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腹膜后纤维化引起的尿路梗阻
腹膜后纤维化(retroperitonealfibrosis,RPF)系腹膜后结缔组织广泛纤维化,压迫血管、神经、胃肠道和输尿管出现临床症状,其中输尿管周围发生纤维化粘连,压迫上尿路引起肾积水和肾功能衰竭最为常见。我院1986年以来共收治腹膜后...
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结核杆菌复苏因子体外刺激结核病人血淋巴细胞增殖的试验研究
...苏的蛋白质,研究表明[1]结核分枝杆菌复苏因子蛋白质(Rpf)亚单位疫苗在小鼠试验中有很高的免疫反应,除RpfC外,均能诱导产生抗体IgG1和IgG2α、γ-IFN、IL-10、IL-12,促进T细胞增殖。因此,我们应用Rpf刺激结核病人血淋巴...
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妊高征患者肾功能检测及临床意义
...统变化较大,肾脏略增大,肾血浆流量(renalplas-maflow,RPF)及肾小球滤过率(glomerularfiltrationrate,GFR)于妊娠早期均增加,整个妊娠期间维持高水平,RPF比非孕时约增加35%,GFR约增加50%。代谢产物Urea、Cr、UA等排泄增多,血中浓...
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梗阻性肾病
...快慢而定。急性慢性GFR下降,近端肾小管压力可以正常,RPF改变可以不十分明显,加上对侧RPF可能可以代偿性上升,其机制可能是肾-明反射被激活所致。慢性发生的单侧输尿管梗阻一般输尿管内压力不如急性者为高,近端肾小...
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RenalfunctionmeasurementsfromMRrenographyandasimplifiedmulticompartmentalmodel
...sproposedformeasurementofsixfunctionalparametersthatincluderenalplasmaflow(RPF)andGFR.CompleteModel:SevenCompartmentsThefullmulticompartmentalmodel(Fig.1)dividesthevascular-nephronunitintosevencompartments:theintrarenalarteriesandglomerularvessels(A),vasarectaandveins(V),proximalconvolutedtubule(P),...
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体外循环的抗凝与拮抗
...输血:2.应用鱼精蛋白代用品如重组的血小板因子4(rPF4)和抗肝素灵,PF4储存与血小板2颗粒中,是天然的肝素结合蛋白。rPF4与鱼精蛋白之比>3:1才使ACT延长,抗肝素灵>5:1使ACT延长。但目前临床尚未使用。...
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梗阻性肾病
...快慢而定。急性慢性GFR下降,近端肾小管压力可以正常,RPF改变可以不十分明显,加上对侧RPF可能可以代偿性上升,其机制可能是肾-明反射被激活所致。慢性发生的单侧输尿管梗阻一般输尿管内压力不如急性者为高,近端肾小...
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Exogenous5‘-nucleotidaseimprovesglomerularautoregulationinThy-1nephriticrats
...redetermined.Inthefirstseriesofexperiments,autoregulationofrenalplasmaflow(RPF)orglomerularfiltrationrate(GFR)wasimpairedinnephriticrats.Inresponsetoareductioninbloodpressure(98±2to80±1mmHg),bothRPF(4.17±0.63to3.20±0.45ml·min-1·gkidneywt-1,P0.05,n=6)andGFR(0...
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肥胖人的肾脏疾病有何特点?
...动物实验发现,其单位时间内尿排泄量减少,肾血流量(RPF)、肾小球滤过值(GFR)均减少;肥胖引起的肾脏损害的形态学改变是肾脏脂肪含量的增加,重量增加,体积增大;组织学的检查发现,肾小管、肾小球的基底膜常有明显的...
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凝血、抗凝与拮抗
...血和输血;2)应用鱼精蛋白代用品如重组的血小板因子4(rPF4),PF4储存于血小板a颗粒中,是天然肝素结合蛋白,rPF4与肝素之比>3:1才使ACT延长。抗肝素灵在>5:1才使ACT延长。但目前临床尚未使用。 (七)鱼精蛋白过敏反应...
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LS9公司商业规模验证生产可再生柴油
...业规模验证生产可再生柴油。新的“可再生石油工厂”(RPF)于2010年生产5万~10万加仑超清洁柴油(UltraCleanDiesel),这一生产规模将确认该公司超清洁柴油(UltraCleanDiesel)技术的可行性。一旦验证规模试验完成,LS9公司将快速将该...
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ModelingGFRtrajectoriesindiabeticnephropathy
...riaormacroalbuminuria(17)envisagedphysiologicalstudies[GFR,renalplasmaflow(RPF),etc.]occurringevery6mo.Thisfrequencyofsamplingwasaccomplishedinaboutone-halfofthepatientsforthefirst4yr.Intheremainingone-halfofthesubjects,thefirstfollow-upstudywas1yrafterthebaselinestudies,withthestudyfrequencyincreas...
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Adaptivehyperfiltrationintheagingkidneyaftercontralateralnephrectomy
...ologicalevaluation.AllsubjectsunderwentadeterminationofGFR,renalplasmaflow(RPF),andpreglomerularvascularpressures,accordingtoaprotocolapprovedbytheInstitutionalReviewBoardofStanfordUniversitySchoolofMedicine.Initially,bloodwassampledfordeterminationofplasmaoncoticpressure().Urinewasvoidedspontaneous...
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Hepatocytegrowthfactorinducesanendothelin-mediateddeclineinglomerularfiltrationrate
...ontentweredeterminedbyliquidscintillationcounting,andGFRandrenalplasmaflow(RPF)werecalculatedbythestandardformulas(23).Sixgroupswerestudied(seeTable1).Ratsreceivedeithernopretreatment,theETA/ETBreceptorblockerbosentan(200mg/kg)bygavage1hbeforethestudy,ortheANGIIreceptorantagonistcandesartan(5mg/kg),...
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对慢性肾功能衰竭实验动物模型的改进
...后尿白蛋白显著增加,菊粉廓清率(Cin)、肾血浆流量(RPF)减少。如并用肾切除法,单个肾单位的蛋白量明显增加,收缩压(SBP)升高,Cin降低,肾小球明显肥大,有初期的肾小球硬化。长期的实验,肾小球硬化更严重,局灶...
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黄芪注射液并用贝那普利治疗早期糖尿病肾病的疗效观察
...尿微量白蛋白的排出,使糖尿病大鼠升高的肾血浆流量(RPF)、肾小球滤过率(GFR)明显降低,并使肾皮质、髓质内升高的一氧化氮合成酶(iNOS)基因表达明显下调,从而部分纠正DN早期的肾脏高滤过、高灌注。另据报道,黄芪...
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Thedynamicsofglomerularfiltrationinthepuerperium
...armicrocirculation(30,47,49,50).Thesecondisanelevatedrateofrenalplasmaflow(RPF)(3,14,18,52).Anensuinghyperperfusionofglomerulibluntstheextenttowhichtheaxialproteinconcentrationandoncoticpressurecanincreasealongtheglomerularcapillariesduringfiltrateformation(11).Incontrasttothegravidstate,thereisscan...
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黄芪和卡托普利联合治疗糖尿病早期肾病的疗效观察
...芪在不影响糖尿病血糖、血压的情况下,可使早期升高的RPF、GFR部分下降[6],从而降低尿蛋白的排出。卡托普利为ACE抑制剂,可控制血压,阻滞肾内血管紧张素2的生成,相对优势地扩张肾小球出球小动脉,降低肾小球囊内压...
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RenalHemodynamicInflammatoryandApoptoticResponsestoLipopolysaccharideinHO-C/CMice
...ance(RVR)wasdeterminedastheratioofmeanarterialpressure:RBF.Renalplasmaflow(RPF)wascalculatedbyRBFx(100Chematocrit)/100.FiltrationfractionwascalculatedasGFR/RPF.mRNAExpressionbyQuantitativeReal-TimeReverseTranscriptase-PolymeraseChainReaction(RT-PCR)Foranalysisofgeneexpression,totalRNAwasextractedfro...
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第八章 尿的生成和排出--第一节 肾的功能解剖和肾血流量
...皮质的血流量。图8-5肾血流量和肾小球滤过率的自身调节RPF:肾血浆流量GFR:肾小球滤过率 关于自身调节的机制,有人提出肌源学说来解释。此学说认为,当肾灌注压增高时,血管平滑肌因灌注压增加而受到牵张刺激,这使...
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黄芪注射液并用贝那普利治疗早期糖尿病肾病的临床疗效
...尿微量白蛋白的排出,使糖尿病大鼠升高的肾血浆流量(RPF)、肾小球滤过率(GFR)明显降低,并使肾皮质、髓质内升高的一氧化氮合成酶(iNOS)基因表达明显下调,从而部分纠正DN早期的肾脏高滤过、高灌注。另据报道[6]...
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InhibitionofRas/ERK1/2signalingprotectsagainstpostischemicrenalinjury
...ofinulin[arterial-venous/arterialconcentration(A-V/A)x100];renalplasmaflow(RPF)wascalculatedbytheratioglomerularfiltrationrate(GFR)/filtrationfraction(FF),andrenalbloodflowbycorrectionofRPFbyhematocrit[RBF=RPF/(1-Hct)/100];renalvascularresistances(RVR)wereestimatedbytheexpressionRVR=MAP/RBF,whereMAP...
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不同亚型注意缺陷多动障碍儿童威斯康星卡片分类测验研究
...lgroup,theADHDgroupshowedsignificantlylessinthescoresofresponseserrors(Re),Rpf,perseverativeresponses(Rp),perseverativeerrors(Rpe)andnonperseverativeerrors(nRpe).ThechildrenwithADHDindifferentsubtypesshowedsignificantlylessscoresthanthecontrolgroupinthescoresofReandRfp.Inaddition,thePItypeshoweds...
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Cyclooxygenase-2inhibitionnormalizesarterialbloodpressureinCYP1A1-REN2transgenicratswithinducibleANGII-dependentmalignanthypertension
...8±6vs.136±4mmHg,P0.01).Therewasnodifferenceinrenalplasmaflow(RPF)orglomerularfiltrationrate(GFR)betweeninducedandnoninducedrats.NimesulideelicitedalargerdecreaseinMAPinhypertensiverats(188±6to140±8mmHg,P0.01)thaninnormotensiverats(136±4to113±8mmHg,P0.01).Add...
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Shunt-AssociatedMigraineRespondsFavorablytoAtrialSeptalRepair
...chisreportedinTable1.Thecompositetotalscorethusobtainedrangesfrom0to10.AfterPFOclosureinSSorSAandthebaselinevisitinCTRLS,allpatientsweregivenadiaryinwhichtheyhadtomarkthecharacteristicsofeachsubsequentmigraineattackintermsofseverity,duration,andpresenceofauraaswellasthemedicationusedandtheefficacyof...
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中医药治疗早期糖尿病肾病进展
...素方法分别测定用药前后肾小球滤过率(GFR)和肾血浆流量(RPF)以及ALB/Cr、RBP/CR、24h尿蛋白定量等。结果:大黄组治疗后GFR下降,尿ALB/Cr、24h尿蛋白定量均减少,与治疗前及对照组治疗后比较均有显著性差异(P0.05)。实验研究...
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中晚期子宫颈癌低氧放疗并化疗的临床效果
...显示,低氧照射对骨髓及外周淋巴细胞的放射防护因子(RPF)分别为1.48和1.39。说明低氧放疗对小鼠骨髓有核细胞及外周淋巴细胞具有一定的保护作用,这为临床上特别是腹盆部大野照射采用低氧放疗提供了实验依据和参数[4]...
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Overexpressionofkidneyneutralendopeptidase(EC3.4.24.11)andrenalfunctioninexperimentalcirrhosis
...dot;h-1PAHfor150mintoassessglomerularfiltrationrate(GFR)andrenalplasmaflow(RPF)atdifferenttimesbymeansoftheirrespectivesteady-stateplasmaclearances(CInandCPAH)(10,30).After90minofinulinplusPAHinfusion(i.e.,oncetheirsteady-stateplasmaconcentrationswerereached)(10),alaparotomywasperformedandtheurinary...
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Short-termnitricoxideinhibitioninducesprogressivenephropathyafterregressionofinitialrenalinjury
...ichmeanarterialpressure(MAP),glomerularfiltrationrate(GFR),renalplasmaflow(RPF),andrenalvascularresistance(RVR)weremeasured.Glomerularhydraulicpressure(PGC)wasdirectlydeterminedbymicropunctureofsuperficialglomeruli.Thedetailsoftheexperimentalproceduresandanalyticaltechniquesutilizedinthesestudiesare...
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Testosteronesupplementationinagingmenandwomen:possibleimpactoncardiovascular-renaldisease
...ewasasimilarincreaseinbloodpressureandreductionineffectiverenalplasmaflow(ERPF)inmenandwomen,butGFRwasmaintainedinmenonly,leadingtoanincreaseinthefiltrationfraction(FF),whichsuggestsanincreaseinglomerularcapillarypressure(48).Inwomen,thereductioninERPFwasassociatedwithaconcomitantreductioninGFR,resu...