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SelectivetargetingofregulatoryTcellswithCD28superagonistsallowseffectivetherapyofexperimentalautoimmuneencephalomyelitis
...animalsafterhigh-orlow-doseCD28superagonisttreatmentshowedclearsuppressionofMBP-specificTconvcells.SuppressionbyCD28superagonist–activatedTregcellswasnotrestrictedtothesurrogateinvitroassay.Uponadoptivetransfer,JJ316/gpMBP-primedCD4+CD25+TregcellsprotectednaiverecipientsfromEAE(Fig.7).Theseactivat...
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SolubleMimicsoftheCytoplasmicFaceoftheHumanV1-VascularVasopressinReceptorBindArrestin2andCalmodulin
...ingprotein(MBP).hV1RintracellularsurfaceelementswereattachedtotheCterminusofMBP.InanattempttocreateamorerealisticmimicofthehV1Rintracellularface,wehavesubsequentlygraftedthethirdintracellularloopofthehV1RaswellitsC-terminalsegmentontothesurfaceofMBPinspatialratherthaninsequentialproximitytoeachother...