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六、粘附分子与凝血
...乏GPIbα、GPIbβ、GPIX三种分子外，同时还缺乏另一条称为GPV的肽链。GPV同样含有LRG序列，其功能还不清楚。GPIb-IX复合物与vWF结合的部位在GPIbα链上，位于其N端的第7个LRG重复序列及近膜部分的富含碳水化合物区域之间（图2-15）。v...
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P-GlycoproteinSubstrateBindingDomainsAreLocatedattheTransmembraneDomain/TransmembraneDomainInterfaces:ACombinedPhotoaffinityLabeling-ProteinHo
...vations).Photolabelingofplasma-membranevesicleswiththeradioactiveanalog[3H]GPV51wasdemonstratedtobehighlyspecificforP-gp,andotherplasmamembraneproteinswerenotlabeledtoanysignificantextent.Inaddition,nonradioactiveGPV51competedwithbindingof[3H]GPV51inaconcentration-dependentmanner(Eckeretal.,2002).Id...
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拜耳亚洲药物警戒：跨国安全报告需求缺失
...家，收集安全数据以及世卫组织的全球疫苗和免疫计划(GPV)的参与情况仍旧不太现实。 问：亚洲如何解决假药事件，标准药物在药品安全和药物警戒上如何才能够使阻力最小化？ JDelumeau：就我个人看，意外不良药物反应...
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SolublePlateletGlycoproteinVIsaMarkerofThrombosisinPatientsWithIschemicStroke
...eischemicstrokestilllackaninformativebiochemicaltest.SolubleglycoproteinV(sGPV)isanewplasmaticmarkerofthrombosisreleasedfromtheplateletsurfacebythrombin.TheobjectiveofthisprospectivestudywastocomparethelevelsofsGPVinstrokeandcontrolpatients.Methods—Consecutivepatientswithacuteischemicstroke(n=159)...
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基于最优效应的左心室的收缩动力学模型及时变主动作用
...为线性的状态方程式:O·a0（t）=-G（RVCaRa+1Ca+1C0）Qa0（t）+GPV（t）CaRa+GU（t）P·（t）=G（R0RVCaRa+R0Ca-RVC0）Qac（t）-GR0/CaRa·PV（t）+GRVU（t）（2）V·（t）=-Qa0（t）P·Va（t）=U（t） 2左心室收缩最优效率 将心脏作为一个血泵看，...
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激光、消疣汤、干扰素α-2b联用对尖减少锐湿疣复发的疗效观察
...病率逐渐增加。目前，国内外不少学者报告有6.11.16.18型GPV与CA关系密切［1］，肛门及外阴CA的患者其HPV亚临床感染相当高［2］，且传播快、易复发，目前尚无确切的单一疗法，我们用中西医结合治疗CA，降低复发率，取得较好的...
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1990～1997年全球控制和消除麻疹进展
...sVaccineInitiative(CVI)andWHO‘sglobalprogrammeforvaccinesandimmunization(GPV)-recommendationsfromtheScientificAdvisoryGroupofExperts(SAGE)［R］.WER,1998,73：281～288.收稿日期：1999－04－12作者：风清扬
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ACrucialRoleofGlycoproteinVIforPlateletRecruitmenttotheInjuredArterialWallInVivo
...ousecarotidarterythatinhibitionorabsenceofthemajorplateletcollagenreceptor,GPVI,abolishesplatelet–vesselwallinteractionsafterendothelialdenudation.Unexpectedly,inhibitionofGPVIbythemonoclonalantibodyJAQ1reducedplatelettetheringtothesubendotheliumby89%.Inaddition,stablearrestandaggregationofplatele...
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ACrucialRoleofGlycoproteinVIforPlateletRecruitmenttotheInjuredArterialWallInVivo
...ousecarotidarterythatinhibitionorabsenceofthemajorplateletcollagenreceptor,GPVI,abolishesplatelet–vesselwallinteractionsafterendothelialdenudation.Unexpectedly,inhibitionofGPVIbythemonoclonalantibodyJAQ1reducedplatelettetheringtothesubendotheliumby89%.Inaddition,stablearrestandaggregationofplatele...
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WHO关于水痘疫苗的意见书
...卫生使用的疫苗应： 1．符合全球疫苗和免疫规划（GPV）对疫苗质量政策声明中规定的质量要求； 2．安全，并对各自目标人群预防实际疾病有明显的效果； 3．若用于婴幼儿，应容易适合国家儿童期免疫计划的免疫程...
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TheFabFragmentofaNovelAnti-GPVIMonoclonalAntibody,OM4,ReducesInVivoThrombosisWithoutBleedingRiskinRats
【摘要】Background-InhibitionofGPVIhasbeenproposedasausefulantithromboticstrategy;however,invivoproof-of-conceptanimalstudiestargetingGPVIarelacking.Weevaluatedanovelanti-humanGPVImonoclonalantibodyOM4Fabinrats.MethodsandResults-OM4Fabspecificallyinhibitedcollagen-inducedaggregationofratplatelet...
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Two-PhaseAntithromboticProtectionAfterAnti-GlycoproteinVITreatmentinMice
...lplateletagonists,actingthroughdifferentreceptors,amongwhichglycoproteinVI(GPVI)andprotease-activatedreceptors,respectively,aretheessentialones.Inmice,targetingofGPVIwiththemonoclonalantibodyJAQ1inducesdepletionofthereceptorfromcirculatingplatelets,resultinginabolishedcollagenresponsesandlong-lastin...
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第一章 白细胞分化抗原--第一节 白细胞分化抗原的分类
...结合vWFCD42c Pt,Meg22，血小板GPIb-β CD42d Pt,Meg85，血小板GPV CD43OTH71C5,G19-1;(Leukosialin)T,G,Mgp95,SialophorinT细胞活化？与CD54结合 续表3CD常用况隆抗体或代号（）主要表达细胞分子量（kDa)和结构功能CD44GRHL1,Hermes,F10-44-2(Pgp-1,ECM-RⅢ)...
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Mindingthegapstopromotethrombusgrowthandstability
...-1(38).LossofPECAM-1expressioninmiceincreasesresponsivenesstocollagenviatheGPVIcollagenreceptor,consistentwithamodelinwhichplateletactivationleadstotyrosinephosphorylationofPECAM-1,allowingSHP-1/2tobindandbringingthephosphatasenearitssubstrates,includingtheFcchainpartnerofGPVI(39,40).Thismaynormally...