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输血相关人类嗜T淋巴细胞病毒感染
1流行病学人类嗜T淋巴细胞病毒Ⅰ型和Ⅱ型(HTLV-Ⅰ/Ⅱ)是上世纪70年代末和80年代初首先发现的感染人类的逆转录病毒,由细胞介导传播。HTLV-Ⅰ在体内主要感染CD4+T淋巴细胞。母乳、精液、血液中存在CD4+T淋巴细胞,所以HTLV-Ⅰ...
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海南省无偿献血人群HTLV-Ⅰ/Ⅱ血清抗体阳性率调查
【摘要】目的了解海南省无偿献血者血清中抗-HTLV-Ⅰ/Ⅱ阳性率。方法用ELISA法筛查献血者血清抗-HTLV-Ⅰ/Ⅱ,初筛阳性者经ELISA法双孔复检,复检呈阳性的标本再用蛋白印迹试验(WesternBlot)进行确认。结果11000名海南省无偿献血...
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中国东北地区HTLV-1的前病毒DNA测定及其意义
摘要:目的了解我国东北的HTLV-1的流行情况及病毒特征。方法从2002年起在东北地区共采取了941份标本,用免疫荧光法进行了血清抗体的检测,经PCR扩增及Southern杂交鉴定。结果发现3例HTLV-1阳性感染病人,阳性率0.3%,没有发现HTLV-2...
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人类T淋巴细胞病毒Ⅰ及Ⅱ型感染的检测
...的工作提出宝贵的意见和建议。 人类T淋巴细胞病毒(HTLV)-Ⅰ与成人T淋巴细胞白血病(ATL)感染有关,HTLV-Ⅱ和T细胞性毛细胞白血病(THCL)感染有关。在世界许多地区均有HTLV-Ⅰ或(和)Ⅱ感染,并在某些地区流行的报道,流行...
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6-2-11RNA肿瘤病毒与人类T细胞白血病
...它们分离到人类T细胞白血病病毒(humanT-cellleukemiavirus,HTLV)。这种病毒在电镜下呈C型病毒颗粒形态,有芽生现象,浮力密度为1.16g/ml,含有高分子量的RNA和逆转录酶,表明其属于RNA肿瘤病毒。 1977年日本学者Uchiyama等报道...
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ProvirusLoadIsLowerinHumanTLymphotropicVirus(HTLV)IICarriersthaninHTLV-ICarriers:AKeyDifferenceinViralPathogenesis
...NationalCancerInstituteFrederick,Frederick,MarylandHumanTlymphotropicvirus(HTLV)IandHTLV-IIarecloselyrelatedretroviruses[1].InadditiontoHTLV-Iassociatedmyelopathy(HAM),HTLV-IisassociatedwithadultTcellleukemia(ATL).SomeevidencesuggeststhatHTLV-IImaybeassociatedwithaHAM-likeneuropathy[2],buttheinciden...
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HumanTLymphotropicVirusTypeI(HTLV-I)ProviralLoadinCerebrospinalFluid:ANewCriterionfortheDiagnosisofHTLV-IAssociatedMyelopathy/TropicalSpa
...talierUniversitairedeFort-de-France,MartiniqueHumanTlymphotropicvirustypeI(HTLV-I)associatedmyelopathy/tropicalspasticparaparesis(HAM/TSP)isassociatedwithaccumulationofHTLV-IinfectedTcellsinthecentralnervoussystem(CNS).However,dataonHTLV-IproviralloadintheCNSattheasymptomaticstagearestilllacking.Wem...
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HelminthicInfectionDown-RegulatesType1ImmuneResponsesinHumanTCellLymphotropicVirusType1(HTLV-1)CarriersandIsMorePrevalentinHTLV-1Carrie
...tionalInstitutesofHealth,Bethesda,MarylandHumanTcelllymphotropicvirustype1(HTLV-1)infectionisassociatedwithanexacerbatedtype1immuneresponseandsecretionofhighlevelsofproinflammatorycytokines.Incontrast,helminthicinfectioninducesatype2immuneresponse.Inthepresentstudy,thecytokineprofileinHTLV-1carriers...
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AProspectiveStudyofSexualTransmissionofHumanTLymphotropicVirus(HTLV)IandHTLV-II
...d.Cross-sectionalstudiessupportsexualtransmissionofhumanTlymphotropicvirus(HTLV)I/II;however,prospectiveincidencedata,particularlyforHTLV-II,arelimited.Methods.Acohortof85HTLV-positive(30withHTLV-Iand55withHTLV-II)blooddonorsandtheirstable(6months)heterosexualsexpartnerswerefollowedbiannuallyoverthe...
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白血病病毒研究的重大发现
...了一种叫做HBZ的蛋白质。HBZ由人类I型T细胞白血病病毒(HTLV-1)制造(HTLV-1是一种反转录病毒,是HIV的远房亲戚)。这项研究表明HBZ能够提升HTLV-1病毒在动物寄主中产生一种持续性感染的能力。美国俄亥俄州立大学综合中心和兽...
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HTLV-1propelsuntransformedCD4+lymphocytesintothecellcyclewhileprotectingCD8+cellsfromdeath
...titutesofHealth,Bethesda,Maryland,USA.AbstractHumanTcellleukemiavirustype1(HTLV-1)infectsbothCD4+andCD8+lymphocytes,yetitinducesadultTcellleukemia/lymphoma(ATLL)thatisregularlyoftheCD4+phenotype.HereweshowthatinvivoinfectedCD4+andCD8+Tcellsdisplayedsimilarpatternsofclonalexpansionincarrierswithoutma...
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Ataxonluxury:HTLV-IinfectionofCD4+CD25+Tregs
...nrevisitedbyYamanoetal.,whodemonstratethathumanTcelllymphotropicvirustypeI(HTLV-I)infectionofCD4+CD25+TregsinpatientswithHTLV-I–associatedmyelopathy/tropicalspasticparaparesis(HAM/TSP)resultsinadecreaseinFOXP3mRNAandproteinexpression.ThisleadstotheinabilityofHTLV-I–infectedCD4+CD25+Tregstoinhibi...
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AdultTcellleukemia:ataleoftwoTcells
...niaMedicalSchool,Norfolk,Virginia,USA.AbstractHumanTcellleukemiavirustype1(HTLV-1)istheetiologicagentforthedevelopmentofanaggressivehematologicneoplasiatermedadultTcellleukemia/lymphoma(ATLL).AlthoughthevirusinfectsTcellsubsetsthatdisplayeitherCD4orCD8cellsurfacemarkers,theleukemiccellisexclusivelyo...
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中国人皮肤型成人T细胞白血病/淋巴瘤一例报道
...酶链反应分别检测患者外周血中嗜人T淋巴细胞病毒Ⅰ型(HTLV-Ⅰ)抗体和淋巴样细胞的HTLV-Ⅰ前病毒DNA。结果此例患者的皮肤损害多形,除表现丘疹、斑块外,并发生疱壁紧张或松弛的大疱。组织病理检查示表皮下水疱,疱底真皮...
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病毒捕手:寻找下一个HIV
...尔夫博士的“嫌疑犯”名单上已经列出了一批新的病毒:HTLV-3、HTLV-4、猴泡沫病毒……它们与HIV同属于逆转录病毒,正蠢蠢欲动地往人类身上迁徙。逆转录病毒的危险之处在于,它能把该病毒的基因物质注入被感染细胞的DNA,所...
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ReplytoHisadaetal.
...ohortsandfoundthatproviralloadwasupto1log10higherinhumanTlymphotropicvirus(HTLV)IcarriersthaninHTLV-IIcarriers.Replicationofthisfindingstrengthenstheconclusionthatthemagnitudeofproviralloadmayexplainthedifferencesinpathogenesisbetweenthe2retrovirusesdifferencesthatexistdespitethesimilargeneticsequen...
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HumanTLymphotropicVirusTypeIIInfectionandHumoralResponsestoPneumococcalPolysaccharideandTetanusToxoidVaccines
...niversityofMinnesota,MinneapolisInfectionwithhumanTlymphotropicvirustypeII(HTLV-II)hasbeenlinkedtoanincreasedincidenceofbacterialpneumonia.TodeterminewhetherHTLV-IIinfectionisassociatedwithimpairedhumoralimmuneresponses,weimmunizedacohortofHTLV-IIinfectedsubjectsandmatcheduninfectedcontrolsubjectswi...
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科学家在非洲发现新的逆转录病毒
...人员已将这两种病毒命名为人类淋巴T细胞病毒3型和4型(HTLV-3、HTLV-4)。目前,他们还不知道这两种病毒对人类危害究竟有多大,但早先发现的其他类型人类淋巴T细胞病毒能引起严重的免疫系统疾病。因此,他们认为这两种...
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Virus-induceddysfunctionofCD4+CD25+TcellsinpatientswithHTLV-I–associatedneuroimmunologicaldisease
...TcellpopulationinpatientswithhumanTcelllymphotropicvirustypeI–associated(HTLV-I–associated)myelopathy/tropicalspasticparaparesis(HAM/TSP)hasbeenshowntobeamajorreservoirforthisvirus,itwasofinteresttodeterminewhetherthefrequencyandfunctionofCD4+CD25+TregsinHAM/TSPpatientsmightbeaffected.Inthesecel...
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TheClonalExpansionofHumanTLymphotropicVirusType1InfectedTCells:AComparisonbetweenSeroconvertersandLong-TermCarriers
...erCenter,BostonBackground.TheclonalexpansionofhumanTlymphotropicvirustype1(HTLV-1)infectedTcellsisconsideredtobeimportantforthemaintenanceofinfection.However,theprocessbywhichtheclonalityofHTLV-1infectedTcellsisestablishedisnotunderstood.Methods.HTLV-1clonalityin4adultseroconverterswasanalyzedbyinve...
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RoleofNeuronalInterferon-intheDevelopmentofMyelopathyinRatsInfectedwithHumanT-CellLeukemiaVirusType
【摘要】HumanT-cellleukemiavirustype1(HTLV-1)isthecausativeagentofnotonlyadultT-cellleukemiabutalsoHTLV-1-associatedmyelopathy/tropicalspasticparaparesis(HAM/TSP).AmongtheratstrainsinfectedwithHTLV-1,chronicprogressivemyelopathy,namedHAMratdisease,occursexclusivelyinWKAHrats.Inthepresentstudy,we...
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AIDS相关病毒与非白血性白血病及Raf信号传导的关系
...多病毒与AIDS的关系并不大,例如:人T细胞白血病病毒1(HTLV-1),,乙型肝炎病毒(HBV),丙型肝炎病毒(HCV)和人疱疹病毒(HHV-6)。在这些病毒中,HTLV-1与非白血性白血病有着在病因学上的联系。近期的观察发现EBV,HBV,HCV和KSHV可能与某...
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医学微生物学-反转录病毒复习题
...制需依赖RNA的RNA多聚酶3.含有反转录酶和整合酶的病毒A.HTLVB.HAVC.登革热病毒D.HHVE.EBV4.除哪项外,下列病毒都能通过性接触传播A.HIVB.HCVC.HSV-2D.HPVE.HTLV5.HIV侵犯的主要细胞是:A.T细胞B.CD8细胞C.CD4细胞D.B细胞E.T细胞和B细胞6.HIV的...
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类风湿关节炎的主要病因探讨
...毒后,在神经异常出现的同时,可引起四肢关节炎。成人HTLV-1可引起HTLV-1伴随的关节炎。把HTLV-1基因转染给小鼠,则该小鼠就会出现慢性增殖性滑膜炎。这进一步说明病毒与关节炎发病有关。1.2与细菌的关系细菌感染可引起无菌...
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去白细胞输血的临床应用进展
...体,如巨细胞病毒(MCV)、人类T淋巴细胞白血病病毒(HTLV-Ⅰ/Ⅱ)和人类免疫缺陷病毒(HIV)等,输血可能导致这些病毒经血传播及潜伏病毒的激活。通过各种物理、化学方法去除血液成分中的白细胞,在防止输血不良反应及...
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我国研制出白血病病毒诊断试剂
...专家鉴定认为,该试剂是“人类T淋巴细胞白血病病毒(HTLV)重组抗原及抗体诊断试剂盒的研制”项目研究取得的重要成果,也是中国自主研究出的第一个HTLV(白血病)筛查试剂,不仅填补了国内空白,也达到国际领先水平。该...
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第十七章 免疫缺陷
...。麻疹病毒和人类亲淋巴细胞病毒(humanTlymphotropicvirus-1,HTLV-1)感染CD4+细胞。HIV和HTLV-1使TH细胞恶变为成熟T细胞白血病/淋巴瘤。结核杆菌和许多真菌的慢性感染常导致免疫缺陷。寄生虫感染如非洲慢性疟疾感染儿童其T细胞功能...
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6-2-8RNA肿瘤病毒与动物白血病
...机理尚未搞清。应该指出,BLV与人类T细胞白血病病毒(HTLV)之间在某些方面相似,如两者的逆转录酶的活性均需Mg2+参与;最初的HTLV是从人类皮肤型淋巴瘤或皮肤型白血病细胞分离的,而BLV注射绵羊能诱发产生皮肤型白血病或...
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淋巴瘤
...淋巴瘤有关,即EB病毒和人类T细胞淋巴瘤/白血病病毒(HTLV-1)。EB病毒已发现与非洲儿童的Burkitt淋巴瘤有密切的病因关系,EB病毒DNA已从Burkitt淋巴镏的细胞核中提取出来。但发生于非洲以外地区的同类型淋巴瘤则未发现与EB...
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第五届全国血细胞诊断学术会议纪要
...科大学报道9例成人T细胞白血病/淋巴瘤(ATL),其中7例患者HTLV-1抗体阳性,表明HTLV-1亦是我国ATL的病因。本病治疗效果及预后均差。山东德州市人民医院和中国医学科学院血液学研究所报道10例慢性粒-单核细胞白血病(CMML),认为CMML是...