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PNAS：抑制炎症阻断心肌纤维化
...国家科学院院刊PNAS杂志上。 可溶性环氧化物水解酶sEH，是组织修复相关免疫应答中的关键成员，不过在心脏病发作后，这种酶往往会产生事与愿违的影响。Chiamvimonvat解释道，sEH使促炎症的脂类介质增多，从而引起高水平的...
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早产儿和低体重儿的颅内出血CT检查与预后分析
...网膜下腔出血（SAH）37例（70.6%），脑室周围-脑室出血（SEH/IVH）11例（20.8%），其中8例为胎龄32周者，脑实质出血（IPH）4例（7.5%），小脑出血（ICEH）1例（1.1%）。53例中死亡11例（21%）。随访42例，其中SAH占32例，SEH/IVH占8例，IPH...
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Vascularlocalizationofsolubleepoxidehydrolaseinthehumankidney
...ethepharmacologicalactionofhormonesinthekidney(23).Solubleepoxidehydrolase(sEH)convertsEETsintotheircorrespondingdihydroxyeicosatrienoicacids(DHETs).Ingeneral,theDHETsarethoughttohavereducedbiologicalfunctionrelativetotheEETs,andhydrationoftheEETsbysEHrepresentsonemechanismwherebytheiractivitycanbea...
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肩负心血管疾病转化医学研究重大使命
...等血管病变的保护因子。“由于可溶性环氧化物水解酶（sEH）可降解内源性的EET，所以抑制sEH的作用有望成为一种通过增强EET介导的血管舒张作用来治疗心血管系统疾病的新型治疗方案。”朱毅说。 然而，问题的核心在于sEH...
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SurveyofGenesEncodingStaphylococcalEnterotoxins,ToxicShockSyndromeToxin1,andExfoliativeToxinsinMembersoftheStaphylococcussciuriGroup
...itedKingdomABSTRACTGenesencodingstaphylococcalenterotoxins(seatosee,seg,andseh),toxicshocksyndrometoxin1(tst),andexfoliativetoxins(etaandetb)werenotdetectedinalargepanelof48Staphylococcussciurigroupisolatestested.Thisstronglysuggeststhatproductionofthestaphylococcalexotoxinsbythesebacteriaishighlyun...
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PCR和RPLA法检测金黄色葡萄球菌肠毒素型别比较
... ［3］KatsuhikoOmoe,MachikoIshikawa,YuShimoda,etal.Detectionofseg,seh,andseigenesinStaphylococcusaureusIsolatesandDeterminationoftheEnterotoxinProductivitiesofS.aureusIsolatesHarboringseg,seh,orseiGenes［J］.JClinMicrobiol,2002,40(3):857～862. ［4］KrystynaKuzma,EdwardMalinowski,Hen...
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探索心中的奥秘：卫生部心血管分子生物学与调节肽重点实验室
...行了研究，最终发现能降解EET的可溶性表氧化物水解酶（sEH）是血管紧张素Ⅱ引起高血压和心肌肥厚的关键分子，因而sEH抑制剂有望成为新的高血压治疗药物。 点评：研究最深入、影响最深远的花生四烯酸的代谢产物包括前...
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Theassociationbetweenbetaineandcholineintakesandtheplasmaconcentrationsofhomocysteineinwomen
...m1FromtheDepartmentsofNutrition(SEC,ELG,LWD,WCW,andEBR)andEpidemiology(ELG,SEH,WCW,andEBR),HarvardSchoolofPublicHealth,Boston,MA;theDepartmentofNutrition,SchoolofPublicHealthandSchoolofMedicine,UniversityofNorthCarolinaatChapelHill,ChapelHill,NC(SHZ);andtheChanningLaboratory,DepartmentofMedicine,Bri...
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PNAS：可显著降低糖尿病症状的药物
...在这项研究中，一种酶——称为可溶性环氧化物水解酶（sEH）的抑制剂，不仅能预防糖尿病的发作，还能逆转糖尿病在肥胖小鼠中的影响。Hammock说：“我们以前的研究表明，我们正在研究的这种药物本身能降低小鼠的糖尿病症...
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胰岛稳态蛋白或是1型糖尿病治疗新靶点
...低，胰高血糖素水平升高，胰岛素生成细胞的死亡增加。Seh-HoonOh博士说：“总而言之，IhoP可调节血糖稳态；IhoP缺失导致胰腺处于临界状态并启动1型糖尿病的发生。”Oh是WakeForestBaptist大学再生医学系的讲师。目前认为，1型糖尿...
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Fructose,glycemicload,andquantityandqualityofcarbohydrateinrelationtoplasmaC-peptideconcentrationsinUSwomen
...EricBRimm1FromtheDepartmentsofNutrition(TW,EG,TP,andEBR)andEpidemiology(EG,SEH,andEBR),HarvardSchoolofPublicHealth,Boston;theDepartmentofLaboratoryMedicine,Children‘sHospitalandHarvardMedicalSchool,Boston(TWandNR);andtheChanningLaboratory,DepartmentofMedicine,HarvardMedicalSchoolandBrighamandWomen...
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PNAS：科学家发现可显著降低糖尿病症状的药物
...在这项研究中，一种酶——称为可溶性环氧化物水解酶（sEH）的抑制剂，不仅能预防糖尿病的发作，还能逆转糖尿病在肥胖小鼠中的影响。Hammock说：“我们以前的研究表明，我们正在研究的这种药物本身能降低小鼠的糖尿病症...
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新疆维吾尔族与汉族新生儿缺氧缺血性脑病的CT对照分析
...4.85%），脑实质出血（IPH）6例（3.63%），室管膜下出血（SEH）3例（1.82%），其中混合性出血（图2）30例（18.18%）；140例汉族患儿中合并颅内出血64例（45.71%），其中蛛网膜下腔出血（SAH）50例（35.71%），脑室内出血（IVH）6例（4.29%...
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欧洲可持续化学技术平台SusChem简介
...生活方式的图像：1.高效节能之家（TheSmartEnergyHome，简称SEH）在这个家庭里水和能源可以循环利用，充分使用如太阳能等的天然能源，很少有废弃物等等。2.一体化生物精炼厂（TheIntegratedBiorefinery）这里指的一体化、零污染物排...
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BodyironstoresandtheirdeterminantsinhealthypostmenopausalUSwomen
...Medicine,BrighamandWomen’sHospitalandHarvardMedicalSchool,Boston(J-ML,SEH,MJS,WCW,andJM);theNationalCenterforMaternalandInfantHealthandInstituteofReproductiveandChildHealth,PekingUniversityHealthScienceCenter,Beijing(J-ML);theDepartmentsofNutrition(MJSandWCW)andEpidemiology(SEH,MJS,andWCW),Harv...
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PNAS：控制肿瘤生长和转移的新组合药物
...COX-2抑制剂（类似于西乐葆Celebrex）和一种环氧化物酶（sEH）抑制剂——控制血管生成的药物，可限制肿瘤生长和扩散的能力。相关研究结果发表在2014年7月14日的《PNAS》杂志。本文资深作者、UC戴维斯分校的特聘教授BruceHammock称...
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Dietaryintakeoftransfattyacidsandsystemicinflammationinwomen
...ofMedicine,BrighamandWomen’sHospitalandHarvardMedicalSchool,Boston(DM,SEH,WCW,andEBR);theDepartmentsofNutrition(DM,TP,WCW,andEBR)andEpidemiology(DM,SEH,KJ,WCW,andEBR),HarvardSchoolofPublicHealth,Boston;theVeteransAffairsPugetSoundHealthCareSystem,UniversityofWashington,Seattle(DM);theFranz-Volh...
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Alcoholintakeandmethylenetetrahydrofolatereductasepolymorphismmodifytherelationoffolateintaketoplasmahomocysteine
...eDepartmentsofNutrition(SEC,ELG,DJH,MJS,WCW,andEBR)andEpidemiology(ELG,DJH,SEH,MJS,WCW,andEBR),HarvardSchoolofPublicHealth,Boston,MA,andtheDivisionofPreventiveMedicine(SEC)andtheChanningLaboratory(ELG,DJH,SEH,MJS,WCW,andEBR),DepartmentofMedicine,BrighamandWomen‘sHospitalandHarvardMedicalSchool,Bos...
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Dietaryglycemicindexandcarbohydrateinrelationtoearlyage-relatedmaculardegeneration
...SAllcoauthorscontributedsubstantiallytothismanuscript.C-JC,LDH,PFJ,LTC,WCW,SEH,andATwereresponsibleforthedesignandconceptoftheproject.C-JC,GR,PFJ,andATparticipatedinthedataanalysisandwritingofthemanuscript.ATconceivedoftheproject,arrangedforthevariousinstitutestocollaborate,andobtainedfunding.WCW,SE...
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CytotoxinandPyrogenicToxinSuperantigenGeneProfilesofStaphylococcusaureusAssociatedwithSubclinicalMastitisinDairyCowsandRelationshipswithMa
...arriedbothislands.Onlyonecontainedseb(togetherwithSa-1),andanothercontainedseh(togetherwithlukED).Theisolateswerealsoanalyzedbypulsed-fieldgelelectrophoresisperformedwithSmaI.Thirty-nineSmaIprofiles(similaritycoefficient[S]=0.94to0.21)weredifferentiated;12,1,and10ofthese,respectively,weregeneratedby...
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ComparisonbetweenplasmaanderythrocytefattyacidcontentasbiomarkersoffattyacidintakeinUSwomen
...nandFrankBHu1FromtheDepartmentsofNutrition(QS,HC,andFBH)andEpidemiology(QS,SEH,andFBH),HarvardSchoolofPublicHealth,Boston,MA,andtheChanningLaboratory,DepartmentofMedicine,BrighamandWomen‘sHospitalandHarvardMedicalSchool,Boston,MA(JM,SEH,andFBH)2SupportedbyresearchgrantsCA49449,CA42182,HL24074,HL34...
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急性自发性颈椎管硬膜外血肿的诊治体会
...分恢复2例，无恢复1例。 3讨论 脊髓硬膜外血肿(SEH)是临床上一种少见的急症，无明显年龄、性别差异[1]。其病因可能为：硬膜外血管畸形破裂、血液病、抗凝治疗后、高血压等[2]，但多数无明显病因可寻。有学者根据出...
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Dietaryfatintakeandearlyage-relatedlensopacities
...earchCenteronAgingatTuftsUniversity,Boston,MA;theDepartmentsofEpidemiology(SEHandWCW)andNutrition(WCW),HarvardSchoolofPublicHealth,Boston,MA;andtheChanningLaboratory,DepartmentofMedicine(SEHandWCW)andtheCenterforOphthalmicResearch,DepartmentofOphthalmology(LTC),HarvardMedicalSchoolandBrighamandWomen...
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高强度聚焦超声治疗胰腺癌的胃肠道准备
...withHIFUfor262person-times.Beforetreating,thesepatientshavefirsttakenaChineseherbalactingasstrengtheningthebodyresistancetoeliminatepathogenicfactors,relivingthedepressedliver,sootingtheliverandregulatingthecirculationofqi（气）,promotingdigestionanddigestantfor3～4days.In262person-times,74perso...
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缺血缺氧性脑病
...见，易破入临近的侧脑室而成为室管膜下-脑室内出血（SEH-IVH）。【发病机理】尚未完全明了，有待深入研究。1.脑血流量调节功能降低正常新生儿脑血管以舒张和收缩来调节进入脑组织的血流量，当血流量减少时脑血管舒张，...
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StaphylococcusaureusExpressUniqueSuperantigensDependingontheTissueSource
...F,ACGTCTCCACCTGTTGAAGG;SEG-R,TGAGCCAGTGTCTTGCTTTG(400-bpfragmentamplified);SEH-F,TTTCATTCACATCATATGCG;SEH-R,AAATCATTGCCACTATCACC(184-bpfragmentamplified);SEI-F,TTGATACTGGAACAGGACAAGC;SEI-R,ACACCAATATCACCTTGAGC(239-bpfragmentamplified);SEJ-F,CTTTAGTTTACAGCGATAGC;andSEJ-R,TTATCTTTTCAGAGATACCC(138-bpfr...
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穿透性角膜移植术中脉络膜上腔出血的手术配合
...4讨论暴发性脉络膜上腔出血（suprachoroidadexpulsivehemrrhage,SEH）是眼科手术少见的最严重的并发症。其发生原因与眼部血管条件、术中持续低眼压、切口开放时间过长有直接关系。在本病例中，其发生原因可能与炎症所致血管变性...
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EpoxyeicosatrienoicAcidsRegulateTrpChannel–DependentCa2+SignalingandHyperpolarizationinEndothelialCells
...ellsispotentiatedbycytochromeP450(CYP)expressionandsolubleepoxidehydrolase(sEH)inhibition.Anepoxyeicosatrienoicacid-inducedtranslocationofaTrpC6-V5fusionproteintotheendothelialcellmembraneviaacAMP-dependentmechanismcanaccountforthesefindings.【关键词】caveolaecytochromePendotheliumderivedhyperp...
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CT检查对新生儿缺血缺氧性脑病的诊断价值
...（SAH）者51例，脑室内出血（IVH）者4例，室管膜下出血（SEH）者1例，硬膜下出血（SDH）者1例。本组中度异常61例，并SAH者30例，IVH者12例，SHE者2例，脑实质出血（ICH）者2例，SDH者2例。本组重度异常的19例病儿均有颅内出血，其...
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Epoxidehydrolaseandepoxygenasemetabolitesastherapeutictargetsforrenaldiseases
...2,78,79,94).Recentinteresthasalsofocusedontheroleofsolubleepoxidehydrolase(SEH)inrenalandcardiovasculardiseaseandinhibitionofthisenzymeasanavenuetoincreaseEETlevels.ThisreviewwillhighlightthesefavorableEETpropertiesthatcouldprotectthekidneyfromESRDduringrenalandcardiovasculardiseasestates.EPOXYGENAS...