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植物酶类源自非酶物质
...都是从蛋白质进化而来。来自萨克生物研究学院的JosephP.Noel及同伴将注意力集中在寻找一种新陈代谢酶类的进化过程上，这种酶的前身仅是一类无任何活性的蛋白质。这种酶被称为查尔酮异构酶（chalconeisomerase，CHI），它对一类...
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MolecularCloningExpressionSelf-Assembly,Antigenicity,andSeroepidemiologyofaGenogroupIINorovirusIsolatedinFrance
...andECOS-Nord(no.CF99S01). REFERENCESTopAbstractTextReferencesAndo,T.,J.S.Noel,andR.L.Fankhauser.2000.GeneticclassificationofNorwalk-likeviruses.J.Infect.Dis.181(Suppl.2):S336-S348.Belliot,G.,J.S.Noel,J.F.Li,Y.Seto,C.D.Humphrey,T.Ando,R.I.Glass,andS.S.Monroe.2001.Characterizationofcapsidgenes,expre...
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MultiprefecturalSpreadofGastroenteritisOutbreaksAttributabletoaSingleGenogroupIINorovirusStrainfromaTouristRestaurantinNagasaki,Japan
...edbyNVsintouriststravelingbybusbetweentheUnitedStatesandCanada.Furthermore,Noeletal.(25)reportedthatNVoutbreaksduetoasinglevirusoccurredinsevencountriesonfivecontinentsduringthe1995-1996season,suggestingthatthecirculationofthestrainsmightinvolvepatternsoftransmissionnotpreviouslyconsidered.Food-born...
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MolecularEpidemiologyofCalicivirusesDetectedinSporadicandOutbreakCasesofGastroenteritisinFrancefromDecember1998toFebruary2004
...cription-PCRandSouthernhybridization.J.Clin.Microbiol.33:64-71.Ando,T.,J.S.Noel,andR.L.Fankhauser.2000.Geneticclassificationof“Norwalk-likeviruses.“J.Infect.Dis.181(Suppl.2):S336-S348.Bon,F.,K.Balay,L.LeCoustumier,P.Megraud,P.LeCann,A.Gallay,P.Pothier,andE.Kohli.Waterborneoutbreakofacutegastroen...
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匹维溴胺治疗肠易激综合征的临床观察
...肠易激综合征有关的腹痛、排便紊乱、肠道不适等症状。Noel［11］报道了一个大规模、公开的多中心临床观察，评估了匹维溴胺对IBS的治疗效果。1537例IBS患者应用匹维溴胺治疗，结果表明匹维溴胺能显著改善IBS患者的胃肠功能...
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植物生产脂肪酸的机制
...包括ω-3脂肪酸等。ω-3脂肪酸是重要的植物和人类福祉。Noel和同事们的研究表明查耳酮异构酶编码基因的变化会对植物生殖有变化。由于查尔酮异构酶的基本研究已过了十年，现在正出效益的时候，研究人员认为查尔酮异构酶蛋...
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BroadlyReactiveNestedReverseTranscription-PCRUsinganInternalRNAStandardControlforDetectionofNorovirusesinStoolSamples
...echniqueandrequiresexpertiseinrecognizingthesmallviralparticles(12),andimmunoelectronmicroscopy,whichneedsantiseraormonoclonalantibodiesavailableonlyinreferencelaboratories(2).Onlyinthepastdecadehastheknowledgeofthenucleotidesequenceandthegenomicorganizationofseveralstrainsofnorovirusesledtothedevel...
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GeneticAnalysisofNorovirusesinChibaPrefecture,Japan,between1999and2004
...seasesfromtheMinistryofHealth,LaborandWelfareofJapan.REFERENCESAndo,T.,J.S.Noel,andR.L.Fankhauser.2000.Geneticclassificationof“Norwalk-likeviruses.“J.Infect.Dis.181(Suppl.2):S336-S348.Berke,T.,B.Golding,X.Jiang,D.W.Cubitt,M.Wolfaardt,A.W.Smith,andD.O.Matson.1997.Phylogeneticanalysisofthecalicivi...
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Adose-dependentrequirementfortheprolinemotifofCD28incellularandhumoralimmunityrevealedbyatargetedknockinmutant
...atoryrequirementsinCD28-deficientmice.Science.261:609–612.Green,J.M.,P.J.Noel,A.I.Sperling,T.L.Walunas,G.S.Gray,J.A.Bluestone,andC.B.Thompson.1994.AbsenceofB7-dependentresponsesinCD28-deficientmice.Immunity.1:501–508.Noel,P.J.,L.H.Boise,J.M.Green,andC.B.Thompson.1996.CD28costimulationpreventscel...
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CharacterizationofNewRecombinantNoroviruses
...virusamongsnowmobilers—Wyoming,2001.J.Infect.Dis.187:303-306.Ando,T.,J.S.Noel,andR.L.Fankhauser.2000.Geneticclassificationof“Norwalk-likeviruses.“J.Infect.Dis.181(Suppl.2):S336-S338.Bon,F.,H.Giraudon,C.Sancey,C.Barranger,M.Joannes,P.Pothier,andE.Kohli.2004.Developmentandevaluationofanewcommerc...
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MolecularEpidemiologyofNorovirusInfectionsinStockholm,Sweden,duringtheYears2000to2003:AssociationoftheGGIIbGeneticClusterwithInfectionin
...esbysolid-phaseimmuneelectronmicroscopy.Arch.Virol.135:217-226.Ando,T.,J.S.Noel,andR.L.Fankhauser.2000.Geneticclassificationof“Norwalk-likeviruses.“J.Infect.Dis.181(Suppl.2):S336-S348.Büchen-Osmond,C.(ed.).2003.Caliciviridae.InICTVdB—theuniversalvirusdatabase,version3.ColumbiaUniversity,Oracl...
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UseofaHeminestedReverseTranscriptasePCRAssayforDetectionofAstrovirusinEnvironmentalSwabsfromanOutbreakofGastroenteritisinaPediatricPrim
...dbyreversetranscriptase-polymerasechainreaction.J.Infect.Dis.172:1437-1444.Noel,J.,andD.Cubitt.1994.IdentificationofastrovirusserotypesfromchildrentreatedattheHospitalsforSickChildren,London1981-93.Epidemiol.Infect.113:153-159.Noel,J.S.,T.W.Lee,J.B.Kurtz,R.I.Glass,andS.S.Monroe.1995.Typingofhumanast...
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ComparisonofaNewCommercialTest,GLABRATARTT,withaDipstickTestforRapidIdentificationofCandidaglabrata
...laboratory:phenotypicalmethods.Med.Mycol.39:9-33.Freydiere,A.M.,F.Parant,F.Noel-Baron,M.Crepy,A.Treny,H.Raberin,A.Davidson,andF.C.Odds.2002.IdentificationofCandidaglabratabya30-secondtrehalasetest.J.Clin.Microbiol.40:3602-3605.Freydiere,A.M.,R.Robert,C.Ploton,A.Marot-Leblond,F.Monerau,andF.Vandenesc...
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PrevalenceofNorovirusamongVisitorsfromtheUnitedStatestoMexicoandGuatemalaWhoExperienceTraveler‘sDiarrhea
...eler‘sdiarrhea.N.Engl.J.Med.328:1821-1827.Fankhauser,R.L.,S.S.Monroe,J.S.Noel,C.D.Humphrey,J.S.Bresee,U.D.Parashar,T.Ando,andR.I.Glass.2002.Epidemiologicandmoleculartrendsof“Norwalk-likeviruses“associatedwithoutbreaksofgastroenteritisintheUnitedStates.J.Infect.Dis.186:1-7.Fankhauser,R.L.,J.S.N...
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左心衰竭右室压力训练动物实验的病理学观察
...练，是为了解右心室是否可以适应高压环境。本研究采用Noel应用的肺动脉环缩法来实现右心室压力超负荷［5］，有文献报道，在肺动脉环缩后96h右心室就能够肥厚［6］，肺动脉环缩6天后右心室心肌细胞直径增大，右心室壁厚...
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质子放射治疗与颅底脊索瘤
...与光子束的混合照射，可进一步改善颅底脊索瘤的预后。Noel报道34例颅底脊索瘤采用光子束照射，剩余1/3剂量采用质子束缩野加量照射，总剂量60～70cGE。GTV平均总剂量限制在67cGE。中位随访30.5个月(2～56个月)，脊索瘤的3年局部...
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OutbreaksofGastroenteritisThatOccurredduringSchoolExcursionsinKoreaWereAssociatedwithSeveralWaterborneStrainsofNorovirus
...M.A.Drebot,S.A.Jenkerson,E.Funk,M.D.Sobsey,O.D.Simmons,S.S.Monroe,T.Ando,J.Noel,M.Petric,J.P.Middaugh,andJ.S.Spika.1997.Outbreakofviralgastroenteritisduetoacontaminatedwell.JAMA278:563-568.Boccia,D.,A.E.Tozzi,B.Cotter,C.Rizzo,T.Russo,G.Buttinelli,A.Caprioli,M.L.Marziano,andF.M.Ruggeri.2002.Water-bor...
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AroleforIgGimmunecomplexesduringinfectionwiththeintracellularpathogenLeishmania
...facesofmacrophageactivation.J.Leukoc.Biol.73:209–212.Sutterwala,F.S.,G.J.Noel,R.Clynes,andD.M.Mosser.1997.Selectivesuppressionofinterleukin-12inductionaftermacrophagereceptorligation.J.Exp.Med.185:1977–1985.Sutterwala,F.S.,G.J.Noel,P.Salgame,andD.M.Mosser.1998.Reversalofproinflammatoryresponsesb...
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StructuralbasisforthefunctionandregulationofthereceptorproteintyrosinephosphataseCD45
...sphatase.Biochemistry.38:914–922.Bilwes,A.M.,J.denHertog,T.Hunter,andJ.P.Noel.1996.Structuralbasisforinhibitionofreceptorprotein-tyrosinephosphatase-alphabydimerization.Nature.382:555–559.Desai,D.M.,J.Sap,J.Schlessinger,andA.Weiss.1993.Ligand-mediatednegativeregulationofachimerictransmembranerec...
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ApplicationofaMolecularPanelToDemonstrateEnterotropicVirusSheddingbyHealthyandHumanImmunodeficiencyVirus-InfectedPatients
...nreactionforrapiddiagnosisofenterovirusinfection.J.Virol.Methods48:155-166.Noel,J.S.,T.W.Lee,J.B.Kurtz,R.I.Glass,andS.S.Monroe.1995.Typingofhumanastrovirusesfromclinicalisolatesbyenzymeimmunoassayandnucleotidesequencing.J.Clin.Microbiol.33:797-801.Okitsu-Negishi,S.,T.A.Nguyen,T.G.Phan,andH.Ushijima....
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MulticenterEvaluationofaCandidaalbicansPeptideNucleicAcidFluorescentInSituHybridizationProbeforCharacterizationofYeastIsolatesfromBloodCu
...laboratory:phenotypicalmethods.Med.Mycol.39:9-33.Freydiere,A.M.,F.Parant,F.Noel-Baron,M.Crepy,A.Treny,H.Raberin,A.Davidson,andF.C.Odds.2002.IdentificationofCandidaglabratabya30-secondtrehalasetest.J.Clin.Microbiol.40:3602-3605.Gutierrez,J.,P.Morales,M.A.Gonzalez,andG.Quindos.2002.Candidadubliniensis...
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NorovirusesasaCauseofTraveler‘sDiarrheaamongStudentsfromtheUnitedStatesVisitingMexico
...,randomizedtrial.Ann.Intern.Med.106:216-220.Fankhauser,R.L.,S.S.Monroe,J.S.Noel,C.D.Humphrey,J.S.Bresee,U.D.Parashar,T.Ando,andR.I.Glass.2002.Epidemiologicandmoleculartrendsof“Norwalk-likeviruses“associatedwithoutbreaksofgastroenteritisintheUnitedStates.J.Infect.Dis.186:1-7.Gorbach,S.L.,B.H.Kean...
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RapidIdentificationofCandidaglabratawithaNewCommercialTestGLABRATARTT
...boratory:phenotypicalmethods.Med.Mycol.39:9-33.Freydière,A.-M.,F.Parant,F.Noel-Baron,M.Crepy,A.Treny,H.Raberin,A.Davidson,andF.C.Odds.2002.IdentificationofCandidaglabratabya30-secondtrehalasetest.J.Clin.Microbiol.40:3602-3605.Fricker-Hidalgo,H.,S.Orenga,B.Lebeau,H.Pelloux,M.P.Brenier-Pinchart,P.Amb...
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ComparisonoftheCOBASAMPLICORMTBandBDProbeTecETAssaysforDetectionofMycobacteriumtuberculosisinRespiratorySpecimens
...bacteriumtuberculosiscomplex.Mol.Cell.Probes7:395-404.Thierry,D.,A.Brisson-Noel,V.Vincent-Levy-Frebault,S.Nguyen,J.-L.Guesdon,andB.Gicquel.1990.CharacterizationofaMycobacteriumtuberculosisinsertionsequence,IS6110,anditsapplicationindiagnosis.J.Clin.Microbiol.28:2668-2673.Thomsen,V.O.,A.Kok-Jensen,M....
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Self-AssemblyoftheRecombinantCapsidProteinofaBovineNorovirus(BoNV)intoVirus-LikeParticlesandEvaluationofCross-ReactivityofBoNVwithHumanN
...a/269/93/US,andHu/Noro/II/MD145/87/US,didnotreactwiththeBoNVGIII/2reagents.Noeletal.(41)reportedhomologousimmuneresponsestoNorwalkvirusinpatientsinfectedwithothernorovirusGIstrainswithasmuchas38.5%aminoaciddivergenceintheN-terminalsequenceofthecapsidgene.However,homologousimmuneresponsestotheToronto...
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TestingforInductionofClindamycinResistanceinErythromycin-ResistantIsolatesofStaphylococcusaureus
...HealthServiceortheU.S.DepartmentofHealthandHumanServices.REFERENCESBrisson-Noel,A.,P.Delrieu,D.Samain,andP.Courvalin.1988.InactivationoflincosaminideantibioticsinStaphylococcus.IdentificationoflincosaminideO-nucleotidyltransferasesandcomparisonofthecorrespondingresistancegenes.J.Biol.Chem.263:15880-...
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Eotaxin-3andauniquelyconservedgene-expressionprofileineosinophilicesophagitis
...sinophiliainchildrenwithdysphagia.J.Pediatr.Gastroenterol.Nutr.37::498-503.Noel,R.J.,Putnam,P.E.,andRothenberg,M.E.2004..Eosinophilicesophagitis.N.Engl.J.Med.351::940-941.Kelly,K.J.etal.1995..Eosinophilicesophagitisattributedtogastroesophagealreflux:improvementwithanaminoacid-basedformula.Gastroente...
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GelsolinSecretioninInterleukin-4–treatedBronchialEpitheliaandinAsthmaticAirways
...nbronchialepithelialcells.AmJPhysiolLungCellMolPhysiol2002;282:L226–L236.Noel-GeorisI,BernardA,FalmagneP,WattiezR.Databaseofbronchoalveolarlavagefluidproteins.JChromatogrBAnalytTechnolBiomedLifeSci2002;771:221–236.MagiB,BiniL,PerariMG,FossiA,SanchezJC,HochstrasserD,PaesanoS,RaggiaschiR,SantucciA...
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第一节 免疫细胞化学技术在肾脏疾病中的应用范围
...样方法亦可测定肾小球中沉积的免疫复合物内的IgG亚类。Noel报道，不同肾炎时肾小球内沉积之IgG亚类有所不同。原发性膜性肾炎之沉积物为Igg1和IgG4，狼疮性肾炎之沉积物为IgG1、IgG2和IgG3。 3．血清中Tamm-Horsfall糖蛋白（THP）...
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EtiologyofDiarrheainYoungChildreninDenmark:aCase-ControlStudy
...rotypes.Curr.Microbiol.3:95-99.Dennehy,P.H.,S.M.Nelson,S.Spangenberger,J.S.Noel,S.S.Monroe,andR.I.Glass.2001.Aprospectivecase-controlstudyoftheroleofastrovirusinacutediarrheaamonghospitalizedyoungchildren.J.Infect.Dis.184:10-15.deWit,M.A.,M.P.Koopmans,L.M.Kortbeek,W.J.Wannet,J.Vinje,F.vanLeusden,A.I...