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心肌梗死后室性期前收缩与心脏性猝死的预测
为探讨心肌梗死后室性期前收缩（以下简称VPC）与心脏性猝死的关系，预测可能发生的致命危险，以求及早防治，我们对9年来我院收治的124例心肌梗死患者进行定期监测，并作了随访，现将结果报道如下。 1临床资料 1.1...
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胺碘酮在室性心律失常中的应用
...0～76岁。入选标准:（1）患者有慢性心衰病史，LVEF40%，且VPC10/h;（2）排除窦性心动过缓、窦房阻滞、束支传导阻滞及其他高度传导障碍者（安置起搏器者除外）;排除各种原因引起的低血压者（收缩压90mmHg）;排除甲状腺功能障碍...
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Selectivesphingosine1-phosphate1receptoractivationreducesischemia-reperfusioninjuryinmousekidney
...lydecreasedwithFTY-720treatment.TheprotectiveeffectofFTY-720wasreversedwithVPC-44116,aselectiveS1P1receptorantagonist.Furthermore,SEW-2871,aselectiveS1P1agonist,significantlydecreasedplasmacreatinineinadose-responsemannerwithamaximalreductionof70%withadoseof10mg/kg.Analysisofkidneysbylightmicroscopy...
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比索洛尔治疗充血性心力衰竭并发室性心律失常临床观察
...能（NYHA）Ⅲ～Ⅳ级，左心室射血分数0.4;频发室性早搏（VPC）34例，阵发性室性心动过速（PVT）2例，合并Ⅰ度房室传导阻滞2例。无Ⅱ度以上房室传导阻滞、病态窒房结综合征、窦性心动过缓及QTc0.50者，无严重的肺部疾病和肝病...
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胺碘酮治疗充血性心力衰竭并发室性心律失常临床观察
...能（NYHA）Ⅲ～Ⅳ级，左心室射血分数0.40;频发室性早搏（VPC）36例，阵发性室性心动过速（PVT）2例，合并Ⅰ度房室传导阻滞2例。无Ⅱ度以上房室传导阻滞、病态窦房结综合征、窦性心动过缓及QTc0.50s、严重肺部疾病和肝病、甲状...
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重组逆转录病毒载体介导基因转移的现状及思考
...障的存在，使得向肿瘤部位注射的外源性病毒生产细胞（VPC）可长期存活。理想的基因转染方法是在肿瘤局部环境中连续不断的提供载体质粒来转染周围的肿瘤细胞，基于这一构想，有学者在基因治疗肿瘤的实验中建立了将肿瘤...
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RegulationofLysophosphatidicAcidReceptorExpressionandFunctioninHumanSynoviocytes:ImplicationsforRheumatoidArthritis?
...o-(2-octadec-9-enoylamino-3-[4-(pyridine-2-ylmethoxy)-phenyl]-propyl)ester(VPC32183).Signaltransductionthroughp42/44mitogen-activatedproteinkinase(MAPK),p38MAPK,andRhokinaseisinvolvedinLPA-mediatedcytokinesecretion,whereasLPA-inducedcellmotilityrequiresp38MAPKandRhokinasebutnotp42/44MAPK.Treatmentof...
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SphingosineKinase-DependentActivationofEndothelialNitricOxideSynthasebyAngiotensinII
...lresponsesamountedto2.6±0.2mN/mmsegmentlength.DMS(10µmol/L)andVPC23019(10µmol/L)hadnoinfluenceonthepretensionofthepreparations.PreincubationofthevesselswithDMS(10µmol/L)hadnosignificanteffectonthepotencyorefficacyofKClorphenylephrine(Figure1Aand1B).However,DMSinducedaleftwar...
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Synthesisoflong-chainpolyunsaturatedfattyacidsinpretermnewbornsfedformulawithlong-chainpolyunsaturatedfattyacids
...uteofMaternal-InfantileSciences,PolytechnicUniversityofMarche,Ancona,Italy(VPC);theDepartmentofPediatrics,UniversityofPadua,Padua,Italy(MS,GV,andPEC);theLaboratoryofBiochemistry,ErasmusUniversity,Rotterdam,Netherlands(IL);theDepartmentofGynecology,PerinatologyandChildHealth,LaSapienzaUniversity,Rome...
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胺碘酮治疗器质性心脏病并发室性心律失常或心房颤动的临床观察
...间期的改变，本组30例入选患者的心功能均改善1级，频繁VPC8例的治疗有效率90%，2例PVT也被终止，且心功能迅速改善；房颤治疗有效率90%，无效10%；心室率自（97.57±14.46）/min减至（62.5±9.25）/min，P0.01；Q-T间期从（398.6±21）ms延长...
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肥厚性梗阻型心肌病误诊1例分析
...浮肿至膝关节。ECG:阵发性房颤、房扑，Ⅱ°Ⅰ型AVB，频发VPC，Ⅱ°Ⅱ型SAB。X-线胸片示心影增大。入院后心脏彩超示:（1）左房内径明显增大，左室内径正常，左室室间隔于二尖瓣水平以下至乳头肌水平明显肥厚约21mm，左室侧壁...
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等离子体技术及临床应用
...割（PK）模式;另一种是在腹腔镜下操作的脉冲凝血切割（VPC）模式。当等离子体能量控制器输出切割能量时，因工作点能量集中，高聚焦，作用局限，因此切割精确;同时因适中的电压及电流，靶组织表面温度在40℃～70℃［2］。...
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30例老年患者心脏性猝死前动态心电图分析
...CHD）and≥3gradeventriculararrhythmia（ventricularprematurecomplexes，VPC）intheCSDgroupwerehigherthaninthecontrolgroup（P0.05）;②TheincidenceofatrialfibrillationintheCSDgroupwerehigherthaninthecontrolgroup（P0.05）;③Theincidenceofmyocardialischemia（MI）andpersistencedepressionofSTse...
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Sphingosine-1-PhosphatePreventsTumorNecrosisFactor-–MediatedMonocyteAdhesiontoAorticEndotheliuminMice
...eS1P1/S1P3Gireceptorsignaling.14Someaortasweretreatedfor4hourswith10μmol/LVPC23019aS1PreceptorantagonistwithaKiforS1P1of25nM;themoleculeis50-foldlesspotentinblockingS1P3,butisinactiveatS1P2.15Aortaswereincubatedwithfluorescentlylabeledmousemonocytesaspreviouslydescribed.16InjectionofSEW2871entirely...
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BroadlyReactiveNestedReverseTranscription-PCRUsinganInternalRNAStandardControlforDetectionofNorovirusesinStoolSamples
...ththenumberoflatexbeads(LB)counted(LBC)pergridandthenumberofvirionscounted(VPC)pergrid,usingtheequationadaptedfromthatdescribedbyMitterederetal.(27),v=(VPC/LBC)x(4.73x1013LBml–1/LBd)x3/μ,whereLBdisthedilutionfactoroflatexbeadsinthemixtureforthegridandμistheconcentrationfactorofthefecalsampleafte...
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DifferentiallocalizationofmammalianLin-7(MALS/Veli)PDZproteinsinthekidney
...ceptortyrosinekinase,Let-23,onthebasolateralmembraneofvulvaprogenitorcells(VPC).NullmutationsinLin-7,Lin-2,orLin-10causetheLet-23receptortobecomemislocalizedtotheapicalmembraneanddisruptVPCdevelopment.StudiestodeducethemechanismrevealedthatLin-7servestheprimaryroleinlocalizingLet-23.Thissmallprotein...
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Invivodeterminationofdiffusivetransportparametersinasuperfusedtissue
...)andsolutionintheperitonealcavity(PC;CPC)aresampled,andtheperitonealvolume(VPC)aremeasured.Themasstransferareacoefficient(MTAC),whichcombinesallofthediffusivetransportprocessesintoasingle“lumped“parameter,characterizesthesolutetransportinthemembranemodel.Thefollowingequationillustratestheuseofth...
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InSilicoPredictionofPregnaneXReceptorActivatorsbyMachineLearningApproache
...bonds(nrot),molecularconnectivityandgeometry(3C,4PC,5CH,6CH,1v,2v,3vP,3vC,4vPC,6vCH,dis1,dis2,dis3,etc.),molecularflexibility(),electrotopologicalstatesorEstates[Scar,Shet,Shal,S(1),S(5),S(12),S(13),S(16),S(18),Tcent,Tradi,Tdiam,Tiwie,etc.],molecularsurfacearea(polarmolecularsurfacearea,Sapc,Sanc,Sa...
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Regulationofcalciumsignalingbypolycystin-
...undinpre-medialGolgiandtheER,bycellgradientanalysis.Whilefull-lengthandD511VPC2wereconfinedtopre-medialGolgimembranes,theL703XPC2partiallytranslocatedtotheplasmamembraneasexpectedfromthelossoftheERretentionsignal(77).ReconstitutedERmembranesfromLLC-PK1cellsoverexpressingwild-typePC2butnotnaïvem...