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17-β雌二醇对卵巢去势大鼠海马区tau蛋白Alzheimer样磷酸化的影响
...化的影响。方法18只雌性成年SD大鼠随机分为卵巢去势组(OVX组)、卵巢去势+17-β雌二醇组(OVX+17-βE2组)和假手术组(Sham-OVX组)，OVX组和OVX+17-βE2组动物卵巢切除后10天起分别皮下注射生理盐水0.1ml/d、17-β雌二醇20μg/(kg·d)。Sham-OVX组动物...
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Gonadalsteroidregulationofrenalinjuryinrenalwraphypertension
...inRWdiseaseseverityinmale(M)andfemale(F),castrated(Cast),andovariectomized(OVX)ratsandafterdihydrotestosterone(DHT)and17-estradiol(E2)treatment.MalecastrationattenuatedtheseverityofRW-inducedglomerulosclerosis(GS)[GSindex(GSI):RW-M,2.1±0.2;RW-Cast,1.3±0.2;RW-Cast+DHT,2.4±0.4],meanglomerularvolume...
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不同剂量雌激素对去势大鼠血脂代谢的影响
...方法选用日龄120天雌性SD大鼠，随机分为2组：去卵巢组（OVX组）和假去卵巢组（Sham组），OVX组于术后60天再随机分为4组皮下注射不同剂量雌激素。于第10次注射雌激素后第2天全部动物均取血，离心分离血清，用酶法测定血脂，...
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染料木素和17β-雌二醇对去卵巢大鼠松质骨微结构的作用
...研究目的是观察染料木素和小剂量17β-雌二醇对去卵巢（OVX）大鼠松质骨微结构的作用。方法采用90只7月龄SD大鼠被随机分为基线组、OVX组、假手术（SHAM）组、小剂量17β-雌二醇干预组（10μg·kg^-1·d^-1，EST组）和染料木素干预组...
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铝致Alzheimer病对尿中微量元素排出的影响
...SD大鼠29只,随机分为卵巢假切组（sham组）、卵巢切除组（ovx组）、卵巢切除合并慢性铝中毒组（ovx+AL3+组）、卵巢切除合并慢性铝中毒及尼尔雌醇灌胃组(ovx++AL3++E2组)。收集24的尿液,采用日本岛津ICPQ-1012型电感耦合等离子体发射...
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实验性骨质疏松模型骨组织中核因子表达特征及其意义
...小鼠随机分假手术对照组(CON组)和去卵巢骨质疏松模型组(OVX组)，术后第12周测量全身骨密度后处死，取股骨下端用ABC免疫组织化学、原位杂交方法测定骨组织中核因子的蛋白含量及表达水平并进行细胞定位。结果OVX组与CON组相比...
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在去卵巢诱导骨质疏松的大鼠中，针灸对骨密度的治疗和预防作用
...中国天津的医生合作，对在去卵巢诱导骨质疏松的大鼠（OVX）中，针灸在它们骨密度的治疗和预防作用方面进行了研究，并对不同针灸部位在胫骨、股骨或脊椎上是否有不同的治疗效果进行了评价。研究选取了35只雌性SD大鼠，...
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IschemicNeuroprotectionWithSelective-OpioidReceptorAgonistIsGenderSpecific
...etofreperfusionandcontinuedfor22hours.Inthesecondexperiment,ovariectomized(OVX)femaleratsweretreatedwithvehicleorBRL.Infarctvolumeinthecortexandcaudoputamen(CP)complexwasassessedbytriphenyltetrazoliumchloridestainingat72hoursafterMCAO.ResultsInfarctvolume(percentageofipsilateralstructure;mean±SEM)w...
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他莫西芬对大鼠子宫内膜增殖和凋亡的影响
...手术组（SHAM组）、假手术+TAM组(SHAM+TAM组)、去势手术组（OVX组）、去势手术+TAM组（OVX+TAM组），每组10只，用药28天后，处死大鼠取子宫进行形态学检查，PCNA抗原免疫组化分析及TUNEL凋亡检测。结果他莫西芬可以使去势大鼠子宫湿...
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雌激素对双侧穹隆-海马伞切断及去势大鼠脑源性神经营养因子表达的影响
...建立4个模型组：穹隆-海马伞切断组(FF组)、卵巢切除组(OVX组)、卵巢切除加穹隆-海马伞切断组(OF组)和对照组，然后再建立OF组同时给予雌二醇(E2)治疗组(OF+E2组)和双侧穹隆-海马伞切断加卵巢切除对照组，每组5只。E2剂量为1mg/kg，...
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IL-6在绝经后骨质疏松症发病机制中的作用研究进展
...作一综述。1药理研究王宝利等［2］为了研究尼尔雌醇对OVX大鼠IL-6mRNA表达水平的影响，探讨绝经后骨质疏松的分子细胞学机制。将30只3月龄雌性Wistar大鼠随机分成三组，每组10只，即OVX组、假手术组和尼尔雌醇组。对OVX组和尼尔...
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续断对去势大鼠骨量和血清IGF-Ⅰ的影响ˇ
...标的影响。方法12月龄雌性SD大鼠随机分为空白对照组（OVX）、雌激素对照组（OVX+E）、续断1、2、3组（OVX+X1、X2、X3），卵巢切除后7天开始给药，术前和3个月后2次检测骨量，然后处死大鼠，检测血清IGF-Ⅰ、ALP、Ca和P。结果空白...
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17-Estradiolreplacementimprovesrenalfunctionandpathologyassociatedwithdiabeticnephropathy
...inwomenandmen.Thisstudyexaminedtheeffectsofestrogendeficiencybyovariectomy(OVX)andreplacementwith17-estradiol(OVX+E2)onrenalfunctionandpathologyinthenondiabetic(ND)andstreptozotocin(STZ)-induceddiabetic(D)ratkidneysfor12wk.Diabeteswasassociatedwithanincreaseinurinealbuminexcretion(UAE;ND,0.39±0.03;...
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EstrogenTreatmentAbrogatesNeointimaFormationinHumanC-ReactiveProteinTransgenicMice
...cularinjuryintheCRPtgmouse.MethodsandResults—Intact(INT)orovariectomized(OVX)CRPtgandNTG,treatedwithE2orvehicle,hadtheirrightcommoncarotidarteryligated.ResultantneointimaformationwasexaggeratedinCRPtgcomparedwithNTG,whetherINTorOVX,butwaspreventedinbothgenotypesbyE2.ExpressionofhumanCRPprotein(imm...
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性激素紊乱对新生小鼠下颌骨内部结构的影响
...影响。他们分析了施行睾丸切除术（ORX）或卵巢切除术（OVX）的新生小鼠下颌骨的内部结构。40只5日龄C57BL/6J小鼠分别接受ORX、OVX和假手术。手术后8周，对每只小鼠的下颌骨进行组织形态测定分析，应用外周骨定量断层扫描仪（...
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激素替代对猴宫骶韧带和圆韧带生物力学特性的影响
...外科医师学院的VardyMD博士及其同事研究了卵巢切除术（OVX）和共轭马雌激素加宫安黄体酮（CEE/MPA）或乙炔基雌二醇加炔诺酮（EE/NA）对绝经后（PMP）猴宫骶韧带（USL）及圆韧带（RL）生物力学特性的影响。在这项随机三盲安慰剂...
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降钙素对骨性关节炎中软骨作用的研究进展
...现为轻度的浸润和蛋白多糖的丢失，出现软骨溃烂。但是OVX模型还是代表早期或者破坏性不强的疾病的，因此，OVX模型适合作为关节炎早期的研究〔18〕。汪韬等〔19〕对OVX大鼠进行研究，结果表明CT能阻止骨量的丢失，阻止椎间...
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甲状旁腺激素治疗去势大鼠颅骨缺损的研究
...monefragment134onbloodCa2+,PO43-andPTHconcentrationinovariectomizedrats(OVX).MethodsTwentyfour6monthWistarratsweredividedinto3groupsrandomly,sham,OVXandOVXtreatedbyPTH134.TheBoneMineralDensityof6ratsselectedrandomlywerevaluedandconfirmedosteoporosismodels.Theotherswith8mmdefectinskullwer...
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米索前列醇对去势后大鼠早期骨丢失的保护
...theinfluenceofmisoprostolonbonemineraldensity（BMD）inovariecˉtomized（OVX）rats.Methods30femaleWistarratsaged90dweredividedinto3groups:Sham，OVX，OVX+misoprostolwith10ratsineachgroup.TheOVX+misoprostolgroupwastreatedorally2mg/（kg·d）misoprostolafter28days.Allratsweresacrificedfortreatmen...
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再灌注早期应用雌二醇对缺血鼠心肌的保护作用
...，采用Langendorff离体鼠心脏灌注模型,将30只雌性卵巢切除(OVX)大鼠随机均分为3组。缺血再灌注组(I-R组)用K-H液预灌注15min,常温停灌30min,恢复K-H液再灌注30min；0.1%二甲基亚砜组(D组)和5μmol/LE2组(E组)从再灌注第6min起改用含相应药液的...
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再灌注早期应用雌二醇对缺血鼠心肌的保护作用
...，采用Langendorff离体鼠心脏灌注模型,将30只雌性卵巢切除(OVX)大鼠随机均分为3组。缺血再灌注组(I-R组)用K-H液预灌注15min,常温停灌30min,恢复K-H液再灌注30min；0.1%二甲基亚砜组(D组)和5μmol/LE2组(E组)从再灌注第6min起改用含相应药液的...
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局部注射缓释型bBMP对去势绵羊椎体骨骼影响的研究
...松椎体骨强度的局部治疗方法。研究者采用卵巢切除法（OVX）对6只成年雌性绵羊去势，低钙饲养1年后，经双能X线吸收骨密度测量仪检测后确定建立骨质疏松模型。采用拉丁方设计方案，通过经椎弓根注射途径，分别在每只动物...
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Lipidstandardizationofserumfat-solubleantioxidantconcentrations:theYALTAstudy
...analyzedasadependentvariableonlipoproteincharacteristicsbytheuseofaseriesofmodels.Model1containedonlyplasmatotalcholesterolasanindependentvariable.Model2hadonlyplasmaLDLcholesterol;model3hadplasmatotalcholesterolandVLDLcholesterol;model4hadplasmaLDL,HDL,andVLDLcholesterolsimultaneously.Notethatbecau...
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Associationbetweendietaryglycemicindex,glycemicload,andbodymassindexintheInter99study:isunderreportingaproblem?
...sweredefinedasthosehavinganEI/BMR1.14.UnivariateandmultiplelinearregressionmodelswereusedtotestforassociationsbetweenGI,GL,andBMI.Theconfoundersweresex,age,smoking,physicalactivity,alcoholintake,andenergyintake.Allanalyseswereconductedon1)theentirepopulationand2)asubsampleexcludingLERs.Results:Inthe...
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ATNFreceptorlooppeptidemimicblocksRANKligand-inducedsignaling,boneresorption,andboneloss
...fcharacteristicrepeatedcysteine-richdomains(CRDs)(25).Mutagenesis,molecularmodelingstudies,andcrystalstructuresofp55typeITNFR/TNF-?(22)andTRAIL/deathreceptor5(23,24)complexesindicatethatTNFRmembershave2ligandcontactsurfacesatconservedlocations(CRD2andCRD3intheTNFR).Whilethelocationsandgeneralnatureo...
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LowfolatestatusisassociatedwithimpairedcognitivefunctionanddementiaintheSacramentoAreaLatinoStudyonAging
...tisticalanalysisMultiplelinearregressionanalyseswereusedtobuild4statisticalmodelstodescribetheassociationsbetweenRBCfolateconcentration(independentvariable)andeachofthecognitivefunctiontestinstruments(dependentvariables)before(model1)andafteradjustmentforconfoundingbyhomocysteinealone(model2),byhomo...
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Relationsoftotalphysicalactivityandintensitytofitnessandfatnessinchildren:theEuropeanYouthHeartStudy
...er4consecutivedays(2weekdaysandatleast1weekendday)withanactivitymonitor(MTImodelWAM7164;ManufacturingTechnologyInc,Shalimar,FL,formerlyknownasComputerScienceandApplicationsInc)attachedontherighthip.Atleast3daysofrecording,withaminimumof10hregistrationperday,wassetasaninclusioncriterion.TotalPA(alsoc...
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Weight,shape,andmortalityriskinolderpersons:elevatedwaist-hipratio,nothighbodymassindex,isassociatedwithagreaterriskofdeath
...intilesbysex-specificquintilesandrelatedtomortalityriskbyusingCoxregressionmodels.Three-wayinteractionsweretestedbetweeneachanthropometricvariable(BMI,WHR,andWC)withsexandcurrentsmokingstatusforall-causeandcirculatorymortality.Allmodelswereadjustedforthelineareffectsofheightandage,whichwasconsidered...
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LipidprofilesinadolescentFilipinos:relationtobirthweightandmaternalenergystatusduringpregnancy
...ationduringpregnancyhaslong-termeffectsonlipidmetabolisminoffspringinanimalmodels(7,8),fewstudiesinhumanshaveinvestigatedthepossibleroleofmaternalnutritionduringpregnancyintheserelations(9).Ofthe3studiesofcholesterolthatincludedmarkersofmaternalnutritionalstatusduringpregnancy,poormaternalnutritiona...
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LongitudinalmeasuresofcirculatingleptinandghrelinconcentrationsareassociatedwiththegrowthofyoungPeruvianchildrenbutarenotaffectedbyzinc
...oreandafterthefeedingwithanelectronicinfantbalancewith5gprecision(BabyScalemodel231;Seca,Hamburg,Germany).Childrenwhowerenotbreastfeedingwerefedthetypicalnon-humanmilksubstituteusedinthiscommunity(reconstitutedevaporatedorpowderedcowmilk),andtheamountsofmilkandwaterwereweighedwithanelectronicbalance...