueUniversitairedeCréteil,40avenuedeVerdun,94200Créteil,France;gisele.soubrane@chicreteil.frAcceptedforpublication15September2003ABSTRACTAim...
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DirectcleavageofROCKIIbygranzymeBinducestargetcellmembraneblebbinginacaspase-independentmanner
1InstitutNationaldelaSantéetdelaRechercheMedicale(INSERM)U461,IFR75,FacultédePharmacie,92296Chatenay-Malabry,France2INSERMU517,FacultédeMédecineetdePharmacie,21079Dijon,FranceCaspaseactivationintargetcellsisamajorfunctionofgranzymeB(grB)duringcytotoxiclymphocytegranule-inducedapoptosis.grB-media...