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超级肥胖患者接受十二指肠转位术减肥效果好
...同事在超级肥胖患者中直接比较了应用十二指肠转位术（DS）和Roux-en-Y胃旁路术（RYGB）进行胆胰转道后的体重减轻结果。这是首次针对以上结果进行的大规模单机构研究。科研人员从前瞻性数据库中确定2002年8月至2005年10月间所...
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唐氏综合征产前筛查、诊断预防体系的研究
...综合征产前筛查产前诊断 唐氏综合征（Down‘ssyndrome,DS）又叫先天愚型，是人类最常见的染色体异常引起的疾病，我国从20世纪90年代后期引进西方先进国家常规开展的孕妇血清筛查DS技术，至今不断完善的产前筛查及产前诊...
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生物检定统计法(二)
...──┼─────┼────── 第一次实验 │ds[1] │ds[2] │dT[1] │dT[2] 第二次实验 │dT[2] │dT[1] │ds[2] │ds[1] ───────┴─────┴─────┴─────┴────── 2.平行...
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生物检定统计法(三)
...素效价测定──杯碟法 S为新霉素标准品 稀释液ds[1]∶0.8u/ml ds[2]∶10.0u/ml ds[3]∶12.5u/ml T为新霉素 标示量 ＡT∶670u/mg 稀释液dT[1]∶8.0u/ml dT[2]∶10.0u/ml dT[3]∶12.5u/ml r＝1∶0.8 I＝0.0969 ...
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ExogenousNADPHIncreasesCerebralBloodFlowThroughNADPHOxidase–Dependentand–IndependentMechanisms
...effecthavenotbeenfullyelucidated.WeusedapeptideinhibitorofNADPHoxidase(gp91ds-tat)andnullmicelackingthegp91phoxsubunitofNADPHoxidasetoexaminethemechanismsofthecerebrovasculareffectsofexogenousNADPH.MethodsandResults—Cerebralbloodflow(CBF)wasassessedbylaser-Dopplerflowmetryinanesthetizedmiceequippe...
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系统性自身免疫病患者抗核抗体的分类测定
...女13例，男女之比为1．69∶1。 1．2试剂与检测项目抗ds-DNA及ENA多肽抗体试剂由美国clark实验室提供；ds-DNA为抗IgG和IgM混合物；ENA为抗IgG、IgA和IgM混合物；ENA抗体为抗Sm、抗μ1-RNP、抗SS-A、抗SS-B、抗Scl-70和抗Jo-16项。 1．3同...
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ProtectiveEffectoftheHLA-Bw4I80EpitopeandtheKillerCellImmunoglobulin-LikeReceptor3DS1GeneagainsttheDevelopmentofHepatocellularCarcinomain
...suchvirusesasHCV.WefoundthatthehumanleukocyteantigenBw4I80epitopeandtheKIR3DS1geneweremorefrequentinHCVcarriersthaninpatientswithhepatocellularcarcinoma.Moreover,theseassociationswerenotindependentofeachothertheKIR3DS1/Bw4I80genotypeclearlywasalsomorefrequentinHCVcarriers(oddsratio,24.22).NKcellspro...
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AngiotensinIIAttenuatesEndothelium-DependentResponsesintheCerebralMicrocirculationThroughNox-2-DerivedRadicals
...ationthroughROSgeneratedincerebrovascularcellsbytheenzymeNADPHoxidase.MethodsandResults-Cerebralbloodflow(CBF)wasmonitoredbylaserDopplerflowmetryinanesthetizedmiceequippedwithacranialwindow.AngII(0.25±0.02µg/kgperminutefor30to45minutes)attenuatedtheCBFincreaseproducedbytheendothelium-de...
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Homocysteine,Bvitaminstatus,andcognitivefunctionintheelderly
...lth,UniversityofAberdeen,RoyalCornhillHospital,Aberdeen,UnitedKingdom(LJWandSL);andtheDepartmentofPsychology,UniversityofEdinburgh(IJD).2SupportedbytheUnitedKingdomBiotechnologyandBiologicalSciencesResearchCouncil,theScottishExecutiveEnvironmentandRuralAffairsDepartment,andtheWorldCancerResearchFund...
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系统性红斑狼疮患者血清胆红素检测的临床意义
...试验（ELISA）法测定抗核抗体（ANA）;金标法测定双链DNA（ds-DNA）抗体和免疫印迹法检测多肽抗体（ENA）谱，上述指标用于判定SLE活动期和非活动期。 1.3统计学方法所有数据以x±s表示，组间比较采用配对t检验。 2结果 ...
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双眼单视功能检查和验光配镜
...视角的距离4典型病例例1,患者，女，7岁。原镜：右4.3-1.0DS=4.7,左4.0-4.0DS=5.0。屈光参差3.0D，四孔灯试验无一级功能。调整后:右4.3-1.75DS=5.0，左4.0-3.75DS=5.0。屈光参差2.0D，四孔灯试验二级功能（5m）。点评：此例原镜的验光师不知...
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双眼单视功能检查和验光配镜
...视角的距离4典型病例例1,患者，女，7岁。原镜：右4.3-1.0DS=4.7,左4.0-4.0DS=5.0。屈光参差3.0D，四孔灯试验无一级功能。调整后:右4.3-1.75DS=5.0，左4.0-3.75DS=5.0。屈光参差2.0D，四孔灯试验二级功能（5m）。点评：此例原镜的验光师不知...
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NAD(P)HOxidaseInhibitionAttenuatesNeuronalChronotropicActionsofAngiotensinII
...theAT1receptorantagonistlosartanorbytheselectiveNAD(P)Hoxidaseinhibitorgp91ds-tat.ExtracellularapplicationoftheROSscavenger,Tempol,attenuatedtheAngIIeCinducedincreaseinneuronalfiringrateby70%.Inaddition,gp91ds-tattreatmentresultedina50%inhibitionofAngIIeCinducedincreaseinfiringrate.Incontrast,theROS...
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Naturalselectiondrivesrecurrentformationofactivatingkillercellimmunoglobulin-likereceptorandLy49frominhibitoryhomologues
...ctivatingKIR‘sassociationwithresistancetoinfection,reproductivesuccess,andsusceptibilitytoautoimmunity.Ouranalysissuggestsatwo-stagemodelinwhichactivatingKIRorLy49areinitiallysubjecttopositiveselectionthatrapidlyincreasestheirfrequency,followedbynegativeselectionthatdecreasestheirfrequencyandleads...
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HLA-CandKillerCellImmunoglobulin-likeReceptorGenesinIdiopathicBronchiectasis
...HLA-C/KIRcombinationsbygenotypingpatientswithidiopathicbronchiectasis.Methods:GenomicDNAfrom96individualswithidiopathicbronchiectasisand101controlsubjectswasanalyzedbypolymerasechainreactionwithsequence-specificprimers.High-resolutionHLA-CgenotypingwasperformedinadditiontoKIRanalysis.Results:HLA-Cw0...
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糖尿病导致晶体高指数性屈光不正1例
...以上。1年前开始出现双眼视力下降，在外院验光后配-6.00DS眼镜后能清楚视物。6个月前，戴镜视力又复下降，配-12.00DS眼镜后视力稍有提高，戴镜时无明显不适。全身查体无明显异常。血糖13.6mmol/L。眼科检查，双眼裸眼视力：眼...
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糖尿病导致晶体高指数性屈光不正1例
...以上。1年前开始出现双眼视力下降，在外院验光后配-6.00DS眼镜后能清楚视物。6个月前，戴镜视力又复下降，配-12.00DS眼镜后视力稍有提高，戴镜时无明显不适。全身查体无明显异常。血糖13.6mmol/L。眼科检查，双眼裸眼视力：眼...
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五种自身抗体在狼疮性肾炎患者诊断的意义
...体(ANA)、抗可提取性抗原多肽抗体谱(ENA)、抗双链DNA抗体(dsDNA)、抗中性粒细胞胞浆抗体(ANCA)和抗心磷脂抗体（ACA）在狼疮性肾炎诊断及治疗中的意义。方法采用免疫荧光法测定ANA,蛋白芯片法测定ENA多肽抗体谱,金标法测定抗ds-DNA...
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Diet-inducedchangeinfattyacidcompositionofplasmatriacylglycerolsisnotassociatedwithchangeinglucagon-likepeptide1orinsulinsensitivityinpe
AudreyEBrynes,CMarkEdwards,ArvindJadhav,MohammedAGhatei,StephenRBloomandGarySFrost1FromtheNutritionandDieteticResearchGroup,theEndocrineUnit,andtheLipoproteinTeam,ImperialCollegeSchoolofMedicine,HammersmithHospital,London.2SupportedbyaSmallProjectGrantfromtheBritishDiabetesAssociationandadditionalfu...
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MultilocusSequenceTypingofStreptococcusuberisProvidesSensitiveandEpidemiologicallyRelevantSubtypeInformationandRevealsPositiveSelectioninthe
DepartmentofFoodScienceQualityMilkProductionServices,CornellUniversity,Ithaca,NewYork14853ABSTRACTControlofthebovinemastitispathogenStreptococcusuberisrequiressensitiveandepidemiologicallymeaningfulsubtypingmethodsthatcanprovideinsightintothispathogen‘sepidemiologyandevolution.Developmentofamultil...
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FattyAcidsCauseAlterationsofHumanArterialSmoothMuscleCellProteoglycansThatIncreasetheAffinityforLow-DensityLipoprotein
...ve-Thedyslipidemiaofinsulinresistance,withhighlevelsofalbumin-boundfattyacids,isastrongcardiovasculardiseaserisk.Humanarterialsmoothmusclecell(hASMC)matrixproteoglycans(PGs)contributetotheretentionofapoBlipoproteinsintheintima,apossiblekeystepinatherogenesis.WeinvestigatedtheeffectsofhighNEFAlevelso...
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青蒿挥发性化学成分分析
...国FinniganMAT4610B气相色谱－质谱－计算机联用仪（GC－MS－DS），同时蒸馏－萃取（SDE）装置（图1），Oldshow精馏柱，WMZK－01型恒温控制仪，重蒸乙醚，无水硫酸钠（分析纯），青蒿全株（夏季采收于江苏南部丘陵）。1.2同时蒸馏－...
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Diabetesmellitusandserumcarotenoids:findingsofapopulation-basedstudyinQueensland,Australia
...q.edu.au.ABSTRACTBackground:Epidemiologicevidencesuggeststhatserumcarotenoidsarepotentantioxidantsandmayplayaprotectiveroleinthedevelopmentofchronicdiseasesincludingcancers,cardiovasculardisease,andinflammatorydiseases.Theroleoftheseantioxidantsinthepathogenesisofdiabetesmellitusremainsunclear.Objec...
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新一代药物涂层支架（EXCEL）带给我们的是什么？
...所试验结果QCA结果EXCEL支架（n=32）C型支架（n=28）手术前DS（％）81.1±6.782.6±8.2手术后DS（％）7.11±8.36.2±7.6获得的管腔直径（mm）2.51±0.682.35±0.566个月随访EXCEL支架（n=12/25）C型支架（n=5/11）DS（％）5.98±5.525.21±6.3晚期管腔丢失（m...
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可降解药物洗脱支架能带给我们什么？
...架（n=31）C型支架（n=30）手术前MLD（mm）0.80±0.151.12±0.41DS（％）73.0±16.065.1±12.6手术后MLD（mm）2.92±0.412.82±0.37DS（％）8.5±4.65.4±8.26个月随访Excel支架（n=20/30）C型支架（n=12/18）MLD（mm）2.85±0.372.77±0.46DS（％）11.0±4.710.4±16.5晚期...
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产前筛查在临床上的应用
...键词】产前筛查;唐氏综合征;神经管缺陷 唐氏综合征(DS)也称先天愚型，是母亲生殖细胞形成过程中第21号常染色体由两条变成三条所致，故又称21三体综合征。DS是一种严重的先天性智力障碍性疾病，目前无有效的治疗方法，...
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Transportmechanismsforlong-chainpolyunsaturatedfattyacidsinthehumanplacenta
...leforthepreferentialaccumulationofmaternallong-chainpolyunsaturatedfattyacids(LCPUFAs)inthefetus,weinvestigatedfattyaciduptakeandmetabolisminthehumanplacenta.ApreferenceforLCPUFAsovernonessentialfattyacidshasbeenobservedinisolatedhumanplacentalmembranesaswellasinBeWocells,ahumanplacentalchoriocarcin...
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双侧颜面血管瘤及青光眼的Sturge-Weber综合征一例
...上、下唇增厚呈深紫色。眼部检查：右眼视力0.1（－3.00dS－1.00DC×90°=0.5），左眼视力0.08（-3.50dS-2.00DC×90°=0.3）。双眼球结膜及浅层巩膜可见数条高度扩张、纡曲的血管。双眼前节除瞳孔直径5.5mm、对光反射迟钝外，余未见明显...
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冠心病与免疫
...细胞浸润8hs间质水肿，中性细胞浸入RBC浸入小血管坏死3ds间质水肿，WBC浸入，RBC浸入4d巨噬细胞清除坏死物，淋巴细胞浸入，成纤维细胞浸入10d中性粒细胞，肉芽组织出现，血管生长，成纤维细胞，清除坏死物4w坏死物清除完毕6w...
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综合疗法治疗调节性内斜视伴有弱视的临床分析
...ofaccommodativeesotropiawithamplyopiaandtheeffectofcomplextherapytoit.Methods138casesofaccommodativeesotropiawithamplyopiaweretreatedwithcomplexmethods.Theeffectofthistreatmentwasanalyzed.ResultsThe138casesofesotropiaturnedtoemmetropiawithbinocularsinglevision.Theeffectiveratewas94.74%.ConclusionThe...