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单体素氢质子磁共振波谱研究口腔颌面部恶性肿瘤
...学空间（MEDcyber.com）5月18日消息，单体素氢质子磁共振(1HMR)波谱能为口腔颌面部软组织恶性肿瘤的诊断提供有益信息。口腔颌面部的恶性肿瘤以癌为常见，肉瘤较少。癌肿中绝大多数为鳞状细胞癌，其次为腺性上皮癌，还有基底...
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毛细血管血血糖和静脉血浆血糖相关性分析
...整群抽样与随机抽样相结合的方法，在青岛市6区市抽出3647名常住居民，测定其空腹外周毛细血管血血糖和静脉血浆血糖，应用统计学方法进行数据处理。结果居民的空腹静脉血浆血糖高于外周毛细血管血血糖，差异有显著性（t...
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Conditionalgeneexpressioninrenalcollectingductepithelialcells:useoftheinducibleCre-loxsystem
...enhancedgreenfluorescentprotein(eGFP)-taggedhumanmineralocorticoidreceptor(hMR)inthealdosterone-responsiveRCCD2cellline(8).MATERIALSANDMETHODSCellCultureRCCD2cellswereculturedonpetridishesthathadbeencoatedwithrattypeIcollagen,aspreviouslydescribed(8).Cellswereculturedinadefinedmediumthatcontained1:1...
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TargetedSkinOverexpressionoftheMineralocorticoidReceptorinMiceCausesEpidermalAtrophyPrematureSkinBarrierFormationEyeAbnormalitiesandAlopeci
...MRspecificallytokeratinocytesoftheepidermisandhairfollicle(HF).ExpressionofhMRthroughoutgestationresultedinearlypostnataldeaththatcouldbepreventedbyantagonizingMRsignaling.DTmiceexhibitedprematureepidermalbarrierformationatembryonicday16.5,reducedHFdensityandepidermalatrophy,increasedkeratinocyteapo...
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SolubleGuanylylCyclaseActivationWithHMR1766AttenuatesPlateletActivationinDiabeticRats
...tarrats.After2weeks,treatmentwitheitherplaceboortheguanylylcyclaseactivatorHMR1766(10mg/kgtwicedailybygavage)wasinitiated.Twoweekslater,invivoplateletactivationandinvitroplateletreactivitywereassessed.ChronictreatmentwithHMR1766enhancedNO/cGMP-mediatedsignalinginplateletsfromdiabeticratsdeterminedby...
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深圳公明区职业病危害情况调查
...工总数94069人，其中接触有害因素的16767人。作业岗位数3647家，接触劳动者16767人（男6040人，女10727人）。有害因素主要为有机溶剂（苯系物、正己烷、三氯乙烯等）、粉尘、噪声与铅等，塑料制品业、家具制造业、金属制品业...
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国产格列美脲治疗2型糖尿病的疗效观察
...纪80年代由德国HoechstAG药厂开发成功，1995年被美国FDA批准HMR公司的Amaryl作为2型糖尿病临床用药在美国上市。Amaryl作为进口药物，价格昂贵，国人难以支付。目前国内已出现了国产的格列美脲，并已在临床上应用，但其临床研究...
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ChlamydophilapneumoniaeandMycoplasmapneumoniae
...ayeEN,Collart-DutilleulV,Maridonneau-PariniI,Diu-HercendA.ThenewketolideHMR3647accumulatesintheazurophilgranulesofhumanpolymorphonuclearneutrophils.AntimicrobAgentsChemother1999;43:2457–2462.PhamGiaH,RoederV,NamourF,SultanE,LenfantB.HMR3647achieveshighandsustainedconcentrationsinwhitebloodcellsinm...
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Benefitsandrisksofantiobesityagents
...olicResearchGroup,VeteransAdministrationMedicalCenter,UniversityofKentucky(HMR)WeightManagementProgram,UniversityofKentuckyLexington,KYDearSir:Aftersuccessfulweightloss,long-termweightmaintenanceisdifficultandoftennotsuccessful(1).Whereasrecentstudies(1,2)indicatethatlong-termweightmaintenanceafterv...
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细胞计数与存活测试
...hrosinbluish(SigmaE-9259)及0.05grampreservativemethyl paraben(SigmaH-3647)溶于100mlCa++/Mg++freesaline 2.3.血球计数盘及盖玻片(Hemocytometerandcoverslip) 2.4.计数器(counter) 2.5.低倍倒立显微镜 2.6.粒子计数器(Coultercounter,CoulterElectronics) 3...
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HbeAg阴性乙型肝炎病毒感染机理的研究进展
...8 2.YunCH,etal.JVirol,1992;66:4073 3.ChenIH,et,al.JVirol,1995;69:3647 4.SatoS,etal.AnnalInternalMed.1995;122:241 5.OkamotoH,etal.JVirol,1994;68:8102 6.LaskusT,etal.Gastrocenterology,1995;109:1618 7.MoriyamaK,etal.Virology,1996;226:269 8.ScaglioniPP,etal.Virology,19...
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ProteinKinaseGTransmitstheCardioprotectiveSignalFromCytosoltoMitochondria
...chemicalswerefromSigmaChemicalCo.KT5823,TPP+,andcpt-cGMPwerefromCalbiochem.HMR1098wasagiftofDrHeinrichEnglertofSanofisAventis(Frankfurt,Germany).CyclicGMPproteinkinase1(PKG)waspurifiedfrombovinelung.15PKCisozyme-specificpeptideantagonistsV1-2(EAVSLKPT)16andV1-1(SFNSYELGSL)17weresynthesizedwithapurit...
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缓慢激活延迟整流钾通道（IKs）的研究进展*
...IKs对甲磺酸盐类有抵抗作用，但可被色原烷醇类（293B、HMR-1556）,吲哚帕胺，硫喷妥钠，异丙酚和地西泮（L-768、673，L735、821或L-7）选择性阻断［15～17］。此外，色原烷醇类对于开放通道的阻断作用具有对映选择性，（-）3R，4S-2...
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Effectofacutedietarystandardizationontheurinary,plasma,andsalivarymetabolomicprofilesofhealthyhumans
...t,DivisionofClinicalandMolecularMedicine,TrinityCollege,Dublin,Ireland(MCW,HMR,andMJG),andtheUCDSchoolofBiomolecularandBiomedicalSciences,UCDConwayInstituteofBiomolecularandBiomedicalResearch,UniversityCollegeDublin,Belfield,Dublin,Ireland(LBandJPGM)2SupportedbytheIrishResearchCouncilforScience,Engi...
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不明原因骨痛病人骨显像检查结果分析
...droutinenuclidewholebodyboneimaging.AnanalysiswasdonebycombinationwithMR,CT,andXray.ResultsOfthe247patients,201werepositiveinimaging(81.4%).Thecommoncausesofbonepainaremetastasisofthemalignancy,intervertebraldiscprotrusion,hyperosteosis,andosteoporosis.ConclusionBoneimagingisofgreatervaluei...
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CellularMechanismofCalcium-MediatedTriggeredActivityintheHeart
...hepreparationtoaCCDvideocamera.ExperimentalProtocolIn12wedgesfrom12animals,HMR1556(7eol/L),aselectiveIKschannelblocker,24andIsoproterenol(0.2eol/L),a-adrenergicstimulant,wereadministeredsimultaneouslytoenhancecalciumentry.Thismodelhasbeenshownpreviouslytobeassociatedwithtriggeredactivityinsinglecell...
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10951例育龄妇女生殖健康状况分析
...疗，取得了明显成效。2结果普查结果显示：生殖道感染3647例，发病率为33.3%，占首位。其中各种阴道炎2380例，占21.7%（滴虫性阴道炎、念珠菌性阴道炎、老年性阴道炎、细菌性阴道炎）；慢性宫颈炎976例，占8.9%；慢性盆腔炎及...
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Photorhabdusasymbiotica,aPathogenEmergingonTwoContinentsThatProvesthatThereIsNoSubstituteforaWell-TrainedClinicalMicrobiologist
...ofPhotorhabdusluminescensfrominfectedhumansinAustralia.J.Clin.Microbiol.37:3647-3653.作者：AliceS.Weissfeld,RhondaJ.Halliday,DawnE.Si
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SelectingBcellsandplasmacellstomemory
...rginalzoneBcellsharboringaprediversifiedimmunoglobulinrepertoire.Blood.104:3647–3654.Bernasconi,N.L.,E.Traggiani,andA.Lanzavecchia.2002.MaintenanceofserologicalmemorybypolyclonalactivationofhumanmemoryBcells.Science.298:2199–2202.Hauser,A.E.,G.F.Debes,S.Arce,G.Cassese,A.Hamann,A.Radbruch,andR.A....
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促红细胞生成素对缺血再灌注心脏的心肌保护作用
...4MAP激酶）、白屈菜赤碱（PKC）以及K+通道阻滞剂优降糖、HMR1098，5-HD和Paxilline所阻断；在应用EPO之前（2.3±0.9nmol/min/g）和15min之后（2.4±1.9nmol/min/g）心脏所释放的硝酸盐及亚硝酸盐没有差别；而L-NAME和L-NMA则对EPO的保护作用没有影...
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BrothMicrodilutionandDiskDiffusionTestsforSusceptibilityTestingofPasteurellaSpeciesIsolatedfromHumanClinicalSpecimens
...H.Gerardo,M.Hudspeth,andC.V.Merriam.1998.ActivitiesofHMR3004(RU64004)andHMR3647(RU66647)comparedtothoseoferythromycin,azithromycin,clarithromycin,roxithromycin,andeightotherantimicrobialagentsagainstunusualaerobicandanaerobichumanandanimalbitepathogensisolatedfromskinandsofttissueinfectionsinhumans....
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DodevelopingBcellsneedantigen
...ginalzoneBcellsharboringapre-diversifiedimmunoglobulinrepertoire.Blood.104:3647–3654.Kraus,M.,M.B.Alimzhanov,N.Rajewsky,andK.Rajewsky.2004.SurvivalofrestingmatureBlymphocytesdependsonBCRsignalingviatheIgalpha/betaheterodimer.Cell.117:787–800.Wedemayer,G.J.,P.A.Patten,L.H.Wang,P.G.Schultz,andR.C....
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OntheMechanismofActionof9-O-ArylalkyloximeDerivativesof6-O-Mycaminosyltylonolide,aNewClassof16-MemberedMacrolideAntibiotics
...献】AckermannGandRodloffAC(2003)Drugsofthe21stcentury:telithromycin(HMR3647)-thefirstketolide.JAntimicrobChemother51:497-511.[Abstract/FreeFullText]BerisioR,HarmsJ,SchluenzenF,ZarivachR,HansenHAS,FuciniP,andYonathA(2003)Structuralinsightintotheantibioticactionoftelithromycinagainstresistantmutants...
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提高产后访视质量促进母婴健康（附3922例临床分析）
...534例，中专或高中以上1623例，初中及以下1765例。初产妇3647例，经产妇275例。1.2方法1.2.1组织管理和人员配备城区孕产妇系统管理协作组的产后访视，由本院院后服务中心产后访视组8名医务人员负责，设组长1人。按每10万人口配...
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针对新靶点开发抗肿瘤药物
...试验中显示出良好的抗肿瘤活性。 Flavopiridol(L86-8275，HMR1275)是CDK2和CDK4的双重抑制剂，阻止细胞的G2/M过渡以及细胞从G1期进入S期。Ⅰ、Ⅱ期临床数据显示，Flavopiridol对RCC的反应率良好，肿瘤体积的减小程度高于50%。 UCN-01...
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BreakthroughDisseminatedAspergillusustusInfectioninAllogeneicHematopoieticStemCellTransplantRecipientsReceivingVoriconazoleorCaspofunginProphy
...ceptibilitytestingofCandida[sic]species.Antimicrob.AgentsChemother.46:3644-3647.Gene,J.,A.Azon-Masoliver,J.Guarro,G.DeFebrer,A.Martínez,C.Grau,M.Ortoneda,andF.Ballester.2001.CutaneousinfectioncausedbyAspergillusustus,anemergingopportunisticfungusinimmunosuppressedpatients.J.Clin.Microbiol.39:1134-1...
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DisseminationofSalmonellaentericasubsp.entericaSerovarTyphimuriumvar.CopenhagenClonalTypesthroughaContractHeifer-RaisingOperation
...lmonellaisolatesfromfoodanimalsandgroundmeat.Antimicrob.AgentsChemother.45:3647-3650.作者：NarasimhaV.Hegde,MichelleL.Cook,DavidR.Wol
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脂肪肝危险因素Logistic回归分析
...56名。研究对象一般资料见表1，其中男8309例（69.5%），女3647例（30.5%），按年龄段分成5组，其中20～29岁组2703例（22.6%），30～39岁组4135例（34.6%），40～49岁组2112例（17.7%），50～59岁组1074例（9.0%），60岁以上组1932例（16.2%）。表...
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SmallorganswithahighmetabolicrateexplainlowerrestingenergyexpenditureinAfricanAmericanthaninwhiteadults
...andbrain)—andthereforealowerproportionofbodymassashigh-metabolic-rate(HMR)tissues—thandowhites.Ifthishypothesisprovestobetrue,thenthepreviouslyreportedlowerREEinAfricanAmericansmaybeexplainedtotallyorinpartbydifferencesinthecompositionofthebody’sFFMcompartment.SUBJECTSANDMETHODSSubjec...
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雌激素对脑缺血的神经保护作用机制
...004，5（6）:411-419. 10VogelvangTE，MijatovicV，KenemansP，etal.HMR3339，anovelselectiveestrogenreceptormodulator，reducestotalcholesterol，low-densitylipoproteincholesterol，andhomocysteineinhealthypost-menopausalwomen.FertilSteril，2004，82（6）:1540-1549. 11TomirnotoH，Ak...