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单个蛋白表达可触发大规模免疫活动
...。AdrianHayday和合作者培育了一种小鼠，其压力应答蛋白质Rae1可根据需要开关。Rae1的引入促发了皮肤上免疫细胞的重组，以及来自血液的受激免疫细胞的渗透。他们吃惊地发现，当其他地方的免疫细胞处于抑制状态时，皮肤上的...
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Adenovirusserotype5E1AsensitizestumorcellstoNKG2D-dependentNKcelllysisandtumorrejection
...A-p300,up-regulatedtheexpressionoftheNKG2Dligandretinoicacidearlyinducible(RAE)-1,butnotmurineULBP-liketranscript1,anotherNKG2Dligand,infourindependentlyderivedMCA-205transfectants.Theup-regulationofRAE-1byE1AtargetedMCA-205tumorcellstolysisbyNKcells,resultinginNKG2D-dependenttumorrejectioninvivo.Mo...
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NKG2Dfunctionprotectsthehostfromtumorinitiation
...entonsarcomasemerginginWTmice,sarcomasderivedfromperforin-deficientmicewereRae-1+andimmunogenicwhentransferredintoWTsyngeneicmice.ThesefindingssuggestanimportantearlyrolefortheNKG2Dincontrollingandshapingtumorformation.NKG2DisakeyhomodimericactivationreceptorexpressedonthecellsurfaceofalmostallNKcel...
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DailyconsumptionofIndianspinach(Basellaalba)orsweetpotatoeshasapositiveeffectontotal-bodyvitaminAstoresinBangladeshimen
...otene[12µgß-carotene=1µgretinol=1retinolacitivityequivalent(RAE)]andfrom12:1to24:1for-carotene,-carotene,andß-cryptoxanthin(24µgotherprovitaminAcarotenoids=1µgretinol=1RAE).Theequivalencyfactorswereincreasedbecauserecentevidenceindicatesthattheefficiencyofabsorptionof&#...
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NKcellactivationthroughtheNKG2DligandMULT-1isselectivelypreventedbytheglycoproteinencodedbymousecytomegalovirusgenem145
...fection;MULT,murineUL16-bindingprotein-liketranscript;ORF,openreadingframe;RAE,retinoicacidearlyinducible.H.Hengel‘spresentaddressisInstituteforVirology,HeinrichHeineUniversityDuesseldorf,40225Duesseldorf,Germany.Theonlineversionofthisarticlecontainssupplementalmaterial.MouseCMV(MCMV)sharesmanyfea...
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Useofashort-termisotope-dilutionmethodfordeterminingthevitaminAstatusofchildren
...9,14,20,20,20-[2H8]retinylacetate[D8vitaminA;2116retinolactivityequivalent(RAE)].Anotherclassroomgroup(group2)comprised34subjects(20boysand14girls)whoprovidedbloodsamples3dand21dafterreceivinga.7.4-µmol(2.5-mg)doseofD8vitaminA(2116RAE).Fromthecorrelationbetweenthe6-hor3-ddataandthe21-ddata,weat...
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DietaryvitaminAintakesofFilipinoelderswithadequateorlowlivervitaminAconcentrationsasassessedbythedeuterated-retinol-dilutionmethod:implic
...minAinliverwere135±86and134±104µgretinolactivityequivalents(RAE)/d,respectively;intakesofthemenandwomenwithlowvitaminAinliverwere75±53and60±27µgRAE/d,respectively.Total-bodyvitaminAorlivervitaminAbutnotserumretinolcorrelatedwithdietaryRAE,preformedvitaminA,ß-carote...
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数字医学研究院与英国名校开展合作
...校作为期两天的访问。DeMontfort大学始建于1870年，是2001年RAE（英国科研质量评估机构）高执行现代大学之一。鉴于该校的快速成形与制造中心在数字医学模型制造方面作出了卓有成效的工作，本院与该中心就科研、应用、生产以...
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尊重科技创新规律完善绩效评价体系
...制定；英国高等教育基金委员会（HEFCs）根据科研评价（RAE）的结果对大学进行科研经费的分配。第六，通过立法提供制度保障。1993年，美国克林顿政府颁布了《政府绩效与结果法案》（GPRA），要求包括科学研究资助机构在内...
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肺动脉高压2004：诊断、治疗进展和未来发展方向
...yAutoantibodytestsHIVtestLFTsandclinicalevidenceofcirrhosisandportalhtnRVE,RAE,?RVSPLeftheartdiseaseVHDCHDEmphysemaFibrosisThoracicabnlSleepdisorderChronicThrombo-embolismSclerodermaSLERAVasculitisHIVPortopulmonaryHypertensionEvaluationofPAHFunctionalTestRHCathUnderlyingCellularMechanismsGeneticBMPR...
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Useofpopulation-weightedEstimatedAverageRequirementsasabasisforDailyValuesonfoodlabels
...ighestRDAforvitaminAforanysinglelife-stageandsexgroupinthetargetpopulation.RAE,retinolactivityequivalent.AsillustratedbythespreadofthesimulateddistributioninFigure2,considerablevariationinvitaminArequirementsexistswithinthepopulation.ThisvariationisafunctionofthefactthatEARsforvitaminArangefrom275&#...
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A4-YearStudyoftheEpidemiologyofVibriocholeraeinFourRuralAreasofBangladesh
...;revised6September2002;electronicallypublished13December2002.HowVibriocholeraespreadsaroundtheworldandwhatdeterminesitsseasonalpeaksinendemicareasarenotknown.Thesefeaturesofcholerahavebeenhypothesizedtobeprimarilytheresultofenvironmentalfactorsassociatedwithaquatichabitatsthatcannowbeidentified.Sinc...
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中科大田志刚最新《PNAS》文章
...可以诱导CD8肠上皮淋巴细胞中NKG2D表达。同时阻断NKG2D和Rae1之间的相互作用则会抑制上皮淋巴细胞的细胞毒素，从而减轻聚肌胞导致的上皮破坏，以及小肠的急性mucosalinjury。这些结果都证明TLR信号可以通过NKG2D途径引起组织损伤...
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ß-Carotene–richorange-fleshedsweetpotatoimprovesthevitaminAstatusofprimaryschoolchildrenassessedwiththemodified-relative-dose-respon
...#223;-carotene–richOFSP[Resistovariety;1031retinolactivityequivalents(RAE)/d]andtheother(n=90;controlgroup)anequalamountofboiledandmashedWFSP(Bosbokvariety;0RAE/d).AllthechildreninGrades1–3receivedone500mgmebendazolechewableanthelminthictablettoexcludehelminthicinfectionasaconfounder.Treat...
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ElevatedvitaminAintakeandserumretinolinpreadolescentchildrenwithcysticfibrosis1,2,
...orallchildrenwithCFandPI,specifically3000µgretinolactivityequivalents(RAEs)perdayforchildrenaged8.0y(13,14).CF-specificwater-solublepreparationsarewidelyused,includingvitaminsA,D,E,andK(AxcanPharma,Birmingham,AL;availableintheUSmarketsince1992);Vitamax(Shear/KershmanLabs,Chesterfield,MO;availab...
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1HowardHughesMedicalInstitute,UniversityofAlabamaatBirmingham,Birmingham,AL35294
...2-terminalkinase;MCMV,murinecytomegalovirus;PI3K,phosphoinositide-3-kinase;Rae-1,retinoidacidearlyinducibletranscript;SFK,src-familykinase.S.L.NuttandD.M.Tarlintoncontributedequallytothiswork.TheactivationofNKcellsformspartoftheinnateimmuneresponsetoparasites,tumors,andvirallyinfectedcellsandisimpor...
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急性病毒性脑炎所致精神障碍51例临床分析
...gnosisofservereheadinjury［J］.Neurology,1995,45(5);915-918. ［3］Rae-GrantAD,EckertN,BarbourPJ,etal.Outcomeofserverebraininjury:Amultimodalityneurophysiologicstudy［J］.JTrauma,1996,40(3):401-407. ［4］SirenJ,SeppalainenAM,LaaunesJ.IsEEGusefulinassessingpatientswithacuteencephalit...
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多菌型麻风联合化疗期满后麻风菌的活性及复发的研究
...联合化疗麻风菌活性复发 Studyonviabilityofmycobacteriumlepraeaftermultidrugtherapy inmultibacillaryleprosyandrelapse HuangJinmei，ZhengHeping，PanHuiqing，etal.GuangdongProvincialCentersforSkinDiseasesandSTDsControlandPrevention，Guangzhou510500【Abstract】ObjectiveToi...
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IdentificationandCharacterizationofGenomicVariationsbetweenMycobacteriumbovisandM.tuberculosisH37Rv
...51.ThefourgeneswereBLASTsearchedintheM.smegmatis,M.avium,M.marinum,andM.lepraegenomes(datanotshown).OrthologuesofrpfAgenesexistinallofthem.However,noRv3479andlppAorthologueswerefoundinthesemycobacteria.TheorthologuesofRv0648presentinM.smegmatis,M.avium,andM.marinumhaveasizesimilartothatofM.bovis,sug...
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BacteremiaCausedbyanUndescribedSpeciesofJanibacter
...thetypestrainsofJanibacterbrevis(GenBankaccessionno.AJ310085),Janibacterterrae(GenBankaccessionno.AF176948),andJanibacterlimosus(GenBankaccessionno.Y08539).Italsoshowed97%similaritytothesequenceofthetypestrainofJanibactermelonis(GenBankaccessionno.AY522568).Thesefive16SrRNAgenesequenceswerealignedwi...
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TheherpesviralFcreceptorfcr-1down-regulatestheNKG2DligandsMULT-1andH60
...),theminorhistocompatibilityantigenH60(6),andtheretinoicacidearlyinducible(RAE)-1isoforms(7).Bothhumancytomegalovirus(HCMV)andmousecytomegalovirus(MCMV)encodeproteinsthatnegativelyregulatethecellsurfaceexpressionofNKG2DligandsandthuscompromisetheefficacyofNKandTcellresponses(2).AmongthemembersoftheM...
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上胸椎手术途径探讨（附21例报告）
...椎;骨科手术方法Studyoftheoperativeapproachoftheupperthoracicvertebrae(reportof21cases)∥XIEShuosheng,HANZhixiong,HUANGDezheng,etal.DepartmentofOrthopedics,thePeople`sHospitalofYulin,Yulin,Guangxi537000,ChinaAbstract：［Objective］Toinvestigatetheanatomicalrelationbetweenmanubrium...
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InvolvementofStreptococcalMitogenicExotoxinZinStreptococcalToxicShockSyndrome
...showedsofttissueinflammatorychangesfromT12toL2butnoabnormalitiesinthevertebrae,spinalcord,ornerveroots.Testingofacute-andconvalescent-phaseserashowednoevidenceofrecentinfectionwithdenguevirus,Leptospiraspp.,Rickettsia,Legionellaspp.,RossRivervirus,orotherarboviruses.Onday12afterheradmission,shedevel...
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Useofthedeuterated-retinol-dilutiontechniquetomonitorthevitaminAstatusofNicaraguanschoolchildren1yafterinitiationoftheNicaraguannational
...ncentrationofvitaminAinsugarwas10–15µgretinolactivityequivalents(RAE)/g[1µgretinol=1RAE(4)].However,alargevariationinvitaminAconcentrationswasfoundinbatchesofthesugarsamplesanalyzed.Inonestudy,theanalysesofsugarsamplestakenfrom131–150householdsin5regionsinNicaragua,conducted5time...
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Health-RelatedQualityofLifeAmongYoungAdultsWithIschemicStrokeonLong-TermFollow-Up
...tomsrelatedtolateeffectsofpoliomyelitis.ActaNeurolScand.2000;101:153–158.Rae-GrantAD,EckertNJ,BartzS,ReedJF.Sensorysymptomsofmultiplesclerosis:ahiddenreservoirofmorbidity.MultScler.1999;5:179–183.StenagerE,KnudsenL,JensenK.Acuteandchronicpainsyndromesinmultiplesclerosis.ActaNeurolScand.1991;84:1...
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Variationassociatedwithmeasurementofretinalvesseldiametersatdifferentpointsinthepulsecycle
...quivalentorCRVE)andthearteriolardiameters(centralretinalarteryequivalentorCRAE)changeatdifferentpointsinthecardiaccycle.15AcrossthecardiaccycletheCRVEchangedby3.1%andtheCRAEchangedby4.3%.ThechangesfollowedasimilarcardiacpatterntothosefoundbyChenetal.However,Reshef’sstudywassmallandthesechangesdidn...
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SugarsInhibitExpressionoftheRugosePhenotypeofVibriocholerae
...teransAffairsMarylandHealthCareSystem,Baltimore,MarylandABSTRACTVibriocholeraecanshifttoarugosecolonyphenotype,reflectingexpressionofanexopolysaccharidethatprovidesprotectionagainstavarietyofenvironmentalstresses.Ourdataindicatethatexpressionoftherugosephenotypeisinhibitedbyavarietyofsugars,includin...
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HepaticCatabolismofRemnantLipoproteins:WheretheActionIs
...larstructuresthatremnantsencounteraftertheyenterthespaceofDisseviathefenestrae(100to200nmdiameter)ofendothelialcellsthatlinehepaticsinusoids.WisseetalhavepostulatedadynamicallyactivespaceofDisseundergoingforcedsievingoflipoproteinparticlesthroughaprocessofsinusoidal“endothelialmassage“bycompress...
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DietaryReferenceIntakes:developmentandusesforassessmentofmicronutrientstatusofwomen—aglobalperspective
...dequatestores.TheRDAforwomenis700µgofretinolactivityequivalentsperday(RAE/d).RAEconversionfactorsare1:12forß-carotene,1:24foralphacaroteneand1:24forbetacryptoxanthin.Theseconversionfactorsaremuchhigherthanthe1:6conversionratesthathadhistoricallybeenused.Thenewconversionfactorsmeanthatlarge...
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NovelApplicationoftheMasson-FontanaStainforDemonstratingMalasseziaSpeciesMelanin-LikePigmentProductionInVitroandinClinicalSpecimens
...o,thedemonstrationofdiphenoloxidaseactivityintheneurotropicMycobacteriumlepraefurthersupportedtheimportanceofthispathwayinhumanpathogensthatcanusemelaninasanimmunomodulator(15,17).TheproposedMasson-Fontanastainingforevaluationoftheproductionofmelanin-likepigmentbyMalasseziaspecieshaspotentialapplica...