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美国生命治疗公司启动肝稳定性临床试验
...将有20家来自美国和欧洲的领先肝脏学术机构会参与此次SILVER(StabilizationInLiVERdisease)研究。SILVER治疗方案要求入组病人患有慢性肝病,并且根据终末期肝病评分模型(MELD)的标准,最近曾有过急性发作,并出现过慢加急肝衰竭现象...
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美国生命治疗公司启动肝稳定性临床试验
...将有20家来自美国和欧洲的领先肝脏学术机构会参与此次SILVER(StabilizationInLiVERdisease)研究。SILVER治疗方案要求入组病人患有慢性肝病,并且根据终末期肝病评分模型(MELD)的标准,最近曾有过急性发作,并出现过慢加急肝衰竭现象...
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Science热议,梦魇照进现实?
...cience杂志消息,美国知名学府普林斯顿大学的遗传学家LeeSilver与AnneMorriss成立了一家名为GenePeeks的公司。该公司旨在依据父母的DNA预测其虚拟后代的患病风险,以提高父母怀上健康后代的几率。该公司的计划于十月三日被公布在...
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交流诊疗技术推动足踝外科发展——全国足踝部疾病诊断及治疗研讨学习班在京举办
...疗采用各种第一跖骨截骨术恢复正常的IMA为主,同时进行Silver软组织手术;对于PASA(近端关节固定角)增大,其他角正常的,治疗以恢复正常PASA为主,适宜采用Reverdin或者Austin,同时加用Silver软组织手术;对于单纯的HVA(拇外翻角)...
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Nature重大成果:瘫痪康复或指日可待
...究的高级研究员、凯斯西储大学医学院神经科学教授JerrySilver说:“对于数百万的人们有可能在某一天能够重获脊髓损伤过程中丧失的运动能力,我们感到非常的兴奋。”每年,有成千上万的人因脊髓损伤而瘫痪。损伤挤压并切...
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美国发现脂肪储存重要基因
...方法。 美国纽约艾伯特#8226;爱因斯坦医学院的DavidL.Silver博士说,因为在所有的真核细胞生命中,从最简单的酵母到最复杂的人类,细胞内脂肪滴储存脂肪的能力都是最基本的过程,所以我们试图寻找编码与脂肪储存相关蛋...
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PNAS惊人发现:以癌克癌,循环肿瘤细胞“再立功”
...,并揭示了在小鼠模型中的检测结果。通过向血液中注射silver-bullet对抗癌症一直是科学家们的研究方向之一。这种silver-bullet能够在身体内移动,直到找到肿瘤;当它们发挥功效时,bullet会打开,利用化学物质攻击肿瘤。这种方法...
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美发现自闭症新生物标志物
近期,南佛罗里达大学精神病学系和Silver儿童发展中心的研究小组在《美国实验生物学学会联合会杂志》上发表研究报告\AberrantT-lymphocytedevelopmentandfunctioninmiceoverexpressinghumansolubleamyloidprecursorprotein-α:implicationsforautism\称:与泛自...
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科学家用基因工程与实验动物追溯人类进化
...不过,通过该努力,Wray和杜克大学发育神经生物学家DebraSilver,观察了人类调控元件HARE5是如何改变小鼠的。研究显示,携带人类HARE5的小鼠胚胎形成的大脑大了12%。“HARE5可以很容易地成为人类大脑如何扩展的重要部分。”俄亥...
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氧疗与手术切口感染
...岱明.现代感染病学.上海:上海医科大学出版社,1998,36-55.4SilverⅠ.TissuePO2changesinacuteinflammation.AdvExpMedBiol,1978,94:769-774.5KlebanoffS.Oxygenmetabolismandthetoxicpropertiesofphagocytes.AmInternMed,1980,93:480-489.6HuntT,LinseyM,GrislisG,etal.Theeffectofdifferingambiento...
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EndogenousIRBPcanbedispensableforgenerationofnaturalCD4+CD25+regulatoryTcellsthatprotectfromIRBP-inducedretinalautoimmunity
...athol.65:152–160.Avichezer,D.,R.S.Grajewski,C.C.Chan,M.J.Mattapallil,P.B.Silver,J.A.Raber,G.I.Liou,B.Wiggert,G.M.Lewis,L.A.Donoso,andR.R.Caspi.2003.Animmunologicallyprivilegedretinalantigenelicitstolerance:majorroleforcentralselectionmechanisms.J.Exp.Med.198:1665–1676.Liou,G.I.,Y.Fei,N.S.Peachey...
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Roleof2-integrinsforhomingandneovascularizationcapacityofendothelialprogenitorcells
...isandarteriogenesis.Nat.Med.6:389–395.Asahara,T.,T.Murohara,A.Sullivan,M.Silver,R.vanderZee,T.Li,B.Witzenbichler,G.Schatteman,andJ.M.Isner.1997.Isolationofputativeprogenitorendothelialcellsforangiogenesis.Science.275:964–967.Shi,Q.,S.Rafii,M.H.Wu,E.S.Wijelath,C.Yu,A.Ishida,Y.Fujita,S.Kothari,R.M...
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Functionaldisruptionof4integrinmobilizesbonemarrow–derivedendothelialprogenitorsandaugmentsischemicneovascularization
...ciationgrant(0430135NtoG.Qin).ReferencesAsahara,T.,T.Murohara,A.Sullivan,M.Silver,R.vanderZee,T.Li,B.Witzenbichler,G.Schatteman,andJ.M.Isner.1997.Isolationofputativeprogenitorendothelialcellsforangiogenesis.Science.275:964–967.Rafii,S.,andD.Lyden.2003.Therapeuticstemandprogenitorcelltransplantatio...
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NatureCommunications:缺血坏死心肌交感神经支配或能重建
...igmapeptide,ISP),一直被CaseWesternReserveUniversity神经科学的Silver教授用于脊髓修复的研究。他与同事从事心脏病研究的Habecker教授交流时发现心肌“疤痕”与脊髓损伤有共同之处-脊髓损伤和有神经损伤的心肌都存在一种蛋白多糖的...
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低氧血症和高血糖症对正常猫视网膜pH的影响
...thalmol.2005Dec;123(12):1684-90.41美国埃文斯通西北大学的Padnick-SilverL博士及其同事研究了急性低氧血症和高血糖症对视网膜pH的影响以了解高血糖症在正常完整猫视网膜中诱导的变化。研究人员在血氧正常(动脉血氧分压[PaO2]=114.5±7.9m...
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输卵管妊娠治疗后的生殖状态
...娠率分别为49.3%和53.0%;再次异位妊娠率为9.9%和14.8%。在Silver等[12]的一项前瞻性研究中,输卵管切除与保留术后的宫内妊娠率分别为53.8%和60.0%;再次异位妊娠率为7.7%和18.3%。结果表明,保守术后的宫内妊娠率至少不低于输卵...
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研究发现负责在细胞中储存脂肪的基因
...。在最新的研究中,美国艾伯特·爱因斯坦医学院的DavidSilver和同事发现了两个将脂肪打包成脂滴的关键基因,分别为FIT1和FIT2。这两个基因彼此有50%的相似之处,它们编码的蛋白质长度超过200个氨基酸,且这种蛋白不与任何其它...
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老年人母外翻畸形围手术期处理
...cBride手术+第Ⅰ跖骨基底截骨+第Ⅱ趾趾间关节成形术1足,Silver手术2足,Austin手术1足(图1)。图1主要手术方式图1a.Keller手术;图1b.Keeller手术+Ⅰ跖骨基底截骨;图1c.Keller手术+Ⅰ跖骨基底截骨+Ⅱ趾跖趾和趾间关节成形术;图1d.McBr...
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HistonedeacetylaseactivityisessentialfortheexpressionofHoxA9andforendothelialcommitmentofprogenitorcells
....Blood.102:2555–2561.Asahara,T.,H.Masuda,T.Takahashi,C.Kalka,C.Pastore,M.Silver,M.Kearne,M.Magner,andJ.M.Isner.1999.Bonemarroworiginofendothelialprogenitorcellsresponsibleforpostnatalvasculogenesisinphysiologicalandpathologicalneovascularization.Circ.Res.85:221–228.Kalka,C.,H.Masuda,T.Takahashi,...
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RetinalchangesinjuvenileXlinkedretinoschisisusingthreedimensionalopticalcoherencetomography
...kedrecessiveretinaldisorder,thecharacteristicfunduscopicfindingsofwhichareasilver-greyretinalreflex,fovealretinoschisis,andperipheralretinoschisis.Electroretinograms(ERGs)typicallyrecordareducedb-waveamplitudewithrelativepreservationofthea-waveamplitude.Visualacuity(VA)usuallydeterioratesslowlyuntil...
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银杏叶提取物无助于预防痴呆请勿随意服用
...ancementARandomizedControlledTrialPaulR.Solomon,PhD;FelicityAdams,BA;AmandaSilver,BA;JillZimmer,BA;RichardDeVeaux,PhDJAMA.2002;288:835-840.ContextSeveralover-the-countertreatmentsaremarketedashavingtheabilitytoimprovememory,attention,andrelatedcognitivefunctionsinaslittleas4weeks.Theseclaims,however...
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阿希米治疗细菌性阴道病40例临床分析
...用妇产科杂志,1998,14(2):88. [3]DEMLINGRH,DESANTIL.Effectsofsilveronwoundmanagement[J].Wounds,2001,13(1SupplA):115. [4]NEDAM,TERAIY.Silver——Newmagicinmedicine[J].ScienceDigest,1978,5(5):193. [5]DIBROVP,DZIOBAJ,GOSINKKK,etal.Chemiosmoticmechanismofantimicro...
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脑出血中西医结合治疗新进展
...导耐受、抑制补体活化等正在进一步研究之中。3讨论3.1Silver[21]等在加拿大《医学邮报》中说:“多学科合作是现代卒中治疗的标志”。随着影像、外科、内科学及祖国医学的现代化发展,综合治疗是当今脑出血治疗的基本有...
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EvaluationofaNewSelectiveEnrichmentBrothforDetectionofGroupBStreptococciinPregnantWomen
...tionofStreptococcusagalactiaeinpregnantwomen.J.Clin.Microbiol.40:4329-4331.Silver,H.M.,andJ.Struminsky.1996.AcomparisonoftheyieldofpositiveantenatalgroupBstreptococcuscultureswithdirectinoculationinselectivegrowthmediumversusprimaryinoculationintransportmediumfollowedbydelayedinoculationinselectiveg...
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AnewcardiacMASTerswitchfortherenin-angiotensinsystem
...tensinsystem:conceptual,oraregulatorofcardiacfunction?Circ.Res.85::643-650.Silver,R.B.etal.2004..Mastcells:auniquesourceofrenin.Proc.Natl.Acad.Sci.U.S.A.101::13607-13612.Mackins,C.J.etal.2006..Cardiacmastcell–derivedreninpromoteslocalangiotensinformation,norepinephrinerelease,andarrhythmiasinische...
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ChromograninA:asurprisinglinkbetweengranulebiogenesisandhypertension
...ispositiontohypertension.ReferencesBlaschko,H.,Comline,R.S.,Schneider,F.H.,Silver,M.,andSmith,A.D.1967..Secretionofachromaffingranuleprotein,chromogranin,fromtheadrenalglandaftersplanchnicstimulation.Nature.215::58-59.Kim,T.,Tao-Cheng,J.-H.,Eiden,L.E.,andLoh,Y.P.2001..ChromograninA,an“on/off“swi...
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TheimmuneparadoxofsarcoidosisandregulatoryTcells
...granulomatousreactions.J.Immunol.161:6413–6420.Forman,J.D.,J.T.Klein,R.F.Silver,M.C.Liu,B.M.Greenlee,andD.R.Moller.1994.SelectiveactivationandaccumulationofoligoclonalV-specificTcellsinactivepulmonarysarcoidosis.J.Clin.Invest.94:1533–1542.Grunewald,J.,C.H.Janson,A.Eklund,M.Ohrn,O.Olerup,U.Persso...
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SpecimenStorageinTransportMediumandDetectionofGroupBStreptococcibyCulture
...ococcaldisease.RevisedguidelinesfromCDC.Morb.Mortal.Wkly.Rep.51(RR11):1-22.Silver,H.M.,andJ.Strumminsky.1996.AcomparisonoftheyieldofpositiveantenatalgroupBStreptococcuscultureswithdirectinoculationinselectivegrowthmediumversusprimaryinoculationintransportmediumfollowedbydelayedinoculationinselective...
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ApproachestoBacterialRNAIsolationandPurificationforMicroarrayAnalysisofEscherichiacoliK1InteractionwithHumanBrainMicrovascularEndothelialC
...onalandcomparativegenomicsofpathogenicbacteria.Curr.Opin.Microbiol.5:20-26.Silver,R.P.,W.Aaronson,A.Sutton,andR.Schneerson.1980.ComparativeanalysisofplasmidsandsomemetaboliccharacteristicsofEscherichiacoliK1fromdiseasedandhealthyindividuals.Infect.Immun.29:200-206.Stins,M.F.,P.V.Nemani,C.Wass,andK.S...
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DodevelopingBcellsneedantigen
...6:2005–2010.Hayakawa,K.,M.Asano,S.A.Shinton,M.Gui,D.Allman,C.L.Stewart,J.Silver,andR.R.Hardy.1999.PositiveselectionofnaturalautoreactiveBcells.Science.285:113–116.Lopez-Carvalho,T.,andJ.F.Kearney.2004.DevelopmentandselectionofmarginalzoneBcells.Immunol.Rev.197:192–205.Lucas,A.H.,andD.C.Reason....