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ReplytoJHathcockandIMunro
...afetyofdosesofvitaminDhigherthanthecurrentlowestobservedadverseeffectlevel(LOAEL)waspresentedinpaperspublishedbefore1995,whenthisissuewaslastreviewedbytheFNB.Iknowof2articlesthat,althoughtheydidnotfocusontheissue,clearlyshowedthathighdosesofvitaminDdonotcausehypercalcemiainhealthysubjects(6,7).Neith...
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AssessmentofdietaryvitaminDrequirementsduringpregnancyandlactation
...tantwithrespecttodailyvitaminDintakesisthelowestobservedadverseeffectlevel(LOAEL).Again,thereisalackofevidencetosupportstatementsaboutthetoxicityofmoderatedosesofvitaminD.Forinstance,inthe1989USRDAitisstatedthat5timestheDRIforvitaminDmaybeharmful(5).Thisrecommendationrelatesbacktoa1963expertcommitte...
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EfficacyandsafetyofvitaminD3intakeexceedingthelowestobservedadverseeffectlevel
...Sciencesstatesthat95µgvitaminD/disthelowestobservedadverseeffectlevel(LOAEL).Objective:OurobjectivewastoassesstheefficacyandsafetyofprolongedvitaminD3intakesof25and100µg(1000and4000IU)/d.Efficacywasbasedonthelowestserum25-hydroxyvitaminD[25(OH)D]concentrationachievedbysubjectstakingvitamin...
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RiskassessmentforvitaminD
...tsthatresult.TheNOAELand,ifpossible,thelowest-observed-adverse-effectlevel(LOAEL)areidentified,andthedegreeandtypeofuncertaintyisassignedanumericalvalue,theuncertaintyfactor(UF).3)DerivationoftheUL—asimplearithmeticoperation:UL=NOAEL/UF(orsometimesUL=LOAEL/UF).Thehazardidentificationincludesco...
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VitaminDrequirementsduringlactation:high-dosematernalsupplementationastherapytopreventhypovitaminosisDforboththemotherandthenursinginfant
...cacyandsafetyofvitaminD3intakeexceedingthelowestobservedadverseeffectlevel(LOAEL).AmJClinNutr2001;73:288–94.HeaneyRP,DaviesKM,ChenTC,HolickMF,Barger-LuxMJ.Humanserum25-hydroxycholecalciferolresponsetoextendedoraldosingwithcholecalciferol.AmJClinNutr2003;77:204–10.HollisBW.Individualquantit...
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VitaminsEandCaresafeacrossabroadrangeofintakes
...fanintakethatisano-adverse-effectlevel(NOAEL)oralowest-adverse-effectlevel(LOAEL),evaluationofuncertainty,andcalculationofanintakethatisexpectedtocarrynosignificantriskofadverseeffects,ie,theULoracceptabledailyintake.TheULandacceptabledailyintakemethodsdiffermarkedlyinthewaytheyaddressuncertainty.Th...