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胆囊结石病致病基因的定位研究
...值(NPL)分别为1.77(P=0.05)和1.92(P=0.04)，参数分析优势对数值(LOD)分别为1.84和2.07。D3S1266位点的LOD值为1.35。D11S902位点传递不平衡检验，P值为0.0027。高发病年龄组D3S1266位点的LOD值由1.35上升到2.71，高甘油三酯组D9S1682位点的LOD值由2.07上...
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腹腔镜卵巢打孔术治疗耐药性多囊卵巢综合征15例分析
...米芬的PCOS患者应用腹腔镜对卵巢进行单极电凝打孔术（LOD），术后出现排卵，并相应的获得妊娠。1资料与方法1.1一般资料选择2002年9月～2006年10月阳江市第三人民医院不孕症门诊治疗的PCOS患者，在月经周期或黄体酮撤退性出血...
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NovelGenomicLociInfluencingPlasmaHomocysteineLevels
...tedusingtheSIMWALK2softwareprogram.22Weconsideredmultipointlogarithmofodds(LOD)scores3.00asstatisticallysignificantevidenceoflinkage,2.00assuggestiveevidence,and1.30astentativeevidenceoflinkage.23ThesemultipointLODscorethresholdscorrespondtogenome-wideprobabilityvaluesof0.0001,0.001,and0.007respecti...
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AtherosclerosisSusceptibilityLociIdentifiedFromaStrainIntercrossofApolipoproteinE-DeficientMiceviaaHigh-DensityGenomeScan
...eEMalgorithmwasusedforintervalmappingwithinther/qtlsoftware,whichcalculatedLODscores(logoftheoddsratio)foreachphenotypeacrossthemousegenomeateverySNPpositionandin2-MbintervalsinregionswheremarkerSNPswerenotpresent.Lesionsizewasanalyzedbeforeandafterlog10transformation,whichnormalizesthedistributiona...
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Neuromedinß:astrongcandidategenelinkingeatingbehaviorsandsusceptibilitytoobesity
...31).ToidentifyregionofpromisinglinkageorQTL,weusedP0.0023orlogarithmofodds(LOD)1.75forbothlinkagemethods.Thislevelrepresents,onaverage,onefalsepositivelinkagesignalpergenomescanof400markers(32).Otherinterestingregions(suggestive)arereportedifP0.01orLOD1.17.Achi-squaredtestwasappliedtoevaluatewhether...
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QuantitativeTraitLocusMappingofGenesThatRegulatePhospholipidTransferActivityinSM/JandNZB/BlNJInbredMice
...inmicefedchow(Pltpq1andPltpq2)werefoundonchromosomes3(34cM,logarithmofodds[LOD]3.5)and10(66cM,LOD4.1);twoadditionalQTLinmicefedatherogenicdiet(Pltpq3andPltpq4)werefoundonchromosomes9(56cM,LOD4.5)and15(34cM,LOD5.0);andoneQTL(Pltiq1)fortheinducibilityofPLTPactivitywasfoundonchromosome4(70cM,LOD3.7).Se...
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TheMexican-AmericanCoronaryArteryDiseaseFamilyStudy
...trongestevidenceoflinkagewasfoundonchromosome2atD2S2944(logarithmoftheodds[LOD]=3.08).Othersuggestivelinkageswerealsofoundonchromosome6atD6S1022toD6S2410(LOD=2.21)andchromosome13atD13S796toD13S895(LOD=1.34).Conclusions—TheseresultsshowthatthereisastronggeneticeffectonCIMTintheseMexicanAmericanCADf...
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药物分析实验数据处理
...B）/加入量A×100％回收率的RSD一般应为2％以内。3.检测限(LOD)是指分析方法能够从背景信号中区分出药物时，所需样品中药物的最低浓度，无需定量测定。LOD是一种限度检验效能指标，它既反映方法与仪器的灵敏度和噪音的大小...
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Sweettastepreferencesarepartlygeneticallydetermined:identificationofatraitlocusonchromosome
...tandsuggestivelinkageonchromosome2p22forsaturatedfatintake[logarithmofodds(LOD)2.62].Ouraimwastodeterminetheproportionofthegeneticfactorscontributingtothesweetnessperceptionofaqueoussolutionsandsweetfoodpreferencesinapopulationrandomlyselectedintermsofsweettastepreference-relatedphenotypes.Ifatraitw...
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EatingbehaviorintheOldOrderAmish:heritabilityanalysisandagenome-widelinkageanalysis
...videnceforlinkageofrestraintscoresto2chromosomalregions,nearmarkersD3S1304[LOD(logofodds)=2.5,P=0.0003]andD6S276(LOD=2.3,P=0.0006).WepreviouslyreportedthatD3S1304islinkedtoalocusinfluencingpercentagebodyfatinthissamepopulation(LOD=1.6),suggestingthatthisbehavioralphenotypemaybesecondarytoobesity.The...
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AQuantitativeTraitLocusonChromosome16qInfluencesVariationinPlasmaHDL-CLevelsinMexicanAmericans
...ingevidenceforaquantitativetraitlocus(QTL),withapeakmultipointlogoftheodds(LOD)=3.73(P=0.000034).Subsequentpenetrancemodel-basedlinkageanalysis,incorporatinggenotypesatthemarkerlocusnearestthemultipointpeak(D16S518)intothesegregationmodel,detectedlinkagewiththepreviouslydetectedmajorlocus(LOD=2.73,P...
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QuantitativeTraitLociAnalysisforPlasmaHDL-CholesterolConcentrationsandAtherosclerosisSusceptibilityBetweenInbredMouseStrainsC57BL/6Jand129S1/
...edbysixloci:Hdlq14andHdlq15onchromosome1(peakscM80andcM104,logarithmofodds[LOD]5.3and9.7,respectively);Hdlq16onchromosome8(cM44,LOD2.6);Hdlq17onchromosome9(cM24,LOD2.9);Hdlq18onchromosome12(cM20,LOD5.9);andHdlq19onchromosome2(cM90),whichinteractedwithHdlq15.Atherosclerosissusceptibilitywasaffectedby...
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AGenomeSearchforGeneticDeterminantsThatInfluencePlasmaFibrinogenLevels
...nerabletodeviationsfrommultivariatenormality,givinginflatedlogarithmofodds(LOD)scoresifthedistributionofthetraitpresentshighlevelsofkurtosis.29However,levelsoffibrinogenintheGAITindividualsexhibitedakurtosisof0.42,whichdoesnotaffectthedistributionofLODscores.Thus,thestandardnominalPvaluesforLODscore...
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QuantitativeTraitLocusMappingofGeneticModifiersofMetabolicSyndromeandAtherosclerosisinLow-DensityLipoproteinReceptor-DeficientMice
...smainsulinconcentrationsweredetectedonchromosomes1(females;logarithmofodds[LOD]=2.9)and13(femalesandmales;LOD=4.3).BodyweightQTLswerefoundonchromosomes8(males;LOD=3.4)and13(males;LOD=2.9).Anatherosclerosislocuswasdetectedonchromosome2(femalesandmales;LOD=3.9),and2QTLsinfluencingHDL-Clevelsweredetect...
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一个原发性痛风家系致病易感基因染色体定位
...的染色体区段。结果发现在微卫星引物D4S1572处获得最大LOD值（θ=0．00时LOD=1．50），表明该痛风家系的致病基因与该位点连锁。由此，研究者得出结论，由于D4S1572位于4q25，因此该家系致病基因位于4q25附近。作者：
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一个精神分裂症多发家系染色体候选区域的连锁分析
...在染色体11q23.2-24.2区域获得3个连续高的多点非参数分析LOD值，在D11s925处获得的峰值为4.33(P=0.016)，超过显著性连锁的阈值。与D11s925相邻的D11s898及D11s4151在多点非参数分析中的LOD值分别为1.57和3.82。对¨号染色体上的6个微卫星标志...
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银屑病遗传与基因研究进展
...以引起银屑病发病，说明还存在其他的致病基因，而且用lod积分分析或用同胞配对法进行的家系基础上连锁研究并没有提供确切的证据来支持在HLA位点上或附近存在一个主要的银屑病致病基因。对银屑病高遗传性的研究表明易感...
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Mapping,GeneticIsolation,andCharacterizationofGeneticLociThatDetermineResistancetoAtherosclerosisinC3HMice
...ionQTLs,thepresentcross,onachowdiet,revealedasinglemajorlocusonchromosome9(lod=5.0,Ath29*),andasuggestivelocusonchromosome4(lod=2.6,Ath8).QTLsforplasmaHDL,totalcholesterol,andtriglyceridelevelswerefoundonchromosome1overtheApoA2gene.NeitherofthelesionQTLswereassociatedwithdifferencesinplasmalipidleve...
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体内药物分析方法的设计与评价
...出有关化合物的最小量”。常用最低检测限(Limitofdetection,LOD)或最低检测量(Limitofquantification;LOQ)来表示。LOD范围在ng(10-9g)～10-18g。⑷专属性或选择性(SpecificityorSelectivity)：是指测定的信号（响应）是属于被测药物所特有的。若有干...
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哮喘与ADAM33基因的关系研究新进展
...两个峰值，一个是靠近标记位点D20S906，优势对数评分（LOD）为2.94,另一个是标记位点D20S482(12.1cM区域)，优势对数评分（LOD）也为2.94。而D20S482与哮喘及气道高反应性(bronchialhyper-responsiveness,BHR)相关的LOD值增加为3.93，说明20p13存在...
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加强人体器官捐献规范化管理，提高全民器官捐献意识*
...的方法主要包括增加脑死亡器官捐献(DBD)、活体器官捐献(LOD)、心脏死亡器官捐献(DCD)等，其中增加器官捐献是主要途径。然而在我国，目前各种类型的器官捐献面临诸多现实困难。 2.1DBD现状 2009年卫生部制订了《脑死亡...
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推拿与电针结合治疗面神经麻痹40例临床观察
...用疏密波，分别接阳白与太阳、牵正与地仓。每次30min，lOd为1个疗程。 1.2.2推拿治疗取穴：患侧阳白、四白、睛明、攒竹、地仓、下关、太阳、水沟、承浆、翳风、迎香、颧髎，双侧合谷及额肌、眼轮匝肌、颊肌、咀嚼肌。...
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GenomewideScreenforPulmonaryFunctionin200FamiliesAscertainedforAsthma
...ceforlinkageofpre-andpostbronchodilatorFEV1%VCwasobtainedforchromosome2q32(LOD,4.9,increasingto6.03withadditionalfine-mappingmarkers,and3.2,respectively).Linkageexistedforchromosome5qforpre-andpostbronchodilatorVC(likelihoodofdisease[LOD],1.8and2.6,respectively).Resultsforpre-andpostbronchodilatorFE...
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Quantitativetraitlocusdeterminingdietarymacronutrientintakesislocatedonhumanchromosome2p
...aturatedfatintakewasfoundonchromosome2p22nearmarkerD2S1346[logarithmofodds(LOD)=2.62].Intakesoftotalcalories,fat,protein,andmonounsaturatedfatwerealsosuggestivelylinkedtothesamemarker.Asignificantlinkagesignalonchromosome2p22forleptinconcentrationsandfatmasswaslocalizedinthispopulation,soweusedlepti...
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中西医结合治疗慢性支气管炎急性发作期的疗效观察
...质。对照组仅给予头孢他定，静脉滴注，每日l次，连续lod；观察组在此基础上给予痰热清注射液20ml加入5％葡萄糖注射液250ml，静脉滴注，每日l次，连续lod。1．4观察指标观察并记录用药10d后，观察组和对照组患者临床症状和体...
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ALocusonChromosome2InfluencesLevelsofTissueFactorPathwayInhibitor
...52(P0.0001),withnoevidenceforsharedhouseholdeffects.Inthegenomescreen,only1LODscore2wasobserved.Onchromosome2q,themaximummultipointLODscorewas3.52nearmarkerD2S1384.ThisisnearthestructuralgeneforTFPI,whichislocatedat2q32.Infollow-upassociationanalyses,marginalevidenceofassociation(P=0.04)wasobservedw...
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高效毛细管电泳法分析D苯丙氨酸与DN乙酰苯丙氨酸的对映体杂质含量
...inElmer343,USA）. 自制磺化β环糊精（sulfatedβcyclodextrin，SβCD）由陕西师范大学化学系李保林教授惠赠；其它试剂均为分析纯.对照品：光学纯的D苯丙氨酸、外消旋苯丙氨酸（上海化学试剂二厂）；光学纯的DN...
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顶空固相微萃取气相色谱法测定水中有机氯化合物
...ercialimportpolydimethylsiloxane（PDMS）fiber.ResultsLimitsofdetection（LOD）ofthemethodwerebelow35.3ng/Landrelativestandarddeviations（RSD）werenothigherthan11.8%（n=3）;linearityregressioncoefficients（R）werelessthan0.990;recoveriesrangedfrom71.5to115.5%.ConclusionThesensitivityofsol-ge...
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微液液提取或固相萃取法净化、气相色谱质谱联用检测葡萄酒中19种农药多残留
...在83.3%～116.7%之间（四螨嗪为43%）。SPE法的最低检出限（LOD）0.001～0.01mg/kg之间，定量检出限（LOQ）为0.005～0.05mg/kg，相对标准偏差小于10%；MLLE法为LOD在0.02～0.10mg/kg，LOQ为0.06～0.30mg/kg，相对标准偏差小于14%。所有目标化合物均存...
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遗传流行病学
...色体上相距很远。重组分数越小，两位点相距越近。 lodscore方法假设在已知的遗传模型和某一θ值(0～0.5)下，计算观察家系的似然度(likelihood)与θ=0.5时似然度的比值的对数(lod值)，最大lod值下的θ值是最可能的重组分数值。若l...