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昆明植物所等在植物基因组学研究上取得新进展
...基因组学方面的研究。进化树分析表明，杨树与葡萄中的OPT家族基因明显呈现出两个分枝，进一步可以细化成十个分枝；OPT家族基因在染色体中呈现非随机的串联重复方式分布，暗示基因重复在杨树与葡萄中适应性进化中的重要...
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武汉植物园揭示水分和钾素胁迫对棉花钾效率的影响
...为研究材料，采用盆栽实验，设置水分和钾素胁迫处理(OPT-W,OPT-K,OPT-W-K)和对照（OPT），对比分析在土壤水分及钾素养分胁迫条件下两个棉花品种生物量、产量、钾素吸收和分配等方面的差异。研究结果表明：干旱和低钾胁迫显著...
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热门留学国家纷推利好政策吸引或留住人才
...工程学以及数学这四类学位的外国留学生的实习工作期(OPT)将由目前的12个月延长到29个月。OPT时间的延长，意味着这四类留美学生将有更长时间、更多机会获得美国工作的经验。不过，享受这一新政策的外籍学生需满足以下条件...
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辉瑞潜在重磅药物tofacitinib2个III期研究达主要终点
...nus激酶（JAK）抑制剂tofacitinib的2项III期研究的顶级数据：OPTCompare(A3921080)和OPTRetreatment(A3921111)，这些研究是III期OPT（口服治疗银屑病）项目5个III期研究中的前2个研究，旨在调查tofacitinib治疗中度至重度慢性斑块牛皮癣成人患者的...
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快速上颌扩大术后即刻和一年后观察到的自然头位变化
...颅面角有显著变化。但是，在行扩大术一年后，NSL/VER、OPT/HOR和CVT/HOR分别减少了3.14度（P<0.01）、2.13度（P<0.05）和2.55度（P<0.05）。McGuinness博士等总结认为，该研究的结果提示，由于RME使呼吸方式发生变化，即由经口改为经鼻，...
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NER1006能够取得品质很高的清肠功效
...得品质很高的清肠功效。 Norgine的二期非盲随机研究(OPT,n=240)主要是调查研究，与MOVIPREP相比，分次给药之后的药效动力学特征（粪便重量），临床功效和剂量耐受性，以及口味有所改进的低剂量PEG（聚乙二醇）清肠配方(NER100...
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肿瘤药物敏感试验在胃癌临床化疗中的作用
...制药厂提供;顺铂（PDD），山东制药厂提供;羟基喜树碱（OPT），黄石飞云制药有限公司提供;表阿霉素（EPI），法玛西亚有限公司提供;泰素（TAX），百时美施贵宝公司提供;健择（Gemzar），法国礼来公司提供;氟尿脱氧核苷（Fudr）...
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Protease-ActivatedReceptorsDifferentiallyRegulateHumanPlateletActivationthroughaPhosphatidicAcid-DependentPathway
...romBDPharMingen(SanJose,CA).EDTA,trichloroaceticacid(TCA),o-phthalaldehyde(OPT),andchloroformwerepurchasedfromFisherScientificCo.(Pittsburgh,PA).Aggregometers,Chrono-lumereagent,andotheraggregationsupplieswerepurchasedfromChrono-LogCo.(Havertown,PA).HumanPlatelets.Humanplateletswereobtainedfromhealt...
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超级耐药菌占据上风催生新型抗生素
...司的利福昔明（rifaximin、Xifaxan）、Genzyme公司的tolevamer和Optime公司的OPT-80等许多药物已经开始与艰难梭菌作斗争。久经考验的老药亦可加入对抗赛虽然新作用机制的药物是与超级细菌作斗争最需要的，但那些经过考验的老药还是...
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角膜厚度与高眼压症及正常人眼压的关系探讨
...间的关系，并以CCT推测青光眼进展的危险性［１３］。Ｃopt等［１４］也报道，有许多高眼压症病人是角膜厚度较厚所致眼压高，而并无青光眼危险因素；部分正常眼压青光眼患者，眼压测量值正常为角膜厚度较薄所致，实际眼...
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电针对创伤组织局部肥大细胞数量及其组胺含量的影响
...三蒸水稀释一倍后加0.5ml0.4NNaOH碱化，混匀并迅速加入0.5%OPT甲醇液0.1ml，立即混匀并在21～22℃反应10min，加0.5ml0.5NHCl酸化以终止反应，在日本岛津F-510型荧光分光光度计上波长440nm/360nm处测定荧光强度。1.6统计学方法数据以均数±...
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Immunolocalisationofopticininthehumaneye
...ication15October2003ABSTRACTAim:Tolocalisetherecentlydiscoveredglycoproteinopticinintheadulthumaneye.Methods:Polyclonalrabbitantiserawereraisedagainsttwodifferentopticinpeptides.Isolatedhumanvitreouscollagenfibrilswereextractedwith8MureaandtheextractanalysedbySDS-PAGEandwesternblotting.Paraffinembed...
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DiagnosticPerformanceofDuplexUltrasoundinPatientsSuspectedofCarotidArteryDisease
...ientischemicattack(TIA),orminorstrokebasedon2criteria:maximizingaccuracyandoptimizingcost-effectivenessandtocomparethesewithcurrentrecommendations.Methods—FromJanuary1997toJanuary2000,aprospectivemulticenterstudywasconductedincluding350consecutivepatientswithsymptomsofamaurosisfugax,TIA,orminorstr...
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MicrobialRiskIndicatorsofEarlyChildhoodCaries
...iouslesions.Interproximalsurfacecarieswereassessedusingdigitalimagingfiber-optictransillumination(DIFOTI,Irvington,NY).About20%ofthetotalcohortwascariesfree,25%hadlowtomoderatelevelsofdentalcariesrates,and55%hadhightorampantcariesrates.Plaquesampleswerecollectedinthemorning,andthechildrenwereaskedno...
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CyclophilinAIsaProinflammatoryCytokinethatActivatesEndothelialCells
...esionmolecule-1.Furthermore,thecombinationofCyPAandcycloheximideinducedECapoptosissimilartotheproapoptoticeffectoftumornecrosisfactor-.Conclusions—OurdataindicatethatCyPAhasproinflammatoryeffectsonECandmayplayanimportantroleinthepathogenesisofinflammatorydiseases,suchasatherosclerosis.Thisworkdefi...
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无损光学法测量胃壁组织对KTP/Nd:YAG激光的光学特性的差异
...器；空间分辨漫反射光 NoninvasivemeasurementsfordifferencesinopticalpropertiesofstomachtissuesatKTP/Nd:YAGlaserusingopticalmethods WEIHua-jiang，XINGDa，HEBo-hua，etal. MOEKeyLaboratoryofLaserLifeScienceandInstituteofLaserLifeScience，SouthChinaNormalUniversity，Guangzho...
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Pathologicandphysiologicinteractionsofbacteriawiththegastrointestinalepithelium
...typhimuriuminteractswiththephysiologicreceptorforepidermalgrowthfactortoco-optthereceptor‘ssignaltransduc-tionmechanisms.EnteropathicEscherichiacolisecretesarecep-tor(typeIIIsecretion)intothemicrovillussurfaceofenterocytesthatdisruptsthemicrovillusandaltersitsactinstructuretoformadome-likeanchorin...
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AnatomicalMappingofWhiteMatterHyperintensities(WMH)
...nitiallyevenlyspacedlattices.Pisnotchanged,butpointsofQwillbeadjustedduringoptimization.Avoxellocationoftheunderlyingimagecanbeexpressedbybarycentriccoordinatesintermsofthe8-cornercontrollatticepointsofthelatticecubeinwhichitlies.EachpointinPorQisthecornerof8cubicalsubvolumesoftheunderlyingimagedefi...
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Whole-grainryeandwheatfoodsandmarkersofbowelhealthinoverweightmiddle-agedmen
...rolactone(47%and71%)andfecalbutyrate(26%and36%),relativetowheatandlow-fiberoptions,respectively.Conclusions:High-fiberryeandwheatfoodconsumptionimprovedseveralmarkersofbowelandmetabolichealthrelativetothatoflow-fiberfood.Fiberfromryeappearsmoreeffectivethanthatfromwheatinoverallimprovementofbiomarke...
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NonendothelialMesenchymalCell-DerivedMCP-1IsRequiredforFGF-2-MediatedTherapeuticNeovascularization
...loG,IlliB,TestolinL,GaetanoC,CapogrossiMC.Acidosisinhibitsendothelialcellapoptosisandfunctionandinducesbasicfibroblastgrowthfactorandvascularendothelialgrowthfactorexpression.CircRes.2000;86:312-318.HongKH,RyuJ,HanKH.MCP-1-inducedangiogenesisismediatedbyVEGF-A.Blood.2005;105:1405-1407.YamadaM,KimS,E...
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强脉冲光的基础研究和临床应用
...hellip;44%(180/181)。李东妮等［15］采用波长介于515～1200nm的OPT治疗仪治疗咖啡斑98例，每次治疗间隔3～5周，4次为1个疗程，观察临床疗效及不良反应。结果：98例患者，治愈58例，显效28例，有效7例,总有效率96.93%。5例复发,复发率5....
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第三节 微量元素的作用及其与疾病的关系
...（Fe）比色法男80-200μg/dl缺铁性贫血再生障碍性贫血 （OPT法）女70-180μg/dl出血性贫血铁粒幼细胞贫血 Banti综合征血色沉积病 慢性感染急性肝炎早期 肿瘤等 铜（Cu）比色法男80-130μg/dlWilson病毛细胆管性肝炎 ...
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Protectionofrenalcellsfromcisplatintoxicitybycellcycleinhibitors
【摘要】Theoptimaluseofcisplatinasachemotherapeuticdrughasbeenlimitedbyitsnephrotoxicity.Murinemodelshavebeenusedtostudycisplatin-inducedacuterenalfailure.Aftercisplatinadministration,cellsoftheS3segmentintherenalproximaltubuleareespeciallysensitiveandundergoextensivenecrosisinvivo.Similarly,cul...
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TheHostInflammatoryResponsePromotesLiverMetastasisbyIncreasingTumorCellArrestandExtravasation
...cellsandendothelialVCAM-1orPECAM-1(Figure7C),suggestingthattumorcellscanco-optmolecularmediatorsofleukocyteadhesionandtransmigrationtoattachtothehepaticendothelialcells.51CX-1adhesionincloseproximitytovascularE-selectinwasalsoobserved(Figure5B),consistentwiththehighexpressionofsialylatedglycoprotein...
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ExtracellularProteasesinAtherosclerosisandRestenosis
...lation,receptorshedding,enhancingcellmigration,proliferation,invasion,andapoptosis.Thisreviewdiscussesextracellularproteasesrelevanttothevasculature,theirclassificationandfunction,andhowproteasedisorderscontributetoarterialplaquegrowth,includingchronicatherosclerosis,acutecoronarysyndromes,restenosi...
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AT1receptorblockadepreventsinterstitialandglomerularapoptosisbutnotfibrosisinpigswithneonatalinducedpartialunilateralureteralobstruction
...end-stagerenalfailureinchildren.Thepathophysiologicalmechanismsmayinvolveapoptosisandtherenin-angiotensinsystem.Westudiedapoptosisandfibrosisinawell-establishedneonatalpigmodelwithunilateralpartialureteralobstruction(PUUO)inducedduringongoingnephrogenesisin2-day-oldpiglets.TheroleofangiotensinII(ANG...
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DistinctRolesofEphrin-B2ForwardandEphB4ReverseSignalinginEndothelialCells
...ing.b-Endcellsplatedinthepresenceorabsenceof25µmol/Lo-phenanthrolene(OPT)onimmobilizedephrin-B2-Fcprotein.Thesecellswerethenplatedfortheindicatedtimes. Itwasreportedthatephrin-A2formsastablecomplexwiththemetalloproteaseKuzbanianintheabsenceofEphAreceptorsandthatwhenephrin-A2ligandbindstotheE...
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NitricOxideandEndoplasmicReticulumStress
...ts.However,alargeamountofNOistoxictothehostandcausesseveraldiseasessuchasapoptosis,septicshock,anddiabetesmellitus.Inducible-formNOsynthaseisinducedininflammatorydiseases,includinginsulitisandarteriosclerosis.Endoplasmicreticulum(ER)stresspathwaywasfirstidentifiedasacellularresponsepathwayinducedbyt...
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NeuroprotectiveandBlood-RetinalBarrier-PreservingEffectsofCannabidiolinExperimentalDiabetes
...ions13,14andindiabeticretinas.15,16Activationofp38MAPkinaseisimplicatedinapoptoticdeathofretinalganglioncells17andinN-methyl-D-asparticacid(NMDA)-inducedneuralretinaldeath.18Activationofp38MAPkinasehasalsobeenimplicatedinvascularhyperper-meabilityindiabeticretinas19andinVEGF-inducedpermeability.20,2...
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N3-MethyladenineInducesEarlyPoly(ADP-Ribosylation),ReductionofNuclearFactor-BDNABindingAbility,andNuclearUp-RegulationofTelomeraseActivity
...hebaseexcisionrepair(BER),thecombinationofMe-Lex+PARP-1inhibitortriggeredapoptosisasaresultofdisruptionofBERprocess.Inconclusion,thepresentstudyprovidesnewinsightintothecellularresponsetoN3-adenine-selectivemethylatingagentsthatcanbeexploitedforthetreatmentoftumorsunresponsivetoclassicalwide-spectru...