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Ligationofprotease-activatedreceptor1enhancesv?6integrin-dependentTGF-?activationandpromotesacutelunginjury
...eventintegrininteractionwiththeactincytoskeleton,eachabolishTGF-?activationbyv?6(1).ActivationofTGF-?byv?6probablyrequiresmorethansimplybindingtoLAP,aswehaveidentifiedcytoplasmicmutantsthatbindLAPbutdonotactivateTGF-?.Furthermorethev?1(13)and8?1integrins(14)arebothabletobindLAPbutdonotactivateTGF-?....
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AutomatedDeliveryofCITherapyWithReducedEffortbyTherapists
...rextendedperiodsshortlyaftertheendoftreatment.Themedicalproblemswerejudged(byV.W.M.)tobeunrelatedtoparticipationinthisstudy.ResultsandDiscussionTherewerenosignificantdifferencesbeforetreatmentbetweenthe100%,50%,and25%supervisiongroupsontheMALandWMFTorinthedemographicorstrokecharacteristicsmeasured(T...
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OxidizedPhospholipidsAlterVascularConnexinExpression,Phosphorylation,andHeterocellularCommunication
...KanemitsuMY,LooLW,SimonS,LauAF,EckhartW.Tyrosinephosphorylationofconnexin43byv-SrcismediatedbySH2andSH3domaininteractions.JBiolChem.1997;272:22824-22831.作者单位：DepartmentofMolecularPhysiologyandBiologicalPhysics(B.E.I.,B.R.D.),RobertM.BerneCardiovascularResearchCenter(B.E.I.,G.K.,A.K.,N.L.,B...
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V14NKTcell–triggeredIFN-productionbyGr-1+CD11b+cellsmediatesearlygraftlossofsyngeneictransplantedislets
...atGr-1+CD11b+cellsgeneratedbytransplantationandtheirIFN-productiontriggeredbyV14NKTcellsareanessentialcomponentandamajorcauseofearlygraftlossofpancreaticislettransplants.Gr-1+CD11b+cellsfromV14NKTcell–deficient(J281–/–)micefailedtoproduceIFN-,resultinginefficientisletgraftacceptance.Earlygraft...
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-MSHpreventsimpairmentinrenalfunctionanddysregulationofAQPsandNa-K-ATPaseinratswithbilateralureteralobstruction
...mexcretionsexpressedasfractionofamountdeliveredfromthedistalnephronaregivenbyV/CLiandCNa/CLi,respectively(46).DifferentlytreatedgroupswerecomparedusingANOVAtechniquesfollowedbyDunnett‘stestforindividualcomparisonsbetweengroupmeans,orcomparisonsbetweengroupsweremadebyanunpairedt-test.APvalue<0.05wa...
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DevelopmentalcontrolofCD8+Tcell–aviditymaturationinautoimmunediabetes
...17.6rearrangementsthatwereseenin9-week-oldmicewerereplacedin20-week-oldmicebyV17.5rearrangements(Figure1A).ItisimportanttoemphasizeherethatthevastmajorityoftheseTCR-rearrangementsemployingdifferentV17elementssharedidenticalV-Jjunctionalsequences,whichsuggeststhatV17elementusageperseplaysaroleintheav...
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Apoptosis-InducingLigand-InducedApoptosisbyUp-RegulationofCaspase-WithoutAlteringChemosensitivity
...ine2000(Invitrogen,Karlsruhe,Germany).Thewtcaspase-8vectorwaskindlyprovidedbyV.Castle(UniversityofMichigan,AnnArbor,MI);andthemutcaspase-8vector,byV.Kidd(St.JudeChildren??sResearchHospital,Memphis,TN).Twenty-fourhoursaftertransfections,cellsweretreatedwithrhTRAIL(100ng/ml)orwithvariousconcentrations...
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SharedreactivityofV2negTcellsagainstcytomegalovirus-infectedcellsandtumorintestinalepithelialcells
...hesedatalendfurthersupporttotheconclusiondrawnfromCMV-infectedpatientswherebyV2negTcellsubsetsmostlikelyexpandorareredistributedfromthetissueswheretheyresidenormallyandwhicharepreferentialsitesofCMVmultiplication(e.g.,intestinalepithelia,liver,orsalivaryglands).Thegoalofthepresentstudyistodefinethei...