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治疗急性视网膜坏死综合征的临床体会
急性视网膜坏死(acuteretinalnecrosis,ARN)是临床上少见的一种致盲性眼底疾病,其特点是早期症状隐蔽、病情进展迅速、治疗效果较差等。对于这种疾病,许多眼科医生缺乏足够的认识,易造成漏诊误诊,而贻误最佳治疗时机。...
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急性视网膜坏死患者的护理
急性视网膜坏死综合征(acuteretinalnecrosissyndrome,ARN)是一种以视网膜坏死、视网膜动脉受累为主的血管炎、明显的玻璃体炎症反应和后期发生裂孔源视网膜脱离为特征的疾病。主要由于水痘—带状疱疹病毒和单纯疱疹病毒引起。1...
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急性视网膜坏死1例
...访3个月病情未再发展。 2讨论 急性视网膜坏死(ARN)是以急性葡萄膜炎、玻璃体炎、视网膜动脉闭塞性炎症、视网膜坏死、后期出现视网膜脱离为特征的严重致盲性眼病[1]。本病的病因尚不清楚,多数学者[2]认为...
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急性视网膜坏死误诊1例
急性视网膜坏死(acuteretinalnecrosis,ARN)是一种由疱疹类病毒感染引起的,以急性葡萄膜炎、视网膜血管炎及视网膜坏死和脱离为主要特征的眼部综合征[1]。本病起病急、发展快、预后差,因此早期诊断、早期治疗对本病有重...
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急性视网膜坏死误诊1例
急性视网膜坏死(acuteretinalnecrosis,ARN)是一种由疱疹类病毒感染引起的,以急性葡萄膜炎、视网膜血管炎及视网膜坏死和脱离为主要特征的眼部综合征[1]。本病起病急、发展快、预后差,因此早期诊断、早期治疗对本病有重...
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葡萄膜炎的研究进展棗第一届国际眼免疫和炎症联合会议概况
...-10和IFN-γ。 用ELISA对急性视网膜坏死(acuteretinalnecrosis,ARN)和眼弓形体病患者的眼内液进行测定,发现ARN眼内液中IL-6浓度显著高于对照组,IFN-γ水平在ARN患者高于弓形体性脉络膜炎和其它葡萄膜炎,对照组则测不出IFN-γ,IL-10水...
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Polymerasechainreactionanalysisofaqueoushumoursamplesinnecrotisingretinitis
...seroconversionwasevidencedinoneadditionalpatient.Intheacuteretinalnecrosis(ARN)group(n=19),varicellazostervirus(VZV)DNAwasidentifiedinsixpatients,herpessimplexvirus1(HSV-1)DNAintwopatients,herpessimplexvirus2(HSV-2)DNAinfourpatients,andcytomegalovirus(CMV)genomeinfourpatients.Intheprogressiveouterre...
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继承名医经验提高辨治水平——第二届中华中医药学会肾病分会全国学术交流大会观点撷要
...脑是调节食欲的中枢,内存着复杂的“食欲调节网络”(ARN)。ARN通过各种食欲调节因子(包括食欲促进因子和食欲抑制因子)的信号传递作用,对食欲进行调节。下丘脑神经肽Y(NPY)是ARN中主要的食欲促进因子,阿片-促黑素细...
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Necrotisingretinopathiessimulatingacuteretinalnecrosissyndrome
...entspresentingwithnecrotisingretinopathiesthatsimulateacuteretinalnecrosis(ARN).Methods:Retrospectivenon-comparativecaseseries.Thechartsof16patientspresentingwithaclinicalimpressionofARNatPitié-SalpêtrièreHospital,Paris,France,between1994and1999,whorequiredinitialantiviraltherapywerereviewed.Allo...
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MitochondrialExpressionoftheDrosophilamelanogasterMultisubstrateDeoxyribonucleosideKinase
...tytoaraTandBVDU,whichinnontransducedcellsarepreferredsubstratesforhumanTK2(Arnéretal.,1992;Franzolinetal.,2006),haspreviouslybeenshowntodramaticallyincreasebytheexpressionofwtDm-dNK(Zhengetal.,2000,2001b).AvaTandBVDUshowedanevenhighertoxicityincellswhereDm-dNKwastargetedtothemitochondria.Theh...
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B超多参数预测胎儿体重484例分析
...bymeasuringBPD,ACandFLhashigheraccuracy,Themethodformeasurementiseasytolearn. 【Keywords】biparietaldiameter,abdominalcircumference,femurlengh,estimatedfetalweight,actualbirthweight 分娩以前准确估计胎儿体重对决定分娩方式有重要的指导意义。临床上根据宫...
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生物芯片与基因发现
...离子转运系统中的一个组分Fet3p表达在细胞膜上;然而,Arn3p高铁离子介导转运系统表达在细胞内小泡。 在药物研发过程中高通量的基因表达分析扮演着一个重要的角色。用微矩阵,可以在基因组水平上来检测基因表达,可...
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《科学》:生物芯片与基因发现
...离子转运系统中的一个组分Fet3p表达在细胞膜上;然而,Arn3p高铁离子介导转运系统表达在细胞内小泡。 在药物研发过程中高通量的基因表达分析扮演着一个重要的角色。用微矩阵,可以在基因组水平上来检测基因表达,可...
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《科学》:生物芯片与基因发现
...离子转运系统中的一个组分Fet3p表达在细胞膜上;然而,Arn3p高铁离子介导转运系统表达在细胞内小泡。 在药物研发过程中高通量的基因表达分析扮演着一个重要的角色。用微矩阵,可以在基因组水平上来检测基因表达,可...
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HypoxiaConvertsHumanMacrophagesIntoTriglyceride-LoadedFoamCells
...estJP,KimmelAR.Perilipins,ADRP,andotherproteinsthatassociatewithintracellularneutrallipiddropletsinanimalcells.SeminCellDevBiol.1999;10:51-58.LuX,Gruia-GrayJ,CopelandNG,GilbertDJ,JenkinsNA,LondosC,KimmelAR.Themurineperilipingene:thelipiddroplet-associatedperilipinsderivefromtissue-specific,mRNAsplic...
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维生素A对SD大鼠食欲及下丘脑神经肽Y基因表达的影响
...作、相互影响,形成了一个复杂的“食欲调节网络(ARN),其中众多的食欲调节因子(包括多种食欲促进因子和抑制因子)起着极其重要的信息传递作用。在下丘脑食欲调节网络中,NPY是下丘脑中最重要的食欲促进因子,神...
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Associationsofsizeatbirthanddual-energyX-rayabsorptiometrymeasuresofleanandfatmassat9to10yofage
...RReilly,JonTobiasandGeorgeDaveySmith1FromtheDepartmentofSocialMedicine(ISR,ARN,CDS,PME,andGDS),UniversityofBristol,Bristol,UnitedKingdom;theMRCChildhoodNutritionResearchCentre,InstituteofChildHealth,London,UnitedKingdom(JCKW);theDivisionofDevelopmentalMedicine,UniversityofGlasgow,YorkhillHospitals,G...
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SensitiveandRapidDetectionofHerpesSimplexVirusandVaricella-ZosterVirusDNAbyLoop-MediatedIsothermalAmplification
...calsymptoms,forexample,cutaneousvesicles,keratitis,andacuteretinalnecrosis(ARN),andthecausativeagentcannotbedistinguishedbasedontheclinicalfeatures.However,differentclinicalcoursesandprognosesarecausedbyeachvirus.HSV-2genitalherpestendstorecur,butHSV-1genitalherpesdoesnot(7).VZVARNissevererandhasawo...
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地震所致挤压综合征的早期诊治
...7例血钙降低(1.25~2.09mmol/L,平均值1.71mmol/L)。21例合并ARN患者入院后均接受血液透析治疗,透析3~6次/周,平均4.3次/周。6例患者肌酐水平轻度升高,平均164μmol/L,CK平均8723IU/L,无少尿。1.3治疗所有患者入院后均立即...
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Acuteunilateralureteraldistensioninhibitsglutamate-dependentspinalpelvic-urethrareflexpotentiationviaGABAergicneurotransmissioninanesthetizedra
...P.Science252:722-724,1991.MartinezJLJr,DerrickBE.Long-termpotentiationandlearning.AnnuRevPsychol47:173-203,1996.MayerML,WestbrookGL,GuthriePB.Voltage-dependentblockbyMg2+ofNMDAresponsesinspinalcordneurones.Nature309:261-263,1984.MayerML,WestbrookGL.Thephysiologyofexcitatoryaminoacidsinthevertebratec...
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IdFamilyofTranscriptionFactorsandVascularLesionFormation
...SMCtargetsofCHF1areunknown.33Lastly,theclassVIIHLHproteinscontainabHLH-Per-Arnt-Sim(bHLH-PAS)domain.bHLH-PASfactorsimplicatedinVSMCandinvasculardiseaseincludehypoxia-induciblefactor1,whichregulatesexpressionofplasminogenactivatorinhibitor-1andvascularendothelialgrowthfactorsinVSMC,34andtheclockprote...
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TargetedTransgenicOverexpressionofMitochondrialThymidineKinase(TK)AltersMitochondrialDNA(mtDNA)andMitochondrialPolypeptideAbundance
...edexperimentallyusingtargetedtransgenesisandNRTIadministrationtocreatesimilarnucleotidepoolimbalances.Insummary,thisstudyusedTGsthatindividuallyexpressedmitochondrial(TK2)orcytoplasmic(hTK1)isoformsofTKinthemurinehearttodefineinvivoeventscontrollingmtDNAreplicationandNRTItoxicity.InTK2TGs,mtDNAabund...
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Protease-ActivatedReceptor-AugmentsExperimentalCrescenticGlomerulonephritis
...rotein-coupledreceptorsthatisactivatedbyproteolyticcleavageofitsextracellularN-terminaldomain.PAR-2isactivatedbyserineproteasessuchastrypsin,tryptase,1,2andcoagulationfactorsVIIaandXa.3ProteolyticcleavageresultsinexposureofanewNterminusthatactsasatetheredligandthatbindsandactivatesthereceptor.PAR-2i...
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GeneralizedLysosome-AssociatedMembraneProtein-DefectExplainsMultisystemClinicalInvolvementandAllowsLeukocyteDiagnosticScreeninginDanonDisease
...y(Danondisease).AnnNeurol2002,52:122-125Lacoste-CollinL,GarciaV,Uro-CosteE,Arn-BesMC,DurandD,LevadeT,DelisleMB:Danon??sdisease(X-linkedvacuolarcardiomyopathyandmyopathy):acasewithnovelLAMP-2genemutation.NeuromusculDisord2002,12:882-885HorvathJ,KetelsenUP,Gaibel-ZehenderA,BoehmN,OlbrichH,Korinthenber...
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Notch1modulatestimingofG1-SprogressionbyinducingSKP2transcriptionandp27Kip1degradation
...esothelialcells.Oncogene.22:81–89.Sriuranpong,V.,M.W.Borges,R.K.Ravi,D.R.Arnold,B.D.Nelkin,S.B.Baylin,andD.W.Ball.2001.Notchsignalinginducescellcyclearrestinsmallcelllungcancercells.CancerRes.61:3200–3205.Varnum-Finney,B.,C.Brashem-Stein,andI.D.Bernstein.2003.CombinedeffectsofNotchsignalingandcy...