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Ratioofoleictopalmiticacidisadietarydeterminantofthrombogenicandfibrinolyticfactorsduringthepostprandialstateinmen
...heratioofoleictopalmiticacid[andthatofmonounsaturatedtosaturatedfattyacids(MUFA:SFA)]inthedietaffectspostprandialconcentrationsoftriacylglycerols,tissuefactor(TF),fibrinogen,tissue-typeplasminogenactivator(t-PA),andplasminogenactivatorinhibitor1(PAI-1).Design:Westudiedtheeffectsofdietsenrichedinoliv...
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Effectsofdietarymonounsaturatedfattyacidsonlipoproteinconcentrations,compositions,andsubfractiondistributionsandonVLDLapolipoproteinBkinetic
...und:Replacingdietarysaturatedfattyacids(SFAs)withmonounsaturatedfattyacids(MUFAs)lowersLDLcholesterol,buttheunderlyingmechanismsremainunclear.Objective:WeassessedtheeffectsofreplacingdietarySFAswithMUFAsonconcentrationsandsubclassdistributionsofVLDL,intermediate-densitylipoprotein,LDL,andHDLandonVLD...
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ReplytoPMarckmann
...nbeneficialeffectsofaweight-maintenance,high–monounsaturatedfattyacid(MUFA),bloodcholesterol–loweringdietcomparedwithahigh-carbohydrate,low-fatdietonimportantcardiovasculardisease(CVD)riskfactors,notablytriacylglycerol,HDL-cholesterol,andplasmaglucoseandinsulinconcentrations(2,3).Itisclear...
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Postprandialeffectofn–3polyunsaturatedfattyacidsonapolipoproteinB–containinglipoproteinsandvascularreactivityintype2diabetes
...gfatfromhigh–oleicacidsafflowerandcanolaoils(monounsaturatedfattyacid;MUFA),MUFA+3.5g-linolenicacid(ALA;MUFA+ALA)fromhigh-ALAcanolaoil,orMUFA+4.0gbotheicosapentaenoicacid(EPA)anddocosahexaenoicacid(DHA;MUFA+EPA/DHA)fromsardineoil.ApoB,LpB,LpB:C,LpB:E+LpB:C:E,andLpA-II:B:C:D:Eweremeasuredatbasel...
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Flow-MediatedDilatationIsImpairedbyaHigh–SaturatedFatDietbutNotbyaHigh-CarbohydrateDiet
...ndothelialvasodilationcomparedwithhighsaturatedfat(SFA),monounsaturatedfat(MUFA),orpolyunsaturatedfat(PUFA)diets.MethodsandResults—Fortyhealthysubjectswererandomlycrossedoverto4,3-weekisocaloricdietshighinPUFA,MUFA,orSFA,containingatleast25goftherelevantfatoralow-fat,CARB,high–glycemicloaddiet.F...
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Dietarycis-monounsaturatedfattyacidsandmetaboliccontrolintype2diabetes
...bohydrate(CHO)dietsormoderatelyhigh-fat,high–monounsaturatedfattyacid(MUFA)dietsarepreferableforthetreatmentandpreventionofdiabeteshasbeenamatterofdebate.High-fatdietsbasedonMUFA-richoilsorwholefoodshavebeencomparedwithhigh-CHOdietsforeffectsonseveralcardiovascularriskoutcomesindiabeticsubjects...
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Macronutrientintakeandglycemiccontrolinapopulation-basedsampleofAmericanIndianswithdiabetes:theStrongHeartStudy
....05forboth).MenwithHbA1c7%reportedsignificantlyhigherintakesoftotalfat,SFA,MUFA,andTFAbutsignificantlylowerintakesofcarbohydrate(as%ofenergyforall)andfiber(g/1000kcal)thandidthosewithHbA1c7%(P0.05forall).WomenwithHbA1c7%reportedsignificantlylowerintakesofcarbohydratesandsucrosebutasignificantlyhighe...
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ApolipoproteinEgenepromoter–219GTpolymorphismincreasesLDL-cholesterolconcentrationsandsusceptibilitytooxidationinresponsetoadietrichin
...edfattyacid(SFA)-richdiet[38%fat—20%SFAand12%monounsaturatedfattyacid(MUFA)—and47%carbohydrates(CHO)],whichwasfollowedbyaCHO-richdiet(30%fat—10%SFAand12%MUFA—and55%CHO)oraMUFA-richdiet(38%fat—10%SFAand22%MUFA—and47%CHO)inarandomizedcrossoverdesign.Attheendofeachdietaryp...
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Polymorphismexon1variantatthelocusofthescavengerreceptorclassBtypeIgene:influenceonplasmaLDLcholesterolinhealthysubjectsduringthecon
...o)–richdiet(30%fat,10%SFA,55%carbohydrate)oramonounsaturatedfattyacid(MUFA),oliveoil–richdiet(38%fat,22%MUFA)accordingtoarandomizedcrossoverdesign.Attheendofeachdietaryperiod,plasmaconcentrationsoftriacylglycerolandoftotal,LDL,andHDLcholesterolweremeasured.Results:Carriersofthe1/2genotypeh...
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Differencesinglucose-dependentinsulinotrophicpolypeptidehormoneandhepaticlipaseinsubjectsofsouthernandnorthernEurope:implicationsforpostpran
...tcompositionbutdifferentsaturatedfattyacid(SFA)andmonounsaturatedfattyacid(MUFA)contentsonpostprandialGIP,insulin,theratioofincrementaltriacylglyceroltoapolipoproteinB-48(amarkerofchylomicronsize),andtheactivityofpostheparinlipases.Results:FastingandpostprandialGIPconcentrationsandpostheparinhepatic...
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Diet-inducedchangeinfattyacidcompositionofplasmatriacylglycerolsisnotassociatedwithchangeinglucagon-likepeptide1orinsulinsensitivityinpe
...ACTBackground:Polyunsaturatedfattyacids(PUFAs)andmonounsaturatedfattyacids(MUFAs)havebeenshowntopositivelyaffectbloodlipids;however,theircomparativeeffectsoninsulinsensitivityareunclear.Objective:OurobjectivewastoinvestigatewhetherchronicintakeofMUFAsorPUFAsimprovesinsulinsensitivityinpeoplewithtype...
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Effectofhigh-carbohydrateorhigh-cis-monounsaturatedfatdietsonbloodpressure:ameta-analysisofinterventiontrials
...s:High-carbohydratediet•high-cis-monounsaturatedfatdiet•high-cis-MUFAdiet•bloodpressure•meta-analysis•hypertensionINTRODUCTIONAccordingtothemostrecentNationalHealthandNutritionExaminationSurvey,whichwasconductedfrom1999to2000,27%ofadultAmericanshavehypertension[systolicblood...
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MacrophagecholesteroleffluxelicitedbyhumantotalplasmaandbyHDLsubfractionsisnotaffectedbydifferenttypesofdietaryfattyacids
...yunsaturatedFA(PUFA)diets(5,6,10,14,17),similarwithTFAandmonounsaturatedFA(MUFA)diets(11,13,16,18),andhigherwithTFAdietsthanwithMUFAdiets(4,12).TFAdietshavetheinconvenienceofloweringHDLcholesterol(4–8).Therearenoclearexplanationsforthedifferencesfoundinthesestudies,becauseseveralfactorsmayhave...
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健康的生活方式与心血管病预防
...脂肪酸=1：1：1)的基础上，进一步强调了单不饱和脂肪酸(MUFA)对血脂及血糖控制的重要意义[8]。建议在限制饱和脂肪酸的同时，增加MUFA的供热比例。 此外，应保证膳食纤维的摄入。早在20世纪70年代，膳食纤维摄入不足就被...
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高脂食物诱导肥胖的代谢组研究取得新进展
...浆和肝脏中多不饱和脂肪酸与单不饱和脂肪酸比值（PUFA/MUFA）的降低表明引发了宿主的氧化应激反应。本研究结果为肥胖的发生发展机制研究提供了代谢组学数据。这项研究得到了国家自然科学基金委、科技部和中国科学院项目...
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Long-termeffectofvaryingthesourceoramountofdietarycarbohydrateonpostprandialplasmaglucose,insulin,triacylglycerol,andfreefattyacidconcent
...rate,low-GI(low-GI);andlow-carbohydrate,high–monounsaturatedfattyacid(MUFA)dietsfor4mo.Plasmaglucose,insulin,andFFAsweremeasuredfrom0800to1600atbaselineinresponsetohigh-GImeals(60%carbohydrate,GI=61,GL=63)andafter4moinresponsetomealsrepresentativeofthestudydiet.Results:Carbohydrateintake(%ofene...
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急性心肌梗死患者饮食护理的研究现状
...。不饱和脂肪酸分为单不饱和脂肪酸(monounsaturatefattyacid,MUFA)和多不饱和脂肪酸(polyunsatu-ratefattyacid，PUFA)，膳食中的MUFA主要是油酸，茶油、花生油、玉米油、芝麻油中油酸的含量丰富。PUFA在海洋高脂鱼和一些坚果如核桃等食物中...
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Dietaryandplasmalipid,lipoprotein,andapolipoproteinprofilesamongelderlyHispanicsandnon-Hispanicsandtheirassociationwithdiabetes
...ributiontototalenergyintakefromtotalcarbohydrates,totalfat[monounsaturated(MUFA),saturated(SFA),andpolyunsaturated(PUFA)fattyacids],andalcohol.Cholesterol(mg)intakewasalsoevaluated.Aphysicalactivityscorewascalculatedbymultiplyingthetimespentindifferentactivitiesbycorrespondingweightingfactorsthatpar...
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Fattydietsareunhealthy—eventhosebasedonmonounsaturates
...lymarginallyandinsignificantlybetweendiets.Theauthorsconcludedthat“ahigh-MUFA,cholesterol-loweringdietmaybepreferabletoalow-fatdiet“inpreventionofcoronaryheartdisease.Thesameopinionwasexpressedbyotherauthors(2).Wewouldliketowarnpeopleagainstconsideringhigh-fatmonoenedietstobethemosthealthydiets....
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Postprandiallipoproteinmetabolism—pivotorpuzzle?
...prandialeffectsoftestmealswith50goffatdifferinginmonounsaturatedfattyacids(MUFA),then–3fattyacid-linolenicacid(ALA),andthen–3very-long-chainpolyunsaturatedfattyacids(VLCPs)onapolipoprotein-definedlipoproteinsubclassesin15diabeticpatients.Theyfoundthatamealcontaining4gVLCPssignificantlyatte...
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Dietaryfatintakeandriskofcoronaryheartdisease:theStrongHeartStudy
...undnoassociationbetweenSFAsandCHDdeath(7,9,10,14).Monounsaturatedfattyacid(MUFA)intakewasinverselyassociatedwithCHDincidencein2studies(11,15),whereasotherstudiesreportedapositiveassociationbetweenMUFAintakeandCHDincidence(3,4)andCHDdeath(5).AninverseassociationbetweenPUFAintakeandCHDincidence(10,15)...
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Acuteingestionofamealrichinn-3polyunsaturatedfattyacidsresultsinrapidgastricemptyinginhumans
...UFAs(EPAX3000TG;PronovaBiocare,Aaslund,Norway),ormonounsaturatedfattyacids(MUFAs;oliveoil;Tesco,Cheshunt,UnitedKingdom).TheEPAX3000TGfishoilwasdiluted(1:1)withsaffloweroiltoreducetheproportionofSFAsinthen-3PUFAtestmealandtoimprovethepalatabilityofthedietaryfishoil.Onehundredmilligrams[1-13C]octanoic...
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糖尿病专用营养配方粉对糖尿病患者餐后血糖的影响
...反应，且不易有饥饿感［3］。（2）用单不饱和脂肪酸（MUFA）部分替代高碳水化合物,不仅使餐后血糖降低,也降低了对胰岛素的需求量,改善血脂代谢［4］。（3）含有大豆纤维和低聚果糖。果糖的血糖指数低于葡萄糖和麦芽糖糊...
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Effectofdietsenrichedinalmondsoninsulinactionandserumlipidsinadultswithnormalglucosetoleranceortype2diabetes
...hbenefitsofhigh-carbohydratedietscomparedwithdietshighinmonounsaturatedfat(MUFA).Ononehand,manystudieshavesuggestedthathigh-fat,low-carbohydratedietshaveadversemetaboliceffects.High-fatdietshavebeenassociatedwiththeworseningofinsulinsensitivityinmanyclinicalstudiesofnondiabeticpersons(1–4)andin...
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DHA与人体健康
...型。ω-7和ω-9属于单不饱和脂肪酸（mono-unsataratedfattyacid，MUFA），可由人体自行从食物中摄取的饱和脂肪酸（sataratedfattyacid，SFA）中合成，但ω-3和ω-6型的不饱和脂肪酸是人类无法自行合成的，必须从食物中摄取，因此常被称为营...
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PreferentialSphingosine-1-PhosphateEnrichmentandSphingomyelinDepletionAreKeyFeaturesofSmallDenseHDL3Particles
...CE,andTGfattyacidresidues,the%distributionofsaturated(SFA),monounsaturated(MUFA),andpolyunsaturated(PUFA)n-6andn-3fattyacidswasindistinguishablebetweenHDLparticlesubspecies(supplementalFigureII).n-6PUFAspreponderatedinallsubfractions(45%to50%oftotal),withlesserabundanceofSFA(30%to35%),MUFA(12%to15%)...
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Plasmapalmitoleicacidcontentandobesityinchildren
...adiposity,especiallyintheabdominalregion,andplasmamonounsaturatedfattyacid(MUFA)profilesinobesechildren.Design:Acase-controlstudywasperformed.Thestudysubjectswere59obesechildren(Results:MUFAprofilesofobesesubjectsshowedasignificantlyhighercontentof16:1n–7,18:1n–9,and20:1n–9andsignific...
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Effectof6dietaryfattyacidsonthepostprandiallipidprofile,plasmafattyacids,lipoproteinlipase,andcholesterolestertransferactivitiesinhealth
...id•oleicacid•transfattyacids•monounsaturatedfattyacids•MUFA•polyunsaturatedfattyacids•PUFA•saturatedfattyacids•SFAINTRODUCTIONDietaryfattyacidintakescurrentlyrecommendedtohelppreventcardiovasculardisease(CVD)arebasedmainlyonthewell-knowneffectsoffattyacidtypeo...
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Effectsofdietarysaturated,monounsaturated,andn–3fattyacidsonbloodpressureinhealthysubjects
...signedfor3motofollow1of2isoenergeticdiets:1richinmonounsaturatedfattyacids(MUFAdiet)andtheotherrichinsaturatedfattyacids(SFAdiet).Eachgroupwasfurtherrandomlyassignedtoreceivesupplementationwithfishoil(3.6gn–3fattyacids/d)orplacebo.Results:SystolicBP(SBP)anddiastolicBP(DBP)decreasedwiththeMUFAdi...
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Novelsoybeanoilswithdifferentfattyacidprofilesaltercardiovasculardiseaseriskfactorsinmoderatelyhyperlipidemicsubjects
...oftheexperimentalfatsasdeterminedbychemicalanalysis.SFA,saturatedfattyacid;MUFA,monounsaturatedfattyacid;PUFA,polyunsaturatedfattyacid;FA,fattyacid;SO,soybeanoil;LoSFA-SO,low–saturatedfattyacidsoybeanoil;HiOleic-SO,high–oleicacidsoybeanoil;LoALA-SO,low–-linolenicacidsoybeanoil;Hydrog-...