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SphingomyelinaseInducesAggregationandFusionofSmallVeryLow–DensityLipoproteinandIntermediate-DensityLipoproteinParticlesandIncreasesTheirReten
...smallverylow–densitylipoprotein(sVLDL)andintermediate-densitylipoprotein(IDL)particlesarealsoabletoenterthearterialintimaandberetainedwithinthesubendothelialextracellularmatrix.Herewecomparedhowproteolysiswith-chymotrypsinandphospholipidhydrolysiswithphospholipaseA2orsphingomyelinase(SMase)ofsVLDL...
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EffectsoftheCholesterylEsterTransferProteinInhibitorTorcetrapibonApolipoproteinB100MetabolisminHumans
...odetermineverylow-densitylipoprotein(VLDL),intermediate-densitylipoprotein(IDL)andLDLapoB100production,andfractionalcatabolicrates(FCRs).Once-daily120mgtorcetrapibsignificantlyreducedVLDL,IDL,andLDLapoB100poolsizesbyenhancingtheFCRofapoB100withineachfraction.Onabackgroundofatorvastatin,120mgtorcetra...
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TRL,IDL,andLDLApolipoproteinB-100andHDLApolipoproteinA-IKineticsasaFunctionofAgeandMenopausalStatus
...ehavioroftriglyceride-richlipoprotein(TRL),intermediate-densitylipoprotein(IDL),andlow-densitylipoprotein(LDL)apoB-100,andhigh-densitylipoprotein(HDL)apoA-I.DatawerefittoamulticompartmentalmodelusingSAAMIItocalculatefractionalcatabolicrate(FCR)andproductionrate(PR).Totalcholesterol,LDLcholesterol(LD...
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第四节 低密度脂蛋白受本基因表达的抑扬
...通过肝脏完成。当用高胆固醇饲料喂养这种动物后，血浆IDL和LDL不被诱导上升，仅仅VLDL的水平轻度升高。 近年来，LDL-R基因剔除的小鼠模型被研制成功。这种LDL-R缺乏的小鼠即使在普通饲料饲养条件下，血浆总胆固醇也高出...
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第二十五章 抗动脉粥样硬化药--第一节 调血脂药
...微粒（CM）、极低密度脂蛋白（VLDL）、中间密度脂蛋白（IDL）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）等。凡血浆中VLDL、IDL、LDL及apoB浓度高出正常为高脂蛋白血症，易致动脉粥样硬化。近年来证明HDL、apoA浓度低于正常，也...
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EffectofEzetimibeontheInVivoKineticsofApoB-48andApoB-100inMenWithPrimaryHypercholesterolemia
...poB-48andvery-low-densitylipoprotein(VLDL),intermediate-densitylipoprotein(IDL),andlow-densitylipoprotein(LDL)apoB-100labeledwithastableisotopewereassessedatbaselineandattheendof8weeksoftreatmentwith10mg/dofezetimibein8menwithmoderateprimaryhypercholesterolemia.Datawerefittoamulticompartmentalmodelu...
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ApolipoproteinB100MetabolisminAutosomal-DominantHypercholesterolemiaRelatedtoMutationsinPCSK9
...ransferrateswereestimatedfromveryLDL(VLDL),intermediate-densitylipoprotein(IDL),andLDLtracerenrichmentsbycompartmentalanalysis.PCSK9mutationdramaticallyincreasedtheproductionrateofapolipoproteinB100(3-fold)comparedwithcontrolsorLDL-Rmutatedsubjects,relatedtodirectoverproductionofVLDL(3-fold),IDL(3-f...
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Randomizedcontrolledtrialoftheeffectofn–3fattyacidsupplementationonthemetabolismofapolipoproteinB-100andchylomicronremnantsinmenwit
...ormatchingplacebo(cornoil,4g/d)for6wk.VLDL,intermediate-densitylipoprotein(IDL),andLDLapoBkineticswereassessedbyfollowingapoBisotopicenrichmentwiththeuseofgaschromatography–massspectrometryafteranintravenousbolusinjectionoftrideuteratedleucine.Chylomicronremnantcatabolismwasmeasuredwiththeuseof...
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第二节 胆固醇酯转移蛋白基因表达的抑扬
...的抑扬 CETP的功能是将HDL颗粒上的胆固醇转移到VLDL和IDL颗粒上，而将VLDL和IDL所含的甘油三酯反向转移到HDL。野生型小鼠缺乏CETP，若将CETP基因转置于小鼠体内增强表达后，小鼠血浆CETP水平可达到人血浆含量，结果导致HDL-C浓...
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血尿酸与血脂关系的分析
...醇（HDL-C）以外的所有脂蛋白中的胆固醇颗粒［（VLDL-C、IDL-C、LP（a）等）］对评价血脂代谢具有重要意义。1资料与方法1.1一般资料2008年2～4月本院男性健康体检者，排除肝、肾、心脑血管疾病，无痛风病史143例。血尿酸浓度＞3...
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EffectsofthePPARagonistpioglitazoneonlipoproteinmetabolisminpatientswithtype2diabetesmellitus
...us(T2DM)affectsanestimated17millionAmericans,anditsincidenceisincreasingrapidlybothintheUnitedStatesandaroundtheworld(1).T2DMisamajorcauseofmorbidityandmortality(2),andatheroscleroticcardiovasculardisease(ASCVD)playsacentralroleinthisseriousproblem.AmongthemanyriskfactorsforASCVDthatareprevalentinT2...
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InterrelationshipsBetweenHumanApolipoproteinA-IandApolipoproteinsB-48andB-100KineticsUsingStableIsotopes
...acdysfunction.Theydidnotsmokeandwerenottakinganymedicationsknowntoaffectlipidlevels.Allfemalesubjectswerepostmenopausal.TheexperimentalprotocolwasapprovedbytheHumanInvestigationReviewCommitteeoftheNewEnglandMedicalCenterandTuftsUniversity.Thesubjectsgaveinformedconsent.ExperimentalProtocolforInVivoS...
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ReplytoDSKalmanandCMColker
...tothecholesterolfromallapolipoproteinB–containinglipoproteins[ie,VLDL,IDL,LDL,andlipoprotein(a)](6).Welabelednon-HDLcholesterolasVLDL+LDLcholesterolbecausethetraditionaldefinitionofLDLentailsLDL+IDL+lipoprotein(a)(7).Wechosetoreportnon-HDLcholesterolbecauseithasbeenshowntobeagoodindicatorofcoro...
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第二节 血脂及其代谢
...外，还有一种中间密度脂蛋白(intermediatedensitylipoprotein，IDL)其密度位于VLDL与LDL之间，这是VLDL代谢的中间产物。HDL在代谢过程中分子中蛋白与脂类成分有变化，可将HDL再分为HDL1、HDL2与HDL3。HDL1是在高胆固醇膳食时才出现，HDL2为成...
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Effectsofdietarymonounsaturatedfattyacidsonlipoproteinconcentrations,compositions,andsubfractiondistributionsandonVLDLapolipoproteinBkinetic
...ctsonthelargerlipoproteinspecies[ie,VLDLandintermediate-densitylipoprotein(IDL)].Small,cholesterol-richVLDLs(VLDL2)arethemajormetabolicprecursorparticlesforLDL,withLDLconcentrationsbeingpositivelyrelatedtotheproductionrateofVLDL2butnotoflarge,triacylglycerolrichVLDL1(10).Wethereforehypothesizedthats...
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甲状腺功能减退症对血脂代谢的影响
...甲状腺功能减退症时HL及HL酶的活性减低可导致VLDL残体向IDL的转变减少，阻止IDL向LDL的转化过程，从而改变LDL和HDL的重构［7］。结果导致血清VLDL残体、IDL、载脂蛋白B、LDL及HDL水平的增高。 本文的研究得以证实，甲状腺功能...
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血清非高密度脂蛋白胆固醇对急性心肌梗死的预测价值
...蛋白，包括极低密度脂蛋白（VLDL）、中间密度脂蛋白（IDL）和HDL，也参与动脉粥样硬化过程［3］。VLDL和IDL均为富含甘油三酯脂蛋白（TGRLP），TGRLP中的富含胆固醇残粒脂蛋白可导致动脉粥样硬化。因此，2001年5月美国国家胆固醇...
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CompleteDeficiencyoftheLow-DensityLipoproteinReceptorIsAssociatedWithIncreasedApolipoproteinB-100Production
...fvery-low-densitylipoprotein1(VLDL1),VLDL2,intermediate-densitylipoprotein(IDL),andLDLapoBwerelowerinFHthanincontrols,withtheLDLapoBFCRbeingsignificantlylower(0.148±0.049versus0.499±0.099pools·d–1;P=0.008).Whereasreceptor-defectiveFHpatientshadatotalapoBPRsimilartocontrols,receptor-nullFHpatien...
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补肾益寿丸对老年高脂蛋白血症400例临床研究报告
...B)普遍增高导致血中CM(乳糜微粒)、VLDL(极低密度脂蛋白)、IDL(中间密度脂蛋白)、LDL(低密度脂蛋白)高于正常而HDL(高密度脂蛋白)、LP(a)脂蛋白(a)、apoA(载脂蛋白A)低于正常滋生动脉硬化、高血压、冠心病、脑卒中等严重危害人民群众...
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-TocopherolModulatesPhosphatidylserineExternalizationinErythrocytes
...),very-low-densitylipoprotein(VLDL),orlow-density(LDL)+intermediatedensity(IDL)lipoproteinsisolatedultracentrifugallyfromaplasmaenrichedwithDL--tocopherol(Calbiochem,SanDiego,Calif)inthepresenceofbutylatedhydroxytoluene(BHT)(2mg/mL).-and-TocopherolQuantitationinIsolatedLipoproteinsandErythrocytesToc...
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低密度脂蛋白胆固醇测定方法研究进展
...血浆分成上下两部分，上清液为VLDL和乳糜颗粒，下面为IDL、LDL和HDL。用试管切开技术将上下液体分开。下面部分再采用化学沉淀法将HDL和LDL及IDL分开，分别用酶法测定胆固醇。这方法已被临床实验室作为参考方法。而且还可以...
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High-DensityLipoproteins:ANewPotentialTherapeuticTargetforthePreventionofCardiovascularDisease
...holesterolinHDLisreturnedtotheliverby2pathways:transferofCEbyCETPtotheVLDL-IDL-LDLlipoproteinswithuptakebytheliverviatheLDLreceptor(LDLr)30andselectiveuptakeofCEbythehepaticSR-BIreceptor.31Inhumans,themajorityofFCistransportedtotheliverbytheHDL-SR-BIpathway,whereasCEistransportedmainlybytheIDL-LDL-L...
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第十四章 抑扬基因表达对脂蛋白代谢及动脉粥样硬化的影响--第一节 载脂蛋白基因表达的抑扬
...足以发挥其作用。 四、ApoB ApoB是乳糜微粒、VLDL、IDL和LDL的运载蛋白，人类肝脏合成的Apob是一个完整的长度，分子量约520000道尔顿，称为ApoB100，而小肠所合成的ApoB由于细胞内mNRA的“编辑加工”处理，其分泌出的ApoB分子...
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n–3Fattyacidsandthemetabolicsyndrome
...rationsinglucoseandlipidmetabolism.Theprevalenceofthemetabolicsyndromeisrapidlyincreasinginrelationtoobesity,anditisconsideredtobeanimportantpredictorofcardiovasculardisease.Increasedintakesorsupplementsofn–3marinefattyacidsmayimprovedefectsininsulinsignalingandpreventalterationsinglucosehomeos...
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EffectsonLipoproteinSubclassesofCombinedExpressionofHumanHepaticLipaseandHumanapoBinTransgenicRabbits
...rolyzingtriglyceridesinchylomicronremnants,intermediatedensitylipoproteins(IDL),andHDL,aswellasphospholipidsinHDL2.2,3Inaddition,itcanalsoenhancecellassociationandremovaloflipoproteinsbyinitiatingtheirbindingtocellsurfaceheparansulfateproteoglycans.4HumanHLdeficiencyisaccompaniedbyincreasesinlarge,b...
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第三节 家族性高脂血症动物模型
...33±13810±1102～3脂蛋白中胆固醇4～56～7VLDL3.3±1.5118±318～9IDL1.3±0.698±2810～12LDL7.0±6.9533±12713～15HDL20.0±4.06±119～2416～18 LDL受体由DNA基因转录为mRNA到合成蛋白质，必须在高尔基体结合糖链转变成成熟的受体被运至细胞表面。在W...
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AssociationsAmongPlasmaLipoproteinSubfractionsasCharacterizedbyAnalyticalCapillaryIsotachophoresis,ApolipoproteinEPhenotype,AlzheimerDisease,a
...ion(peak4),averylowdensitylipoprotein(VLDL)/intermediatedensitylipoprotein(IDL)fraction(peak5),andtwoLDLfractions(peaks6to7:fast-andslow-migratingLDL).ThethreecITPHDLsubfractions(fHDL,iHDL,andsHDL)correspondedtolipoproteininagarosegelelectrophoresis(Figure).ThefLDLandsLDLcorrespondedto?lipoproteinin...
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肾病综合征时出现高脂血症的原因有哪些？
...极低密度脂蛋白(LVDL)、低密度脂蛋白(LDL)、中密度脂蛋白(IDL)、高密度脂蛋白(HDL)。肾病综合征时发生高脂血症的机理尚不十分清楚，目前认为肾病综合征时，低蛋白血症所致的胶体渗透压降低及(或)尿内丢失一种调节因子而引起...
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超速离心-高效液相色谱测定血清高密度脂蛋白和低密度脂蛋白胆固醇
...分离极低密度脂蛋白（VLDL），制备底部组分（BF）(包括IDL,LDL,HDL和Lp(a)等）用肝素-锰离子试剂沉淀BF中的?脂蛋白，制备HDL组分分别用AK胆固醇参考方法测定BF胆固醇(BFC)和HDLC，自BFC中减去HDLC得LDL-C(包括IDL和Lp(a))样品量大(5mL)，其...
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仪器分析品质有关的概念
...常以含基质样品为之，执行前先了解使用仪器的侦测极限IDL.MDL:methoddetectionlimit：使用通过整个处理分析过程的样品来测得。9.仪器侦测极限IDL：仪器讯号为咋讯的2.5~5.0倍时，或在检量线范围中明显的感度转折点。instrumentdetectionl...