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MartekBiosci与英国石油共同开发先进的生质燃料
...ightmicrobecouldpotentiallyhelplowercosts.London-basedBPwillinitiallycontribute$10milliontotheproject,andColumbia,Maryland-basedMartekwillconducttheresearchanddevelopment.Asanalternativetoconventionalvegetableoils,webelievesugar-to-dieseltechnologyhasthepotentialtodelivereconomic,sustainableandscala...
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NatChemBiol：蛋白质药物开发迎来新酶参与
...抑郁和抗压功能。研究者JamesTam表示，我们新发现的名为Butelase-1的酶类可以扮演连接酶的作用，将多肽或者蛋白质进行连接。这种新型分子或许可以作为一种工具来帮助进行蛋白质生物技术的研究，并且开发新型的多肽及蛋白质...
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RacialVariationsinLocationandRiskofIntracerebralHemorrhage
...Itisalsopossiblethatother,lesswell-definedriskfactors(perhapsgenetic)contributetodifferentratesandpatternsofICHinblacksandwhites.Whencomparinggenders,overallincidenceratesweresimilarinmenandwomen(RR,1.1).However,menhadhigherratesofdeepcerebralICH,whereasriskforlobarICHwasmarginallygreaterforwomenbec...
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甲状腺功能亢进性心脏病左心结构与功能临床研究
...earlyHHDandthosewithsimplehyperthyroidismandcontrolsshowedLVMIwashighinHHD,butE/Awaslower(F=5.47,20.32;q=4.93-5.10;P0.05).EFinpatientswithHHDinlatestagewaslowerthanthenormalones(F=5.03,q=4.87;P<0.01),andEFinthosewithsimplehyperthyroidismwashigher(q=5.02,P<0.01).ConclusionThesystolicfunctionofleftven...
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甲状腺功能亢进性心脏病病人左心室结构与功能变化
...hyroidismandnormalcontrolsshowedLVMIwashigh（F=5.47,q=4.93-5.04,P<0.01）,butE/Awaslow（F=5.03,q=4.98-5.10,P0.05）.EFofthepatientswiththyrotoxicheartdiseaseinlatestagewaslowerthanthenormalones（q=4.87,P<0.01）,andEFinthosewithsimplehyperthyroidismwashigher（q=5.02,P<0.01）.ConclusionThesystol...
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PerformanceoftheNewVITEK2GPCardforIdentificationofMedicallyRelevantGram-PositiveCocciinaRoutineClinicalLaboratory
...ons.INTRODUCTIONHighlyautomatedidentificationsystemsarenowadayswidelydistributedinmanymedium-to-high-throughputclinicalmicrobiologylaboratories.Thesesystemsimprovethequalityofpatientcareandenablemore-cost-effectivemanagementofthesamebyenablingclinicalmicrobiologiststoidentifymedicallyrelevantbacteri...
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ProbioticsupplementationreducesabiomarkerforincreasedriskoflivercancerinyoungmenfromSouthernChina
...orboth,hadbeenusedduringthepreceding2moby21students(25%)whowereevenlydistributedbetweenthe2studygroups.TheprotocolwasapprovedbytheEthicalCommitteesatKuopioUniversity(Finland)andSunYat-SenUniversity(China).TheproceduresfollowedwereinaccordancewiththeHelsinkiDeclarationof1975asrevisedin1983.Studydesig...
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TheEpidemiologyofIntestinalMicrosporidiosisinPatientswithHIV/AIDSinLima,Peru
...thanincreasedriskofmicrosporidiosis.Watermelonconsumptionwashighlyseasonal,butE.bieneusidetectionsshowednosignificantassociationwithseason,andtheinclusionofseasoninthemodeldidnotaltertheestimatesforassociationofE.bieneusiinfectionwithwatermelonconsumption.Thesefactorswereexaminedseparatelyaccordingt...
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IcilinActivatesthe-SubunitoftheHumanEpithelialNa+Channel
...bunithasnotyetbeenidentified.Morerecently,wehaveshownthatENaCiswidelydistributedthroughoutthebrainandisactivatedbyprotons,indicatingthatitmayactasapHsensorinthehumanbrain(Yamamuraetal.,2004b).Inaddition,wehavedemonstratedthatcapsazepineisthefirstchemicalagonistforENaC(Yamamuraetal.,2004a).Inthisinve...
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ValidationoftheHealthyEatingIndexwithuseofplasmabiomarkersinaclinicalsampleofwomen
...y.Mixtureswerebrokendownintotheircomponentpartssothatasingleitemcouldcontribute2pointstothevarietyindex.Forexample,lasagnawouldcontributetothegrainandmeatgroups.Athresholdcriterionensuredthatfoodswerecountedonlyiftheycontributedatleastone-halfofaservinginanyofthefoodgroups.HEIscoreswerecalculatedbyu...
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HIV-1GeneticDiversitySurveillanceintheUnitedStates
...getedsurveillanceportionoftheirMinnesotastudy.African-bornindividualscontribute20%ofnewHIVreportsinMinnesota,resultinginageneticallydiverseHIVepidemic.Thesefindings,fromastatewhereAfrican-bornindividualsmakeup1%ofthepopulation,suggestthatitmaybetimetoconsiderHIVgeneticdiversitysurveillanceintheUnite...
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Proteinrequirementsduringthefirstyearoflife
...proteinrequirementsduringinfancyof10–26%.Partofthedifferencecanbeattributedtobettermeasurementsofproteinintakeinbreastfedinfantsandhigherestimatesofutilizationofnonproteinnitrogen(NPN)frombreastmilk.However,asignificantconceptualdifferencewasalsointroduced:thatthemeanproteinintakemaybedistinctf...
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GBVirusCCoinfectionandHIV-1DiseaseProgression:TheAmsterdamCohortStudy
...ossofGBV-CspecificE2antibodieshadnoobservedeffectonHIV-1diseaseprogression,butE2-antibodypersistencewasanindependentpredictorformore-rapidemergenceofSIHIV-1variants.Thediscrepanciesbetweenpreviousstudiesmostlikelyreflectdifferencesintheclinicalstageofsubjects‘HIV-1infectionatbaselineandapotentialm...
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MolecularBasisofCellMembraneEstrogenReceptorInteractionWithPhosphatidylinositol3-KinaseinEndothelialCells
...snotdetectableinMCF-7cellsinsimilarconditionsPI3KstainingisnotaffectedbyE2,butE2favorsthecolocalizationofERandp85inthecytoplasmic/cellmembranecompartment,althoughanuclearinteractioncannotbecompletelyexcludedbytheseexperiments.Toconfirmtheseobservations,weobtainedpurifiednuclearandcytoplasmic/cellmem...
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E47isrequiredforV(D)Jrecombinaseactivityincommonlymphoidprogenitors
...+DCprogenitors,andLy6C+myeloidandplasmacells(2,17,18),populationsthatcontributesignificantcontaminationtotheBlineageprogenitorgates.Wefoundthatpro–/pre–BcellswerevirtuallyundetectableinE47-nullmice.Thispopulationwasreducedfrom65–82%inE47-heterozygousanimalsto0–0.2%inE47-deficientanimals(Fig....