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KnockdownexpressionandhepaticdeficiencyrevealanatheroprotectiveroleforSR-BIinliverandperipheraltissues
...atory,GenomicsDivision,Berkeley,California,USA.AbstractScavengerreceptorSR-BIhasbeenimplicatedinHDL-dependentatheroprotectivemechanisms.WereportthegenerationofanSR-BIconditionalknockoutmousemodelinwhichSR-BIgenetargetingbyloxPsiteinsertionproducedahypomorphicallele(hypomSR-BI).AttenuatedSR-BIexpress...
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HepaticexpressionofscavengerreceptorclassBtypeI(SR-BI)isapositiveregulatorofmacrophagereversecholesteroltransportinvivo
...sylvania,USA.AbstractHepaticexpressionofthescavengerreceptorclassBtypeI(SR-BI)promotesselectiveuptakeofHDLcholesterolbytheliverandisbelievedtoplayaroleintheprocessofreversecholesteroltransport(RCT).WehypothesizedthathepaticSR-BIexpressionisaregulatoroftherateofintegratedmacrophage-to-fecesRCTandused...
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RelativeContributionsofABCA1andSR-BItoCholesterolEffluxtoSerumFromFibroblastsandMacrophages
...tohumanserum.MethodsandResults-HumanfibroblastswerestablytransfectedwithSR-BIwhileABCA1wasupregulated.Quantitationofcholesteroleffluxtohumanserumdemonstratedthattherewaseffluxfromcellswithouteitherprotein.ExpressionofABCA1producedasmallincreaseinefflux,whereasSR-BIexpressionhadadramaticimpact.Toquan...
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Cholesterolbinding,efflux,andaPDZ-interactingdomainofscavengerreceptor–BImediateHDL-initiatedsignaling
...ia,Pennsylvania,USA.5DepartmentofMedicine,DivisionofMolecularMedicine,ColumbiaUniversityCollegeofPhysiciansandSurgeons,NewYork,NewYork,USA.AbstractThebindingofHDLtoscavengerreceptor–BI(SR-BI)mediatescholesterolmovement.HDLalsoinducesmultiplecellularsignals,whichinendotheliumoccurthroughSR-BIandcon...
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DifferentialAdditiveEffectsofEndothelialLipaseandScavengerReceptor-ClassBTypeIonHigh-DensityLipoproteinMetabolisminKnockoutMouseModels
...crinologyandMetabolism(K.M.,L.C.),DepartmentsofMedicineandMolecularCellularBiology,BaylorCollegeofMedicine,andSt.Luke’sEpiscopalHospital,Houston,Tex;LawrenceBerkeleyNationalLaboratory(T.F.),Berkeley,Calif;andLipoScience(J.D.O.),Raleigh,NC.CorrespondencetoLawrenceChan,DivisionofEndocrinologyMetabol...
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CholesterylEsterTransferProtein(CETP)ExpressionProtectsAgainstDietInducedAtherosclerosisinSR-BIDeficientMice
...ssionofthehumanCETPtransgeneprotectsagainstdiet-inducedatherosclerosisinSR-BIdeficientmice.MethodsandResults-SR-BIdeficient(-/-)micewerecrossedwithCETPtransgenic(CETPtg)micetoproduceacolonyofSR-BI-/-xCETPtgmiceinaC57Bl/6background.Ageandsexmatchedgroupsofgeneticallymodifiedandwild-typeC57Bl/6micewer...
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HCV蛋白酶抑制剂BI201335有强效抗病毒活性
...林格殷格翰公司研发的丙肝病毒（HCV）NS3/4A蛋白酶抑制剂BI201335，在初治和经治的慢性基因1型丙肝病毒（HCV）感染患者中的优异疗效。基因1型的HCV是在所有HCV感染治疗中最有挑战性的基因分型。 丙型肝炎是肝脏感染性疾病...
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MacrophageApolipoproteinEReducesAtherosclerosisandPreventsPrematureDeathinApolipoproteinEandScavengerReceptor-ClassBIDouble-KnockoutMice
...】Objective-Micenullforbothapolipoprotein(apo)Eandscavengerreceptor(SR)-BI(DKO)developseverehypercholesterolemia,occlusivecoronaryatherosclerosis,myocardialinfarction,andprematuredeath.ThecurrentstudyexaminestheabilityofmacrophageapoEtoimprovethedyslipidemia,reduceatherosclerosis,andrescuethelethal...
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ScavengerReceptorClassBTypeIMediatestheSelectiveUptakeofHigh-DensityLipoprotein–AssociatedCholesterylEsterbytheLiverinMice
...H.G.,M.M.,F.R.),Hamburg,Germany;andtheCollegeofPhysiciansandSurgeonsofColumbiaUniversity(R.R.),NewYork,NY.CorrespondencetoDrFranzRinninger,UniversityHospitalHamburg-Eppendorf,DepartmentofMedicine,Martinistrasse52,20246Hamburg,Germany.E-mailRinninger@uke.uni-hamburg.deAbstractObjective—High-density...
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Bi-PAP呼吸机通气治疗慢性阻塞性肺疾病合并呼吸衰竭
【摘要】目的研究无创Bi-PAP呼吸机治疗慢性阻塞性肺疾病（COPD）合并呼吸衰竭。方法52例患者随机分为治疗组27例，持续Bi-PAP呼吸机治疗;对照组25例，持续低流量吸氧。两组同时抗感染等常规治疗。观察血气和临床症状变化。结...
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IncreasedOxidativeStressinScavengerReceptorBIKnockoutMiceWithDysfunctionalHDL
【摘要】Objective—InthecurrentstudytheeffectofdisruptionofSR-BI,aprominentregulatorofHDLmetabolism,ontheactivityoftheHDL-associatedantioxidantenzymesPON1andPAF-AHaswellasinvivooxidativestresswereinvestigated.MethodsandResults—SR-BIdeficiencyresultedin1.4-fold(P0.001)and1.6-fold(P0.01...
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Phosphatidylinositol-3-KinaseRegulatesScavengerReceptorClassBTypeISubcellularLocalizationandSelectiveLipidUptakeinHepatocytes
...ive-Thehigh-densitylipoprotein(HDL)receptorscavengerreceptorClassBtypeI(SR-BI)playsakeyroleinmediatingthefinalstepofreversecholesteroltransport.ThisstudyexaminedthepossibleregulationofhepaticSR-BIbyphosphatidylinositol-3-kinase(PI3K),awellknownregulatorofendocytosisandmembraneproteintrafficking.Meth...
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SR-BI受体基因的G4A位点多态性可能增加脑血管疾病风险
...硬化和脑缺血患者中均发现，B族I型清道夫受体基因（SR-BI，也称高密度脂蛋白受体）G4AGA+AA患者的高密度脂蛋白也明显升高，而低密度脂蛋白却低于GG基因患者。动脉粥样硬化是一个被广泛认可的中风独立危险因素，与脂代谢密...
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实时组织弹性成像与超声BI-RADS分级法在乳腺肿瘤性疾病诊断中的对比研究
...腺结节的实时组织弹性成像资料进行回顾分析，并与超声BI-RADS分级法对比，探讨两种方法在乳腺实性结节良恶性鉴别诊断中的价值。方法130例女性乳腺结节患者，常规高频彩超图像进行BI-RADS分级[1]，而后对实时弹性图像评分，...
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高密度脂蛋白抗动脉粥样硬化机制—SR-BI,CD36,PPARgamma的作用
高密度脂蛋白抗动脉粥样硬化机制—SR-BI,CD36,PPARgamma的作用南华大学心血管疾病研究所易光辉泡沫细胞形成是动脉粥样硬化发病的核心SR-BI动脉粥样硬化小型猪SR-BI、CD36和PPARγ表达的变化第一部分Figure1:Themeanbodyweightsofthetwog...
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海南省2007年登革热媒介伊蚊分布调查
...）、容器指数（ContainerIndex,CI）、布雷图指数（BreteauIndex,BI）等，以房屋指数、容器指数和布雷图指数，调查媒介幼虫密度；以捞取积水容器内蚊幼，调查孳生情况。结果全省BI值最高为123，最低为13.3，全省平均BI值37.4；CI值最...
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多菌型麻风联合化疗期满后麻风菌的活性及复发的研究
...色法检测麻风菌的活性，抗酸染色（AFB）记录细菌指数（BI）及形态指数（MI）。结果检测多菌型麻风患者共29例，其中初治MDT期满22例，复发MDT期满7例，共检出绿染菌4例。抗酸染色查菌阳性者中复发患者平均BI高于初治患者平均...
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Bi-PAP无创鼻罩呼吸机治疗慢性阻塞性肺疾病的护理
【摘要】目的探讨Bi-PAP无创鼻罩呼吸机治疗慢性阻塞性肺疾疾（COPD）呼吸衰竭的护理。方法35例COPD呼吸衰竭患者在常规治疗的同时，应用Bi-PAP呼吸机S/T模式辅助通气治疗。结果经无创正压通气，31例好转，4例病情加重予以气管...
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LymphocytesAreNotRequiredfortheRapidOnsetofCoronaryHeartDiseaseinScavengerReceptorClassBTypeI/ApolipoproteinEDoubleKnockoutMice
FromtheDepartmentofBiology(S.L.K.,M.K.),MassachusettsInstituteofTechnology,Cambridge;andDivisionofCardiologyDepartmentofMedicine(M.H.P.),MassachusettsGeneralHospitalandHarvardMedicalSchool,Boston,Mass.CorrespondencetoMontyKrieger,Room68-483,BiologyDepartment,MassachusettsInstituteofTechnology,Cambri...
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High-DensityLipoproteinPromotesEndothelialCellMigrationandReendothelializationviaScavengerReceptor-BTypeI
...rationinvitroinanitricoxide-independentmannerviascavengerreceptorBtypeI(SR-BI)-mediatedactivationofRacGTPase.ThisprocessdoesnotrequireHDLcargomolecules,anditisdependentontheactivationofSrckinases,phosphatidylinositol3-kinase,andp44/42mitogen-activatedproteinkinases.Rapidinitialstimulationoflamellipo...
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HepaticLipaseDeficiencyDelaysAtherosclerosis,MyocardialInfarction,andCardiacDysfunctionandExtendsLifespaninSR-BI/ApolipoproteinEDoubleKnockou
【摘要】Objective-SR-BI/apolipoprotein(apo)Edoubleknockout(dKO)miceexhibitmanyfeaturesofhumancoronaryheartdisease(CHD),includingocclusivecoronaryatherosclerosis,cardiachypertrophy,myocardialinfarctions,andprematuredeath.Herewedeterminedtheeffectsonthispathologyofhepaticlipase(HL)deficiency,which...
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NabelspeaksupaboutdirectingtheNHLBI
TheNationalHeart,Lung,andBloodInstitute(NHLBI)coversextensiveground,exploringcauses,prevention,therapy,anddiagnosisofdiseasesinvolvingtheheart,blood,bloodvessels,andlung.TheNHLBIalsoresearchessleepdisordersandcoordinatestheNIHWoman’sHealthInitiative.ElizabethNabel,formerlythescientificdirectorofcl...
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勃林格殷格翰启动肺癌新型第三代表皮生长因子受体抑制剂项目
勃林格殷格翰今天在德国慕尼黑召开的BIO欧洲会议上宣布启动一项全球II期试验，旨在评价BI1482694（HM61713）用于T790M突变阳性非小细胞癌患者的安全性和有效性，此类患者的肿瘤细胞已不再对现有表皮生长因子受体靶向治疗产生...
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DualPotentiatingandInhibitoryActionsofaBenz[e]indeneNeurosteroidAnalogonRecombinant122GABAAReceptors
【关键词】Benz[e]indene5µM),BI-2inhibitsreceptorfunctionbyenhancingtheapparentrateofdesensitization.Fromsingle-channelrecordings,weestimatethattheentryrateintotheinhibitedorblockedstate,k+B,is0.50µM-1s-1.Basedonthekineticmechanismofaction,andthefindingthatthiseffectisblockedbythe1V2...
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丹阳市40例麻风病人联合化疗临床疗效分析
...病人，皮损消退时间为2个月～3年，平均1.8年。表1MDT前后Bi变化略2.2细菌指数变化23例疗前查菌阳性者，MDT前皮肤查菌Bi平均1.77，联化治疗后Bi呈持续下降趋势，其中疗后2年内细菌Bi下降幅度较大，年均下降0.657，高于国外报道，...
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赛莱乐治疗42例缺血性脑卒中疗效观察
...莱乐150mg静脉点滴。疗程15天。结束后评定NFD程度、FMA及BI得分的变化，观察不良反应。结果2例赛莱乐组病人因不良反应退出观察，余82例完成观察。赛莱乐组、对照组的总有效率分别为83%、62%(P＜0.05)。治疗后NFD、FMA、BI评分分别...
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中山大学和杜塞尔多夫大学启动全球糖尿病项目
...博士共同担任全球协调牵头人的全球糖尿病项目（项目号BI1245.19和BI1245.20）的研究者会议在南京成功举行。中山大学附属第三医院、复旦大学附属华山医院、第二军医大学附属长征医院、首都医科大学附属北京同仁医院、卫生部...
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穴位敷贴对缺血性中风肢体偏瘫患者的疗效观察
...息3天后换取其他穴位再贴。1.6观察指标参照Barthal指数（BI）评分（表1）。表1Barthal指数（BI）注：*每周少于1次，**每24h少于1次。总积分由0～100分，按其依赖程度分，100分独立；75～95分轻度依赖；50～70分中度依赖；25～45分重度...
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创（dou）意（bi）发明：古有钻木取火，今有咀嚼发电
2014年9月18日讯/生物谷BIOON/钻木取火可以说是人类最早的能量转换方法之一，可以说这种方法大大加速了人类的进化。可是你是否曾设想过，有一天你可以在公园里吃汉堡的时候就可以为你的手机充电？最近，一年一度的搞笑诺...
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中山大学和德国杜塞尔多夫大学共同负责的全球糖尿病项目正式启动
...博士共同担任全球协调牵头人的全球糖尿病项目（项目号BI1245.19和BI1245.20）的研究者会议在南京中山国际会议中心成功举行。中山大学附属第三医院、复旦大学附属华山医院、第二军医大学附属长征医院、首都医科大学附属北京...