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AMP-activatedproteinkinasesignalinginmetabolicregulation
...hatisregulatedbycarnitinepalmitoyltransferase1(CPT1).CPT1transferslong-chainacyl-CoAintothemitochondria,andthisprocessisinhibitedallostericallybymalonyl-CoA(35),synthesizedbyacetyl-CoAcarboxylase(ACC)(36).TheactivityofACCisregulatedbyreversiblephosphorylation,andAMPKdirectlyphosphorylatesandinactiva...
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SequelaeofInsulin-ResistantAdiposeTissue
...naddition,intracellularproteinsthatbindorchemicallymodifyFA,suchaslong-chainacyl-CoAsynthetase(ACLS),35,36areverylikelytofacilitatethenettransportofFAfromtheplasmaintohepatocytes.IncreasedplasmaFAfluxtotheliverasacauseofincreasedVLDLapoBandTGsecretionhasbeenobservedbothinvitroandinvivo.37eC39Studies...