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镰刀菌毒素DON、NIV的细胞毒性和致突变、致畸、致癌研究进展
摘要 脱氧雪腐镰刀菌烯醇（dON）、雪腐镰刀菌烯醇（nIV）均属于单端孢霉烯族毒素，是赤霉病麦中最常检出的毒素，常常单独或联合污染粮谷类。它们主要由某些镰刀菌产生，可对人类和不同种属的动物产生广泛的毒性效应。...
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无创通气在慢性阻塞性肺疾病急性加重期的临床应用
...创通气 慢性阻塞性肺疾病 急性加重期 无创通气（NIV）通常是指通过鼻、面罩或相似装置经过上呼吸道给予通气支持的方法［1］。20世纪90年代后期逐步成为慢性阻塞性肺疾病（COPD）及慢性阻塞性肺疾病急性加重（AECOPD）...
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无创正压通气治疗呼吸衰竭的护理
...选择，适当的体位与面罩的松紧度，严格的气道管理是行NIV的前提，血气、生命体征、神志，呼吸机工作状况以及并发症的监护是行NIV的重点。关键词无创正压通气呼吸衰竭护理随着对有创通气所带来严重副作用认识的深入以及...
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急性呼吸衰竭使用无创通气治疗
...急诊室（ED）的急性呼吸衰竭（ARF）患者使用无创通气（NIV）做了一项研究。共有190名ARF患者在ED接受了200次的NIV。发现NIV的主要适应症为心源性肺水肿(CPE)(70次)，COPD急性加剧(39)，CPE合并COPD急性加剧(11)，肺炎(48),肥胖/通气不足...
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无创机械通气在慢性阻塞性肺疾病急性呼吸衰竭患者中的应用价值
【摘要】目的探讨无创机械通气（NIV）在慢性阻塞性肺疾病急性加剧致急性呼吸衰竭患者中的应用价值。方法20例重度高碳酸血症呼吸衰竭（HRF）患者进行双水平气道正压通气（BiPAP）,监测治疗前后动脉血气（pH、PaCO2、PaO2）。...
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蛋白质突变“导致病毒传播”
...要集中在南方的喀拉拉邦。来自印度国立病毒学研究所（NIV，位于印度Pune）的科学家上个月（11月）在印度科学院的一场会议上报告说，他们并没有在印度的样本中发现留尼旺岛的突变。NIV的科学家VidyaArankalle说她和同事发现了...
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ALS病患病程恶化减缓、存活较久
...外，该组有许多病患服用riluzole药物和接受非侵犯性呼吸(NIV)治疗。 另一方面，历史组病患较年轻，开始时之AALSS较低，较常接受经皮穿刺胃引流(PEG)治疗。 不过，忽略这两组病患之差异，多变项分析显示历年来...
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无创机械通气在危重病医学中的应用
...分为有创机械通气和无创机械通气（non-invasiveventilation，NIV），前者指通过气管插管或气管切开术建立人工气道，后者不需要建立人工气道，相比之下，无创机械通气更符合人体的生理状态，具有损伤小、继发感染机会少、上机...
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无创呼吸机治疗慢性阻塞性肺病合并呼吸衰竭的护理
...的气道护理是机械通气成功与否的关键。无创正压通气(NIV)是指除气管切开、气管插管以外的无创伤机械通气的呼吸支持模式。NIV在COPD呼吸衰竭的患者应用越来越普遍，不仅能减轻患者的痛苦，提高生活质量，而且提高有创通气...
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PCRProtocolforSpecificIdentificationofCandidanivariensis,aRecentlyDescribedPathogenicYeast
DepartmentofMicrobiology,HospitalUniversitarioN.S.deCandelaria,SantaCruzdeTenerife,CanaryIslands,SpainResearchInstitute,HospitalUniversitarioN.S.deCandelaria,SantaCruzdeTenerife,CanaryIslands,SpainDepartmentofCellularBiologyMicrobiology,UniversityofLaLaguna,CanaryIslands,SpainUnitatdeMicrobiologia,F...
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VegetarianNutrition
...ntheirreproductiveyears,elderlyindividuals,andathletes.The4chaptersinsectionIVdiscussrecommendationsforhealthyvegetariandietsandreviewthepossiblenutrientsofconcerninvegetariandiets,thehealth-promotingaspectsofphytochemicals,theguidelinesforchronicdiseaseprevention,andthedevelopmentofavegetarianfoodg...
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采用同位素稀释法串联质谱的方法同时测定玉米中的多种霉菌毒素
...品安全。单端孢霉烯族B类毒素（DON、FUSX、3-ADON、15-ADON、NIV），以及OTA、OTB、MON、ZON、ZAN等是最为普遍存在的污染真菌。下面列出10种霉菌毒素的结构式见图1。如果食用含上述毒素的谷物食品，则会产生极大的毒副作用。单端孢...
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美人工合成抗艾新药外源凝集素
...发现其抗病毒能力在果糖中完全无损。“这种多聚物在抗NIV方面非常有效，将一块方糖大小的BzB多聚物溶化在一浴缸的水中，其浓度足以阻止HIV感染细胞。”基瑟说，“理想的抗HIV杀菌素包括效能、广谱性、选择抑制性、生物产...
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EarlyNoninvasiveVentilationAvertsExtubationFailureinPatientsatRisk
...nsiva,HospitalClinic,Institutd‘InvestigacionsBiomediquesAugustPiiSunyer,UniversitatdeBarcelona,Barcelona,SpainABSTRACTRationale:Respiratoryfailureafterextubationandreintubationisassociatedwithincreasedmorbidityandmortality.Objectives:Toassesstheefficacyofnoninvasiveventilationinavertingrespiratory...
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PurificationandCharacterizationofNipahVirusNucleocapsidProteinProducedinInsectCells
...iology,FacultyofBiotechnologyandBiomolecularSciencesInstituteofBioscience,UniversitiPutraMalaysia,43400Serdang,Selangor,MalaysiaABSTRACTThenucleocapsid(N)proteinofNipahvirus(NiV)isamajorconstituentoftheviralproteinswhichplayaroleinencapsidation,regulatingthetranscriptionandreplicationoftheviralgenom...
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王居易经络医学心经与心包经主病新解
...说明心包经与心肌供血系统有直接关联。 病例2 Niv.女，53岁，以色列人。近两月夜间睡觉出现呼吸暂停、打鼾。患者有高血压史6年（150/100mmHg），发作性眩晕。察经手足少阴、足太阳异常。脉象沉细，偶发早搏。 取...
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无创通气在慢性阻塞性肺疾病合并呼吸衰竭中的应用
...认识和机械通气技术的进步，经鼻/面罩实施无创通气（NIV）逐渐增多［1，2］。近年广泛开展无创通气治疗COPD合并轻、中度Ⅱ型呼吸衰竭，可以改善患者的氧合功能和通气功能，纠正缺O2和CO2潴留，及时纠正呼吸衰竭，减少有创...
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鼻咽癌病人的颅神经恢复因素探讨
...dwithtwohundredandforty-fivecranialnervedeficitsweretreatedinourhospital.U-nivariateandmultivariateCoxmodelanalysiswereusedtoevaluatethefactorsinfluencingtherecoveryofabnormalcranialnerves.ResultsCompleterecoveryrates，partial-recoveryrateandno-changeratewere65.7%（161/245），19.2%（47/245）...
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BiPAP呼吸机在慢性阻塞性肺病合并Ⅱ型呼吸衰竭治疗中的应用
...科常见、多发病，患病率和病死亡率均较高。无创通气(NIV)在临床广泛应用，无创正压机械通气(BiPAP)无需人工气道，患者耐受较好，并发症较少，成为治疗COPD合并呼吸衰竭的主要方法。现对南充市中心医院呼吸内科普通病房BiPAP...
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金雀异黄素体外对猪脑微管蛋白聚合的影响
...nhibitoronpro-liferationofhumankeratinocytesculturedinvitro.JFourthMilMedU-niv，2001，85（22）:2020-2022.3YanashitaY，Hasegawa-SasakiH，SasakiT，etal.SuppressionbystaurosporincofCa（2+）mobilizationtriggeredbyligationofantigen-specidicreceptorsonTandBlymphocytesAnessentialroleofproteintyros...
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南通市儿童单纯性肥胖及其影响因素分析
...WANGJie，XUJi-da，MOBao-qing，etal. KangdaSchoolofNanjingMedicalU-niverisity，Jiangsu（210029），China 【Abstract】ObjectiveTostudytheprevalenceandriskfactorsofsimpleobesityamongchildreninNantong，andtoprovideevidencefortheinter-ventionmeasuresagainstchildren‘sobesity.MethodsTh...
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Species-SpecificFibroblastsRequiredforTriggeringInvasivenessofPartiallyTransformedOralKeratinocytes
...uresofDOKonhumanfibroblast-containingmatrix(P0.05).DepositionofhumancollagenIVwasobservedatepithelial-matrixinterfaceonlywhenDOKbehavedinvasively.Inconclusion,invasionofpartiallytransformedoralkeratinocyteswastriggeredbykeratinocyte-inducedfibroblast-deriveddiffusiblefactor(s)inaspecies-specificmann...
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PhysiologicEffectsofNoninvasiveVentilationduringAcuteLungInjury
...acutelunginjury(ALI)(1),earlyinstitutionofnoninvasivemechanicalventilation(NIV)mayreversetheacuteepisode,obviatingendotrachealintubation(2,3).Nevertheless,switchingtoinvasiveventilationisrequiredinmorethan40to50%ofhypoxemicpatientsreceivingNIVinobservationalstudies(4–7).Physiologicdataareneededtoa...
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One-yearOutcomeafterSeverePulmonaryExacerbationinAdultswithCysticFibrosis
...spitalierCochin,AssistancePubliqueHpitauxdeParis,FaculteeCochinPort-Royal,UniversiteeParis5,Paris,FranceABSTRACTWeretrospectivelystudiedtheoutcomesofadultpatientswithcysticfibrosis(CF)hospitalizedforseverepulmonaryexacerbations(69cases)betweenJanuary1997andJune2001.CasesweretreatedeitherinthePulmona...
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TGF-1inducesIL-8andMCP-1throughaconnectivetissuegrowthfactor-independentpathway
【关键词】growth1DepartmentofMedicine,KollingInstitute,UniversityofSydney,RoyalNorthShoreHospital,Sydney2DepartmentofMedicine,UniversityofSydneyRoyalPrinceAlfredHospital,Sydney3DepartmentofMedicine,St.Vincent‘sHospital,Melbourne,AustraliaDepartmentofMedicine,UniversityofToronto,St.Michael‘s...
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Solublebetaglycanreducesrenaldamageprogressionindb/dbmice
...wereassociatedwithlowerkidneylevelsofmRNAsencodingTGF-1,TGF-2,TGF-3,collagenIV,collagenI,fibronectin,andserumglucocorticoidkinaseaswellasareductionintheimmunostainingofcollagenIVandfibronectin.OurdataindicatethatSBGisarenoprotectiveagentthatneutralizedTGF-actionsinthismodelofnephropathy.BecauseSBGha...
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Glucose-6-PhosphateDehydrogenaseDeficiencyDecreasesVascularSuperoxideandAtheroscleroticLesionsinApolipoproteinE-/-Mice
...ra-arterialmeasurementsinconsciousmice.29TheprotocolwasapprovedbytheBostonUniversityMedicalCenterInstitutionalAnimalCareandUseCommittee.MeasurementofSerumCholesterolAt21weeksofage,micewereanesthetizedwithisofluraneandblood,aorta,heart,andliverwereremoved.Serumcholesterolwasmeasuredenzymaticallyusing...
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AtherosclerosisinMiceIsNotAffectedbyaReductioninTissueFactorExpression
...position.MethodsMiceAllstudieswereapprovedbyTheScrippsResearchInstituteandUniversityofMichiganAnimalCareandUseCommitteesandcomplywithNationalInstituteofHealthGuidelines.TheapoE-deficient(apoE-/-)miceonaC57Bl/6JbackgroundwerepurchasedfromJacksonLaboratories(BarHarbor,Me).Low-TFmiceexpressverylowlevel...
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RegulatedExpressionoftheCXCRLigandKC/GRO-inAtheroscleroticLesionsPlaysaCentralRoleinMacrophageAccumulationandLesionProgression
...atedwithrabbitanti-mouseCXCR2antibody(agenerousgiftofDr.N.Mukaida,KanazawaUniversity,Japan)for30minutesfollowedbyincubationwithfluoresceinisothiocyanate-labeledrabbitIgGsecondaryantibody.ThestainedcellswereanalyzedonaBectonDickinson(MountainView,CA)fluorescence-activatedcellsorting(FACS)systemequipp...
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Temporalexpressionprofileanddistributionpatternindicatearoleofconnectivetissuegrowthfactor(CTGF/CCN-2)indiabeticnephropathyinmice
...ialmatrixscoreafter2wk.Increasedrenalfibronectin,fibronectinED-A,andcollagenIV1expression,aswellaselevatedplasmacreatininelevels,wereobservedafter9wk.After2wk,CTGFmRNAwasupregulatedthreefoldintherenalcortex.By9wk,CTGFmRNAwasalsoincreasedintheheartandliver.Incontrast,transforminggrowthfactor-1mRNAcon...