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新型糖脂代谢调节因子———共轭亚油酸
共轭亚油酸（Conjugatedlinoleicacid，CLA）是一类含有共轭双键的亚油酸的异构体，由于具有特殊的脂肪链结构，使得其具有多种生理功能。c9t11和t10c12异构体是共轭亚油酸的主要活性异构体。本文对共轭亚油酸的生理功能、代谢、安...
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异构体组成不同的CLA对2型糖尿病小鼠影响
【摘要】目的研究异构体组成不同的CLA对2型糖尿病小鼠血糖、糖耐受性和血液中糖化血红蛋白的影响。方法通过对饲喂高糖高脂饲料建立起来的肥胖型小鼠注射链脲佐菌素，建立2型糖尿病小鼠模型，给模型鼠分别喂食t10，c12-CLA...
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共轭亚油酸对2型糖尿病小鼠血脂的影响
...给其喂食含量分别为90%和80%的游离脂肪酸型共轭亚油酸（CLA-90和CLA-80）和乙酯型共轭亚油酸（CLAEE-80）36天。结果3种共轭亚油酸组合物均能明显降低2型糖尿病小鼠的摄食量、体重、TC、TG和LDL-C（P0.05），同时能显著提高HDL-C（P0.05...
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异构体组成不同的CLA对2型糖尿病小鼠血脂的影响
...菌素，建立2型糖尿病小鼠模型，给模型鼠分别喂食t10,c12-CLA:c9,t11-CLA比例为1.42和2.79的CLA36天，测定小鼠摄食量、体重、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）。结果两种共...
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CLA与胰岛素抵抗的关系研究
CLA与胰岛素抵抗的关系研究(pdf)【摘要】目的通过研究共轭亚油酸CLA对2型糖尿病小鼠肝脏和血清中FFA及TNF-α的作用探讨其与胰岛素抵抗的关系。方法通过对饲喂高糖高脂饲料建立起来的肥胖型小鼠注射链脲佐菌素，建立2型糖尿...
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共轭亚油酸对2型糖尿病小鼠降糖作用的研究
...type2diabetesmellitusHbAlc 共轭亚油酸（conjugatedlinoleicacid，CLA）是人体必需脂肪酸-亚油酸的几何异构体和位置异构体的总称。1978年Pariza［1］等人在研究烤牛肉中的诱变剂时，发现共轭亚油酸具有抗癌特性。此后许多学者对共轭亚...
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Opposingeffectsofcis-9,trans-11andtrans-10,cis-12conjugatedlinoleicacidonbloodlipidsinhealthyhumans
...ertFGrimble,ChristineMWilliams,ParveenYaqoobandPhilipCCalder1FromtheHughSinclairUnitofHumanNutrition,SchoolofFoodBiosciences,UniversityofReading,Reading,UnitedKingdom(ST,SK,ELJ,CMW,andPY),andtheInstituteofHumanNutrition,UniversityofSouthampton,Southampton,UnitedKingdom(GCB,TB,JJR,RFG,andPCC)2Support...
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Analysisofconjugatedlinoleicacidandtrans18:1isomersinsyntheticandanimalproducts
...allyoctadecadienoicacids(18:2;commonlyreferredtoasconjugatedlinoleicacid,orCLA),hasprovidedmanychallengestolipidanalystsbecauseoftheiruniquephysicalpropertiesandthemanypossiblepositionalandgeometricisomers.Aftertheacid-labilepropertiesofCLAsduringanalyticprocedureswereovercome,itbecameevidentthatnat...
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共轭亚油酸的毒理学研究
...Themouseacutetoxicitytestandhereditytoxicitytestofconjugatedlinoleicacid（CLA）wereinvestigated.MethodsItisshownthatalltestsofacuteandhereditytoxicityarenegative.ResultsThestudyofratson30dayfeedingshowsthattheexperimentalgroupshavebeeningoodstate，andthebodyweight，foodintake，haematologicalpro...
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Effectsofcis-9,trans-11andtrans-10,cis-12conjugatedlinoleicacidonimmunecellfunctioninhealthyhumans
...ertFGrimble,ChristineMWilliams,PhilipCCalderandParveenYaqoob1FromtheHughSinclairUnitofHumanNutrition,SchoolofFoodBiosciences,TheUniversityofReading,Reading,UnitedKingdom(ST,SK,CMW,andPY),andtheInstituteofHumanNutrition,UniversityofSouthampton,Southampton,UnitedKingdom(GCB,TB,JJR,RFG,andPCC)2Supporte...
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Effectsofcis-9,trans-11conjugatedlinoleicacidsupplementationoninsulinsensitivity,lipidperoxidation,andproinflammatorymarkersinobesemen
...kground:Werecentlyshowedthattrans-10,cis-12(t10,c12)conjugatedlinoleicacid(CLA)causesinsulinresistanceinobesemen.However,metaboliceffectsofthec9,t11CLAisomerarestillunknowninobesemen.Becausec9,t11CLAisthepredominantCLAisomerinfoodsandisincludedindietaryweight-lossproducts,itisimportanttoconductrando...
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Conjugatedlinoleicacid–enrichedbeefproduction
...icarcinogeniceffectsofbeefextractsduetothepresenceofconjugatedlinoleicacid(CLA)hasheightenedinterestinincreasingtheamountofCLAdepositedinbeef.BeefcattleproduceCLAanddepositthesecompoundsinthemeat;thus,beefconsumerscanreceivebioformedCLA.BeefcontainsbothofthebioactiveCLAisomers,namely,cis-9,trans-11a...
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Perspectiveonthesafetyandeffectivenessofconjugatedlinoleicacid
...heFoodResearchInstituteattheUniversityofWisconsin-Madison.MWPisaninventorofCLA-usepatentsthatareassignedtotheWisconsinAlumniResearchFoundation.4Reprintsnotavailable.AddresscorrespondencetoMWPariza,FoodResearchInstitute,UniversityofWisconsin-Madison,1925WillowDrive,Madison,WI53706.E-mail:mwpariza{at}...
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Conjugatedlinoleicacidsupplementationfor1yreducesbodyfatmassinhealthyoverweighthumans
...scr.no.ABSTRACTBackground:Short-termtrialsshowedthatconjugatedlinoleicacid(CLA)mayreducebodyfatmass(BFM)andincreaseleanbodymass(LBM),butthelong-termeffectofCLAwasnotexamined.Objective:Theobjectiveofthestudywastoascertainthe1-yeffectofCLAonbodycompositionandsafetyinhealthyoverweightadultsconsumingana...
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Metaboliceffectsofconjugatedlinoleicacidinhumans:theSwedishexperience
...MedicalResearchCouncil(27X-13083)andNaturalLipids,Norway,whoalsosuppliedtheCLAsupplements.4AddressreprintrequeststoBVessby,UnitforClinicalNutritionResearch,DepartmentofPublicHealthandCaringSciences,UniversityofUppsala,POBox609,SE-75125Uppsala,Sweden.E-mail:bengt.vessby{at}pubcare.uu.se.ABSTRACTConju...
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Conjugatedlinoleicacids,atherosclerosis,andhepaticvery-low-densitylipoproteinmetabolism
...tia,CanadaB3H1X5.E-mail:rmcleod2{at}dal.ca.ABSTRACTConjugatedlinoleicacids(CLAs)areisomericformsofthe18:2fattyacidthatcontainconjugatedsitesofunsaturation.AlthoughCLAsareminorcomponentsofthediet,theyhavemanyreportedbiologicalactivities.Fornearlyadecade,thepotentialforCLAtomodifytheatheroscleroticpro...
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Conjugatedlinoleicacidsupplementation,insulinsensitivity,andlipoproteinmetabolisminpatientswithtype2diabetesmellitus
...BSTRACTBackground:Someanimalstudieshavesuggestedthatconjugatedlinoleicacid(CLA)supplementationmayhavetherapeuticpotentialwithrespecttoinsulinsensitivityandlipidmetabolism,whichareimportantcardiovasculardisease(CVD)riskfactorsassociatedwithtype2diabetesmellitus.Objective:WeinvestigatedtheeffectofCLAs...
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Conjugatedlinoleicacidreducesparathyroidhormoneinhealthandinpolycystickidneydiseaseinrats
...weiler{at}ms.umanitoba.ca.ABSTRACTBackground:Feedingconjugatedlinoleicacid(CLA)isreportedtoreduceprostaglandinE2synthesis,whichisrequiredforparathyroidhormone(PTH)release.Objective:ThisstudywasundertakentodeterminewhetherCLAwouldsuppresshyperparathyroidismandtheresultinghigh-turnoverbonediseaseinara...
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Dietaryconjugatedlinoleicacidandbodycomposition
...H9X3V9.E-mail:jonesp{at}macdonald.mcgill.ca.ABSTRACTConjugatedlinoleicacid(CLA)isagroupofpositionalandgeometricisomersofconjugateddienoicderivativesoflinoleicacid.ThemajordietarysourceofCLAforhumansisruminantmeats,suchasbeefandlamb,anddairyproducts,suchasmilkandcheese.ThemajorisomerofCLAinnaturalfoo...
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ConjugatedLinoleicAcidImpairsEndothelialFunction
...ves-Todeterminetheeffectofdietarysupplementationwithconjugatedlinoleicacid(CLA)onbodymassindex(BMI),bodyfatdistribution,endothelialfunction,andmarkersofcardiovascularrisk.MethodsandResults-FortyhealthyvolunteerswithBMI27kg/m2wererandomizedtoreceiveaCLAisomericmixtureoroliveoilina12-weekdouble-blinds...
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Dietaryconjugatedlinoleicacidandinsulinsensitivityandresistanceinrodentmodels
...da.E-mail:ctaylor{at}ms.umanitoba.ca.ABSTRACTDietaryconjugatedlinoleicacid(CLA)isbeinginvestigatedforbeneficialeffectsfordiseasepreventionandtreatmentinavarietyofexperimentalmodels,includingobesityandtype2diabetes.Todate,rodentstudiessuggestthattrans-10,cis-12(t10,c12)CLAisassociatedwithgreaterinsul...
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特应性皮炎患者外周血表达不同细胞因子T细胞亚群的检测
...胞因子（包括IL-4、IL-5、IFN-γ、TNF—α的CD4^＋T、CD8^＋T、CLA^＋T细胞亚群的频数。利用特应性皮炎皮损面积严重度指数积分法方法，获取特应性皮炎患者病情严重程度积分，分析其与表达不同细胞因子的T细胞频数的相关性。结果...
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4120例非淋菌性泌尿生殖道炎支原体感染检测分析
...pectively.Drugsensi-tivityresultsshowedthatUU，MHandUU+MHweresusceptibletoclarithromycin，josamycin，doxycylineandminocycline.Con-clusionMycoplasmainfectioningenitourinarytractismainlyduetoUUinfectionandmixedinfectionwithUUandMH.AndMHinfectionaloneisrare.Clinicalselectionofdrugsfortreatmentshould...
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幽门螺杆菌致消化性溃疡的机制及现代治疗
...4］：PPI与两种抗生素组合；抗生素常用的有克拉霉素（CLA）、阿莫西林（AMO）、甲硝唑（MET）、呋喃唑酮（FZ）。刘文忠等［5］采用兰索拉唑30mg，qd;CLA250mg，bid;FZ100mg，bid;疗程1周，Hp根除率达90%以上；LindT等［6］采用奥美拉唑20...
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幽门螺杆菌致消化性溃疡
...I三联[3]：PPI与两种抗生素组合;抗生素常用的有克拉霉素(CLA)、阿莫西林(AMO)、甲硝唑(MET)、呋喃唑酮(FZ)。刘文忠等[4]采用兰索拉唑30mg，qd;CLA250mg，bid;FZ100mg，bid;疗程1周，Hp根除率达90%以上;LindT等[5]采用奥美拉唑20mg，bid;CLA500mg，bi...
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Immunomodulatorypropertiesofconjugatedlinoleicacid
...softheuseofimmunecellsandanimalmodelsdemonstratethatconjugatedlinoleicacid(CLA),alipid,modulatesimmunefunction.Inaddition,recentpublicationsdemonstratethat2activeCLAisomers(ie,cis-9,trans-11CLAandtrans-10,cis-12CLA)modulateimmunefunctioninhumans.Aspectsofboththeinnateandadaptiveimmuneresponsesareaff...
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真皮免疫系统研究进展
...巨噬细胞前体为血液中的幼单核细胞；人类外周血中cD34+CLA+树突状细胞[CD71（low）/CD11a+/CD11b+/CD49d+/CD45RA+]体外经粒细胞-巨噬细胞集落刺激因子和肿瘤坏死因子（tNF）-α诱导可分化为郎格罕细胞，cD34+CLA-树突状细胞[CD71+/CD11a（low）...
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AllelicVariantsoftheHumanScavengerReceptorClassBType1andParaoxonase1onCoronaryHeartDisease
...L)havebeenattributedtoparaoxonase(PON)enzymeactivity.HumanscavengerreceptorclassBtype1(SR-BI;CD36andlysosomalintegralmembraneprotein-IIanalogous-1[CLA-1])playsacentralroleinHDL-mediatednativeandoxidizedcholesterylesteruptake.Wetestedforasignificantcontributionofcommonvariantofthesegenestocoronaryhea...
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Effectofconjugatedlinoleicacidonbodycompositionandplasmalipidsinhumans:anoverviewoftheliterature
...sinmicehaveindicatedthatfeedingdietscontaining0.5-1%conjugatedlinoleicacid(CLA)considerablyreducesbodyfat.ThesefindingshaveattractedmuchinterestbecauseofthepotentialuseofCLAasatooltopromoteweightlossinhumans.SeveralCLAstudiesinhumanshavenowbeenpublished,andtheobjectiveofthepresentreviewwastogiveanov...
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Evidenceforpotentialmechanismsfortheeffectofconjugatedlinoleicacidontumormetabolismandimmunefunction:lessonsfromn–3fattyacids
...6G2P5.E-mail:catherine.field{at}ualberta.ca.ABSTRACTConjugatedlinoleicacid(CLA)andthelong-chainpolyunsaturatedn–3fattyacidshavebeenshowninvivoandinvitrotoreducetumorgrowth.Tumorgrowthcouldoccurbyslowingorstoppingcellreplication(byinterferingwithtransitionthroughthecellcycle),increasingcelldeath...