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Totaldailyenergyexpenditureamongmiddle-agedmenandwomen:theOPENStudy
...thatdevelopedthe2002DietaryReferenceIntake(DRI)estimatedenergyrequirements(EER)notedthatDLWstudiesinadultsaged40to60ywerelimited.Objective:WeaimedtodescribeTEEandphysicalactivityenergyexpenditureinmiddle-agedmenandwomenbysex,age,menopausalstatus,andlevelofobesity,andtocompareTEEtotheDRIEER.Design:TE...
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Evaluationofformulasforcalculatingtotalenergyrequirementsofpreadolescentchildrenwithcysticfibrosis
...hatmostclosely(within2%)approximatedTER-CFwastheestimatedenergyrequirement(EER)formulaattheactivelevel(EERact).RegressionanalysisofTER-CFontocalculatedTERfromeachformulayieldedthebestindexesofmodelfitfortheEERactformula;residualplotsoftheEERactformulaweretightlyandnormallydistributedaroundzero.Concl...
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原发肿瘤和复发肿瘤的乳癌分子显型不同
...relapsed/metastaticdisease.Inthisstudy,Dr.MacFarlaneandcolleaguescomparedtheER/PRandHER2-receptorstatusofrelapsed/metastaticbreastcancertumorswiththestatusoftheoriginaltumor,usingalargepopulation-baseddatabaseandtissuemicroarray(TMA)cohort.TheresearchersidentifiedwomenfromtheBritishColumbiaCancerAge...
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Energymetabolism,nitrogenbalance,andsubstrateutilizationincriticallyillchildren
...fthiscartinmechanicallyventilatedchildren(7).Theexpectedenergyrequirements(EER)ofhealthychildrenwereobtainedfromTalbot‘stables(18).Ahypermetabolicstatewasdefinedasametabolicindex(REE/EER)1.1(8).Theuseofthistechniqueandclinicalprotocolwasdescribedindetailpreviously(19).Datacollectedincludedage,weig...
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无偿献血者血红蛋白测定结果分析
...献血者；血红蛋白；筛选 Analysisofthehemoglobinassayofvolunteer-donators LUOHai-ling,LIBao-hua,WUWei-jian,etal. FoshanCentralBloodBank,Foshan528000,China 【Abstract】ObjectiveTostudytheapplicationofCuSO4-Densityinthescreeningofvolunteer-donatorshemoglobinlevel.Methods...
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Birthpangs:thestressfuloriginsoflymphocytes
...ractInositol-requiringenzyme1(IRE1)isatransmembraneproteinthatsignalsfromtheERandcontributestothegenerationofanactivesplicedformofthetranscriptionalregulatorX-box–bindingprotein1(XBP1).XBP1isrequiredfortheterminaldifferentiationofBlymphocytesintoplasmacells,andIRE1alsoparticipatesinthisdifferentia...
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Probiotics:futuredirections
...thatsuchpracticesbedirectedbycarefullycontrolledclinicalstudiespublishedinpeer-reviewedjournals.KeyWords:Probiotics•LactobacillusGG•diarrheaINTRODUCTIONJustafewyearsago,thisentiresupplementcouldhavebeenentitledProbiotics:FutureDirections.Inaveryshortperiodoftime,manystudieshavebeenconducte...
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Short-term(intestinal)andlong-term(postintestinal)conversionofß-carotenetoretinolinadultsasassessedbyastable-isotopereferencemethod
...1nmol,or6mg)inoilwasgivenwithaliquiddiet(25%ofenergyfromfat)to22adultvolunteers(10men,12women).Threedaysafterthe[2H8]ß-carotenedose,thevolunteerseachtookadoseof[2H8]retinylacetate(8915nmol,or3mg)inoilwiththesameliquiddiet.Bloodsampleswerecollectedover56d.Results:The53-dareaundertheserum[2H4]ret...
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Asearchfortruthindietaryepidemiology
...epast40y,dietaryepidemiologyhasspawnedthousandsofinvestigationsandmanymorepeer-reviewedpublications.Whyhaveclearanswerssooftenbeendifficulttofind?Bycontrast,nearlyallthelargestudiesofbloodcholesterolorbloodpressureandheartdiseasefindthattheseareimportantriskfactors.Moreover,theepidemiologicresultshe...
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四川凉山杜鹃挥发油成分的同时蒸馏萃取与GCMS分析
...kersonGB.Gaschromatographicevidencefortheoccurrenceofthehopoilcomponentsinbeer.JChromatogr,1996,21(1):18，中国药典.1995.一部：附录ⅩD9，EightPeakIndexofMassSpectra(ThirdEdition1983).PublishedbyMassSpectrometryDataCentre，theRoyalSociatyofChemistry，theUniversityNottinghamNG72RD，UK作...
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XBP-1specificallypromotesIgMsynthesisandsecretion,butisdispensablefordegradationofglycoproteinsinprimaryBcells
...immunoglobulinlightchains.Contrarytoexpectation,degradationofproteinsfromtheER,usingTCRorUS11-mediateddegradationofclassImajorhistocompatibilitycomplexmoleculesassubstrates,isnormalinXBP-1–/–Bcells.Furthermore,degradationofmembraneμwasunaffectedbyenforcedexpressionofXBP-1.Weconcludethatinprimar...
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ModulationofEstrogenSignalingbytheNovelInteractionofHeatShockProtein27,aBiomarkerforAtherosclerosis,andEstrogenReceptor?
...ast2-hybridscreen,weidentifiedpreviouslyunreportedproteininteractionswiththeER?.WeselectedtheA/BdomainofER?asour“bait“becauseitsharesonly30%sequenceidentitywithER.Dual-reportergeneactivity(LEU2and?-galactosidase)identified77positivescreeningresultsfromahumanlungfibroblastcelllinecDNAlibrarythatc...
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Alcoholconsumption,interleukin-6andapolipoproteinEgenotypes,andconcentrationsofinterleukin-6andserumamyloidPinolderadults
...Design:IntheCardiovascularHealthStudy,2454olderadultsreportedtheirintakeofbeer,wine,andliquorandunderwentmeasurementsofcirculatingIL-6andSAP.Results:AlcoholintakewasnotassociatedwithIL-6concentrationsamongapoE4-negativeorIL-6C-positiveparticipantsbutwaspositivelyassociatedamongbothapoE4-positiveandI...
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ElevatedvitaminAintakeandserumretinolinpreadolescentchildrenwithcysticfibrosis1,2,
...hCF,energyintakewasalsoexpressedasthepercentageestimatedenergyrequirement(%EER),aformulaforpredictingenergyrequirementsbasedonage,height,weight,sex,andphysicalactivitylevel(15).ThephysicalactivityofsubjectswithCFwascalculatedastheratiooftotalenergyexpendituremeasuredbythedoublylabeledwatertechnique(...
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Alcoholicbeveragepreference,diet,andhealthhabitsintheUNCAlumniHeartStudy
....Results:Subjectswhopreferredwinehadhealthierdietsthandidthosewhopreferredbeerorspiritsorhadnopreference.Winedrinkersreportedeatingmoreservingsoffruitandvegetablesandfewerservingsofredorfriedmeats.Thedietsofwinedrinkerscontainedlesscholesterol,saturatedfat,andalcoholandmorefiber.Winedrinkerswereless...
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Waistcircumferenceandobesity-associatedriskfactorsamongwhitesinthethirdNationalHealthandNutritionExaminationSurvey:clinicalactionthresholds
...vydrinkersweredefinedasthosewhoeverdrank 5alcoholicbeverages/dordrankbeer,wine,orhardliquoronetimeperdayduringthepastmonth.Moderatedrinkerswerethosewhodrankanalcoholicbeverage(ie,beer,wine,orhardliquor)lessthanonetimeperdayduringthepastmonth.Neverdrinkerswerethosewhodranknobeer,wine,orhardliquo...
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ResilienceoftheDominantHumanFecalMicrobiotauponShort-CourseAntibioticChallenge
...ecosystemtoreturntoitsoriginalprofile—i.e.,itsresilience.Sixhealthyvolunteersreceivedoralamoxicillin(1.5g/day)for5days.Fecalsampleswerecollectedatday0(D0)beforeantibiotictreatmentandatsetintervalsuntil60daysthereafter.FecalDNAwasisolated,andV6-to-V8regionsofthe16SrRNAgeneswereamplifiedbyPCRwithgen...
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ModerateAlcoholConsumptionReducesRiskofIschemicStroke
...adefinedfrequencyresponseset.11,12Inquiriesweremadeaboutconsumptionofwine,beer,andliquorduringthepastyearandonaverageduringeachparticipant’slifetime.Thedefinedresponsesregardingfrequencyallowed9possibilitiesrangingfromneverto6drinksperday.Theresponsesforeachbeveragetypeweresummedtoobtainatotalquan...
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Phosphatidylcholineandlysophosphatidylcholineexcretionisincreasedinchildrenwithcysticfibrosisandisassociatedwithplasmahomocysteine,S-adenosyl
...kChildrenFoundation,Toronto,andbystudentshipsfromtheNaturalSciencesandEngineeringResearchCouncilofCanadaandtheMichaelSmithFoundationforHealthResearch(toAC).3AddressreprintrequeststoSMInnis,BCResearchInstituteforChildren‘sandWomen‘sHealth,DepartmentofPaediatrics,UniversityofBritishColumbia,950Wes...
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IdentificationofaPotentandSelectiveSyntheticAgonistattheCRTH2Receptor
...rculatingeosinophilswereisolatedfromheparinizedvenousbloodfromhealthyvolunteersasdescribedpreviously(Gervaisetal.,2001).Inbrief,erythrocyteswereremovedbyadditionofDextran-T500(AmershamBiosciences),andmononuclearcellswereremovedbymeansofcentrifugationoverFicoll-Paque(AmershamBiosciences).Remainingery...
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Alcoholconsumptioninrelationtoriskofcholecystectomyinwomen
...umptionpatterns(forquantityofalcoholconsumed,P=0.04,0.001,and0.003forwine,beer,andliquor,respectively;forfrequencyofalcoholconsumption,P=0.01,0.07,and0.0001forwine,beer,andliquor,respectively).Conclusions:Theintakeofallalcoholicbeveragetypesisinverselyassociatedwiththeriskofcholecystectomy.Recommend...
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Initialuptakeandabsorptionofnonhemeironandabsorptionofhemeironinhumansareunaffectedbytheadditionofcalciumascheesetoamealwithhighir
...ptakeandthesubsequentserosaltransferandretentionofnonhemeiron.Healthyvolunteersconsumedatestmeallabeledwith59FeCl3and[55Fe]hemeradiotracers.Eachvolunteerparticipatedtwice,atintervalsof4wk,withcheeseaddedto1ofthe2mealsinrandomorder.Eachtime,theentiregutwascleansed8hlaterwithanorallyadministeredlavage...
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ClinicalandPrognosticImportanceofSerotypingMycobacteriumavium-MycobacteriumintracellulareComplexIsolatesinHumanImmunodeficiencyVirus-NegativePa
...matchtheturbidityofano.1McFarlandstandard.TheplateswereinoculatedbyusingaSteer‘sreplicatorwitha1/100dilutionofthesuspensionindistilledwater.Theresultswerereadafter3weeksofincubationat37°C.TheMICwasdefinedasthelowestconcentrationofantibioticwhichcompletelyinhibitedvisiblebacterialgrowth(onecolonyw...
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我国高海拔地区人群微循环研究概况
...为HCT和红细胞聚集指数（RAI）显著增高，红细胞电泳率（EER）和红细胞变形指数（EDI）则明显降低［13～14］。由此说明，高原低氧失血性休克早期红细胞聚集性加强，变形性降低与红细胞免疫功能继发性低下有直接关系。欧湘...
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Nutrientintakeincommunity-dwellingadolescentgirlswithanorexianervosaandinhealthyadolescents
...weight,height,age,andphysicalactivitytocalculateestimatedenergyexpenditure(EER)(20,21).Amodifiableactivityquestionnairewasadministeredtodetermineactivitylevel(22).NutritionalintakeAllparticipantswereinstructedbyaregistereddietitianonthecompletionofa4-dfood(inclusiveofbeverages)recordof3weekdaysand1w...
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HIVProteaseInhibitorsActivatetheUnfoldedProteinResponseinMacrophages:ImplicationforAtherosclerosisandCardiovascularDisease
...ulatorymechanismstocopewiththeaccumulationofunfoldedormisfoldedproteinsintheERandplaysanimportantroleinregulatingcellgrowth,differentiation,andapoptosis(OyadomariandMori,2004;ZhangandKaufman,2004).SeveralUPRcomponentshavebeenidentifiedinmammaliancells,whichincludethreetransducers[ERtransmembranekina...
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LXR-InducedRedistributionofABCG1toPlasmaMembraneinMacrophagesEnhancesCholesterolMassEffluxtoHDL
...massinmediaisrelativetothiscontrol.*P<0.05inaStudentttestforWTvsABCG1-/-.Theerrorbarsforthisandthefollowingexperimentsrepresentstandarddeviation.BandC,Macrophageswerecholesterol-loadedwithacetyl-LDLandtreatedwithTO901317andsiRNAaccordingtotheExperimentalProcedures;160nmolofeitherscrambledorABCG1-tar...
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Altereddiurnalregulationofbloodionizedcalciumandserumparathyroidhormoneconcentrationsduringparenteralnutrition
...)concentrationswerealsoassessed.Resultswerecomparedwiththoseofhealthyvolunteers.Results:Bonemassandboneformationweresubnormalinallpatients.BasalserumPTHconcentrationsweremoderatelyhigherintheTPNrecipientsthaninhealthyvolunteers,andvaluesobtainedevery30minover24hweresignificantlyhigher(P0.001)inTPNre...
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Associationoffolateintakeandserumhomocysteineinelderlypersonsaccordingtovitaminsupplementationandalcoholuse
...oseundergoingchemotherapy.Entrancewasnotlimitedtoanyethnicgroupbutallvolunteerswerewhite;3%wereofHispanicorigin.Morethan40%hadcollegedegrees.Onceacceptedintothestudy,participantswereeligibletocontinueparticipatingregardlessofsubsequentdiagnosisofillnessorprescriptionofmedication.Informedconsentwasob...
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AlcoholdrinkingdeterminestheeffectoftheAPOElocusonLDL-cholesterolconcentrationsinmen:theFraminghamOffspringStudy
...34).Thisquestionnaireincludes136fooditems,withquestionsconcerningintakesofbeer,wine,andspirits.Subjectswereaskedtoreporttheirfrequencyofuseofeachitemperday,week,ormonth.IntakefrequenciesarelinkedwithnutrientdataatHarvardUniversitytoobtainestimatesofdailyintakes(35).Wemeasuredfatintakeinabsolutevalue...