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椎间盘突出手术的经济效益
...9,403(49,523–94,999)34,355(20,419–52,512)直接医疗72,181(56,473–92,394)37,285(28,364–48,993)间接医疗与生产力77,300(60,009–99,544)42,111(30,976–56,284) 研究者指出，我们经济评估的强处在于我们可以在分析中考量工作相关生...
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FunctionalspecificityofSgk1andAkt1onENaCactivity
...rgetsofphosphoinositide3-kinaselipidproducts.Phosphorylationoftworesidues(S473andT308inAkt1,andS422andT256inSgk1)bythephosphatidylinositol3,4,5-trisphosphate-dependentkinasesPDK1andPDK2determinesactivationofAkt1andSgk1(1,2,16).Thetwokinasesalsooverlapintissuedistributionandinsubstratespecificity.Whe...
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C-ReactiveProtein,FibrinD-Dimer,andRiskofIschemicHeartDisease
...90months)ofthecombinedCaerphilly–Speedwellcohort,comprising4453men,ofwhom473hadmajorIHDevents.MethodsStudyPopulationsTheCaerphillyandSpeedwellpopulation-basedstudiesbeganin1979andhavebeenpreviouslydescribed.6,12TheCaerphillysubjectsofthisreportarethosemenwhowereseenatthefirstre-examinationbetween1...
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SerumLipidProfilesPoorlyCorrelateWithChlamydiapneumoniae,Helicobacterpylori,andCytomegalovirusSeropositivityinProspectivelyFollowed-UpHealthy
...andIgAseropositivityamongJerusalemresidents.EpidemiolInfect.1995;114:465–473.SaikkuP,RuutuP,LeinonenM,PaneliusJ,TupasiTE,GraystonJT.Acutelower-respiratory-tractinfectionassociatedwithchlamydialTWARantibodyinFilipinochildren.JInfectDis.1988;158:1095–1097.MurrayLJ,O’ReillyDP,OngGM,O’NeillC,Eva...
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中药穴位敷贴疗法治疗小儿厌食症的Meta分析*
...赵建梅.小儿厌食症的中医治疗概况.河北中医,2009,33(3):472-473. 2陈金风.推拿治疗小儿厌食82例.江苏中医,2000,21(8):37. 3梁万玲.从肝论治小儿厌食症体会.四川中医,2000,18(11):38. 4史纪,程志,董自巧.厌食膏外敷治疗小儿厌食症2...
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Visceralfatthicknessmeasuredbyultrasonographycanestimatenotonlyvisceralobesitybutalsorisksofcardiovascularandmetabolicdiseases
...FA(r=0.799,P0.001),VSR,andVMR.TheVFT:SFTmaxwaswellcorrelatedwiththeVFA(r=0.473,P0.05),VSR,andVMR.Incontrast,thecorrelationofwaistcircumferencewithVFA(r=0.543,P0.05)wasweakerthanthatwiththeVFT.Viewthistable:TABLE3.Pearson’scorrelationcoefficientsbetweenthevaluesmeasuredbycomputedtomography(CT)an...
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ChronicChlamydiapneumoniaeInfectionandStrokeinCameroon
...andIgAseropositivityamongJerusalemresidents.EpidemiolInfect.1995;114:465–473.NgehJ,GuptaS,GoodbournC,PanayiotouB,McElligottG.Chlamydiapneumoniaeinelderlypatientswithstroke(C-PEPS):acase-controlstudyontheseroprevalenceofChlamydiapneumoniaeinelderlypatientswithacutecerebrovasculardisease.Cerebrovasc...
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CharacteristicsofBloodPressureProfilesasPredictorsofLong-TermOutcomeAfterAcuteIschemicStroke
...acutestrokeisassociatedwithpoorfunctionaloutcome.JInternMed.2001;249:467–473.CarlbergB,AsplundK,HaggE.Theprognosticvalueofadmissionbloodpressureinpatientswithacutestroke.Stroke.1993;24:1372–1375.OhkuboT,ImaiY,TsujiI,NagaiK,ItoS,SatohH,HisamichiS.Referencevaluesfor24-hourambulatorybloodpressuremo...
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AProspective,NestedCase-ReferentStudyofPlasmaConcentrationsandDietaryIntake
...ICD-9codes430to438correspondingtoICD-10codesI60toI69.Ofthe14030strokecases,473(excludingsubarachnoidhemorrhages)haddonateddataand/orsamplestotheNorthernSwedenMedicalBiobankandmettheinclusioncriteriaofnopreviousacutemyocardialinfarctionandnocancerdiagnosiswithinthe5yearsbeforerecruitment;458cases(97%...
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Dietaryintakeoftransfattyacidsandsystemicinflammationinwomen
...calactivity,andthus373NHSparticipantswereincludedinthisanalysis.IntheNHSII,473premenopausalparticipantswererandomlyselected,stratifiedbyalcoholdrinkingpatterns(frequency,amount,withorwithoutmeals),forastudyonalcoholconsumption(27).WomenwereexcludediftheyweretakinghormonesorhadahistoryofMI,angina,str...
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ConsumptionofcoffeeisassociatedwithreducedriskofdeathattributedtoinflammatoryandcardiovasculardiseasesintheIowaWomen‘sHealthStudy
...8.4,38.9,42.9,46.1,54.3,54.7,70.3,70.5,75,78.5,117.5,117.9,137,322.9,323.9,473.9,480.9,481,482,482.1,482.3,482.4,482.8,485,486,487.1,540,555.9,566,567.2,614.4,and682.6andICD-10classificationsA04.4,A04.7,A31.9,A41.9,A49.0,A81.0,B18.2,B44.1,B49,B94.8,G03.9,J11.0,J11.1,J15.2,J15.9,J18.0,J18.1,J18.9,J22...
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InhibitionofRho-KinaseLeadstoRapidActivationofPhosphatidylinositol3-Kinase/ProteinKinaseAktandCardiovascularProtection
...heRho-kinaseinhibitor,hydroxyfasudil(HF)(1to100μmol/L),increasedAktserine-473phosphorylationwithin15minutes,leadingtoa2.2-foldand4.0-foldincreaseinAktkinaseactivityandnitricoxide(NO)release,respectively.ActivationofAktandeNOSbyHFwascompletelyblockedbythephosphatidylinositol3-kinase(PI3-kinase)inhib...
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Influenceofreportingerrorontherelationbetweenbloodfolateconcentrationsandreportedfolicacid–containingdietarysupplementuseamongreproduc
...4nmol/L)andthatamongwomenwhoreportedaveragedailyuseof400µgfolicacidwas473.6nmol/L(95%CI:455.9,491.8nmol/L).Ofwomenwhoreportedaveragedailyuseof400µgfolicacid,theadjustedmeanRBCfolatewas17.8%higherinthosewhoreportedtakingsupplementsintheprevious24hthanitwasamongthosewhoreportednouseofsupplem...
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TandemInternalCarotidArtery/MiddleCerebralArteryOcclusion
...eptibilitysignatecho-planargradient-echoMRimaging.Radiology.2004;232:466–473.BlincA,FrancisCW.Transportprocessesinfibrinolysisandfibrinolytictherapy.ThrombHaemost.1996;76:481–491.RubieraM,Alvarez-SabnJ,RiboM,MontanerJ,SantamarinaE,ArenillasJF,HuertasR,DelgadoP,PurroyF,MolinaCA.Predictorsofearlya...
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DietarypatternsandcardiovascularmortalityintheMelbourneCollaborativeCohortStudy
...fthediabetesvariable.AmongparticipantswithoutabaselinehistoryofCVD(Table4),473CVDdeaths,including242fromIHD,occurredsincebaseline.Inmodel1(withoutdiabetes,WHR,BMI,andhypertension)boththevegetableandfreshfruitfactorswereinverselyassociatedwithCVDmortality.Afterfurtheradjustmentforothercovariates(mode...
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冠状动脉内支架置入术后期死亡原因分析
...649心肌梗死369(49.9)1.271.02-1.580.035高血压545(73.0)1.350.60-2.650.473吸烟史401(53.7)1.250.59-3.060.554血脂异常403(53.9)0.630.32-1.240.180糖尿病157(21.0)2.911.48-5.710.002开口处病变68(9.10)1.930.72-5.150.191多支血管病变367(49.1)1.610.79-3.310.192B2/C型病变477(63.9)0.8...
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TheDifferentialInteractionsofPeroxisomeProliferator-ActivatedReceptorLigandswithTyr473IsaPhysicalBasisforTheirUniqueBiologicalActivities
...studiesdemonstratedthat,unlikerosiglitazone,SPPARM2didnotinteractwiththeTyr473residuelocatedwithinhelix12oftheligandbindingdomain(LBD).Instead,SPPARM2wasfoundtobindtoandactivatehumanPPARinwhichtheTyr473residuehadbeenmutatedtoalanine(hPPARY473A),withpotenciessimilartothoseobservedwiththewild-typerece...
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RelationbetweentheresponsetoironsupplementationandsicklecellhemoglobinphenotypeinpreschoolchildreninwesternKenya
...n1EffectsofironsupplementationonmalariaMalariasmearresultswereavailablefrom473childrenonamonthlybasis;214smearsfrom143ofthesechildrenwerefoundtobepositive.Ofthechildrenwhowereparasitemicatbaseline,41.4%wereparasitemicatthefirst4-wkfollow-up,despitethetreatmentdoseofSPreceivedbyallchildrenatbaseline....
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Therelationbetweenintraocularpressurepeakinthewaterdrinkingtestandvisualfieldprogressioninglaucoma
...tionallossinglaucoma.LIIEdwardJacksonMemorialLecture.AmJOphthalmol1996;121:473–83.ZeimerR.Circadianvariationsinintraocularpressure.In:RitchR,ShieldsMB,KrupinT,eds.Theglaucomas.StLouis:CVMosbyCo,1996.HughesE,SpryP,DiamondJ.24-hourmonitoringofintraocularpressureinglaucomamanagement:aretrospectiverev...
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EffectofmultivitaminandvitaminAsupplementsonweightgainduringpregnancyamongHIV-1-infectedwomen
...ndsofweightgainwereestimatedbyusingcubicsplines(33).Themultivitamingroup(n=473)includedthosesubjectsassignedtoreceivemultivitaminsonlyormultivitaminsplusvitaminA.Inthisgroup,therateofweightgainbecameprogressivelyhigherovertime(P=0.06fortheratedifferenceatweek36accordingtotheWaldtest).The“nomultivi...
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Carotenoidsandcoloncancer
...idsinhumanplasmabyhighperformanceliquidchromatography.JLiqChromatogr1985;8:473–84.RockCL.Carotenoids:biologyandtreatment.PharmacolTher1997;75:185–97.SteinmetzKA,PotterJD.Vegetables,fruit,andcancer.I.Epidemiology.CancerCausesControl1991;2:325–57.PotterJD,SlatteryML,BostickRM,GapsturSM....
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InfrarenalAorticDiameterPredictsAll-CauseMortality
...orticaneurysm:resultsfromaprospectivemulticentricstudy.AnnVascSurg.1997;11:473–481.BradyA,FowkesF,ThompsonS,PowellJ.Aorticaneurysmdiameterandriskofcardiovascularmortality.ArteriosclerThrombVascBiol.2001;21:1203–1207.NewmanA,ArnoldA,BurkeG,O’LearyD,ManolioT.Cardiovasculardiseaseandmortalityinol...
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Aproinflammatorystateisassociatedwithhyperhomocysteinemiaintheelderly
...tal.Changesinplasmahomocyst(e)ineintheacutephaseafterstroke.Stroke.2002;33:473–8.BoysenG,BranderT,ChristensenH,etal.Homocysteineandriskofrecurrentstroke.Stroke.2003;34:1258–61.McLeanRR,JacquesPF,SelhubJ,etal.Homocysteineasapredictivefactorforhipfractureinolderpersons.NEnglJMed2004;350:2042...
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MidlifePulsePressureandIncidenceofDementia
...iforniaAlzheimer’sDiseaseDiagnosticandTreatmentCenters.Neurology.1992;42:473–480.NewmanAB,Sutton-TyrrellK,VogtMT,KullerLH.Morbidityandmortalityinhypertensiveadultswithalowankle/armbloodpressureindex.JAMA.1993;270:487–489.TheExpertCommitteeontheDiagnosisandClassificationofDiabetesMellitus:Repor...
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Bodymassindexandwaistcircumferenceinmidchildhoodandadversecardiovasculardiseaseriskclusteringinadolescence
...:5.9–8.5y).Atbaselinetherewasnosignificantdifferenceinmeanheight(P=0.473),weight(P=0.929),BMI(P=0.379),orwaistcircumferencezscores(P=0.539)betweentheyoungpeoplewhowerefollowedupandthosewhowerenot.Neitherwasthereanysignificantdifferenceatbaselineinthenumberwhowereclassifiedasoverweightorobesede...
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DietandriskofischemicheartdiseaseinIndia
...kPL.Transfattyacidsandtheireffectsonlipoproteininhumans.AnnuRevNutr1995;15:473–93.LichensteinAH,AusmanLM,JalbertSM,SchaefferEJ.Effectsondifferentformsofdietaryhydrogenatedfatsonserumlipoproteincholesterollevels.NEnglJMed1999;340:1933–40.ReceivedforpublicationNovember1,2002.Acceptedforpubli...
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ConjugatedBileAcidsRegulateHepatocyteGlycogenSynthaseActivityInVitroandInVivoviaGiSignaling
...gmaChemical(St.Louis,MO).Phospho-/total-ERK1/2,Phospho-/total-GSK3,anti-Ser473AKT,anti-Thr308AKT,andtotalAKTwerepurchasedfromCellSignalingTechnology(Danvers,MA).Allofthesecondaryantibodies(anti-rabbit-HRP,anti-mouse-HRP,andanti-goat-HRP)werepurchasedfromSantaCruzBiotechnology(SantaCruz,CA).ThePI3kin...
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试管婴儿出生后健康状况队列研究的Meta分析
...ssessmentofbabiesconceivedbyinvitrofertilization.JPerinatal，1997，17(6):473-476. 3MerlobP，SapirO，SulkesJ，etal.Theprevalenceofmajorcongenitalmalformationsduringtwoperiodsoftime，1986～1994and1995～2002innewbomsconceivedbyassistedreproductiontechnology.EurJMedGenet，2005，48(1):5-11...
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AssociationofaFunctionalPolymorphismintheClopidogrelTargetReceptorGene,P2Y12,andtheRiskforIschemicCerebrovascularEventsinPatientsWithPer
...rWindows(Version10.0;SPSSInc)andStata(release8.0).ResultsPatientsWeincluded473of535patients(88%)whowereadmittedwithsymptomaticPADduringthestudyperiod.62patients(12%)hadtobeexcludedbecauseofincompletefollow-updataormissingsamplesforDNAanalysis.Patientswithincompleteormissingdatacomparedwelltopatients...
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ConjugatedLinoleicAcidImpairsEndothelialFunction
...ations:implicationsfortheriskofischaemicheartdisease.CoronArteryDis.1998;9:473-481.TuomilehtoJ,LindstromJ,ErikssonJG,ValleTT,HamalainenH,Ilanne-ParikkaP,Keinanen-KiukaanniemiS,LaaksoM,LouherantaA,RastasM,SalminenV,UusitupaM.Preventionoftype2diabetesmellitusbychangesinlifestyleamongsubjectswithimpair...