查看“胃复春”的源代码

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            <strong>[[胃复春]]</strong>（<strong>[[Weifuchun]]</strong>）是由“江南药王”<strong>[[胡庆余堂]]</strong>独家生产的经典中成药，主要剂型为片剂。该药是中国药监局（NMPA）批准的首个明确用于治疗<strong>[[胃癌癌前病变]]</strong>（Precancerous Lesions of Gastric Cancer, <strong>[[PLGC]]</strong>）的药物。其组方包含<strong>[[红参]]</strong>、<strong>[[香茶菜]]</strong>和<strong>[[枳壳]]</strong>三味药材，具有健脾益气、活血解毒的功效。在临床上，[[胃复春]]被广泛用于治疗<strong>[[慢性萎缩性胃炎]]</strong>（CAG）及其伴随的<strong>[[肠上皮化生]]</strong>（IM）和<strong>[[异型增生]]</strong>（Dysplasia），是消化内科阻断“炎-癌”转化链条的标志性药物。
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            <div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">[[胃复春]]</div>
            <div style="font-size: 0.75em; opacity: 0.85; margin-top: 4px;">Weifuchun / 胃癌阻断药 · 点击展开</div>
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                <div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;">核心成分：[[冬凌草甲素]]</div>
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                    <th style="text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; width: 45%;">生产企业</th>
                    <td style="padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">[[杭州胡庆余堂]]</td>
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                    <th style="text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">药物类型</th>
                    <td style="padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;">[[中成药]] / [[处方药]]</td>
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                    <th style="text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">批准文号</th>
                    <td style="padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">国药准字Z33020455</td>
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                    <th style="text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">核心适应症</th>
                    <td style="padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">[[萎缩性胃炎]]、[[癌前病变]]</td>
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                    <th style="text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">君臣佐使</th>
                    <td style="padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">红参(君)、香茶菜(臣)</td>
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                    <th style="text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569;">医保属性</th>
                    <td style="padding: 12px; color: #0f172a;">国家医保乙类</td>
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        胃复春的组方精简而严谨，仅由三味药组成，体现了中医“扶正祛邪”的治疗思路，其现代药理机制已得到深入研究：
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        <li style="margin-bottom: 12px;"><strong>红参 (Radix Ginseng Rubra)：</strong>作为君药，富含[[人参皂苷]]，具有大补元气、健脾益胃之功。现代研究表明其能提高机体免疫力，改善胃黏膜血流，促进受损黏膜修复。</li>
        <li style="margin-bottom: 12px;"><strong>香茶菜 (Isodon amethystoides)：</strong>作为臣药，清热解毒、活血止痛。其核心活性成分为<strong>[[冬凌草甲素]]</strong>（Oridonin, $C_{20}H_{28}O_{6}$），已被证实具有显著的抗肿瘤活性，能诱导胃癌细胞凋亡，抑制[[幽门螺杆菌]]（Hp）活性。</li>
        <li style="margin-bottom: 12px;"><strong>枳壳 (Fructus Aurantii)：</strong>作为佐使药，理气宽中，行滞消胀。调节胃肠动力，缓解胃脘胀痛等临床症状。</li>
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    <h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">临床应用：阻断炎癌转化</h2>

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        胃复春在消化科的主要临床价值在于对<strong>[[Correa级联反应]]</strong>（正常胃黏膜→浅表性胃炎→萎缩性胃炎→肠化生→异型增生→胃癌）的干预：
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                <th style="padding: 10px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%;">病程阶段</th>
                <th style="padding: 10px; border: 1px solid #cbd5e1; color: #475569;">病理特征</th>
                <th style="padding: 10px; border: 1px solid #cbd5e1; color: #1e40af;">胃复春的治疗目标</th>
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                <td style="padding: 8px; border: 1px solid #cbd5e1; font-weight: 600;">[[慢性萎缩性胃炎]]<br>(CAG)</td>
                <td style="padding: 8px; border: 1px solid #cbd5e1;">胃黏膜固有腺体减少，变薄。</td>
                <td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>逆转萎缩</strong>：促进腺体再生，改善胃黏膜微循环。</td>
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                <td style="padding: 8px; border: 1px solid #cbd5e1; font-weight: 600;">[[肠上皮化生]]<br>(IM)</td>
                <td style="padding: 8px; border: 1px solid #cbd5e1;">胃黏膜上皮被肠型上皮取代。</td>
                <td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>控制进展</strong>：抑制肠化生范围扩大，调节胃内微环境。</td>
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                <td style="padding: 8px; border: 1px solid #cbd5e1; font-weight: 600;">[[异型增生]]<br>(Dysplasia)</td>
                <td style="padding: 8px; border: 1px solid #cbd5e1;">细胞结构和形态出现异型性（最接近癌）。</td>
                <td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>阻断癌变</strong>：通过“解毒”机制清除异常细胞，为内镜下治疗（ESD）提供辅助或替代方案。</td>
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                <td style="padding: 8px; border: 1px solid #cbd5e1; font-weight: 600;">[[胃癌术后]]</td>
                <td style="padding: 8px; border: 1px solid #cbd5e1;">脾胃虚弱，免疫力低下。</td>
                <td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>扶正固本</strong>：提高化疗耐受性，改善术后生存质量。</td>
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            <li style="margin-bottom: 8px;"><strong>[[PLGC]]：</strong>Gastric Precancerous Lesions，即胃癌癌前病变，包括萎缩、肠化和异型增生。胃复春是针对此阶段的代表药物。</li>
            <li style="margin-bottom: 8px;"><strong>[[冬凌草甲素]] (Oridonin)：</strong>香茶菜中的二萜类化合物，是胃复春发挥抗肿瘤、抗炎作用的关键物质基础。</li>
            <li style="margin-bottom: 8px;"><strong>[[脾虚瘀毒]]：</strong>中医对胃癌前病变的核心病机认识，即“脾虚为本，瘀毒为标”，胃复春的配伍正是针对此病机。</li>
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        <span style="color: #0f172a; font-weight: bold; font-size: 1.05em; display: inline-block; margin-bottom: 15px;">学术参考文献与权威指南</span>
        
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            [1] <strong>Chinese Society of Gastroenterology. (2022).</strong> <em>Consensus on Integrated Traditional Chinese and Western Medicine for Chronic Atrophic Gastritis.</em> <strong>[[Chinese Journal of Integrated Traditional and Western Medicine on Digestion]]</strong>.<br>
            <span style="color: #475569;">[权威共识]：该专家共识明确推荐[[胃复春]]用于治疗慢性萎缩性胃炎伴肠化生或异型增生，以逆转病理改变。</span>
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            [2] <strong>Zhang, J., et al. (2020).</strong> <em>Weifuchun tablet suppresses the progression of gastric precancerous lesions by inhibiting the Sonic Hedgehog pathway.</em> <strong>[[Journal of Ethnopharmacology]]</strong>.<br>
            <span style="color: #475569;">[循证医学]：发表于国际民族药理学杂志的研究，揭示了胃复春通过抑制Shh信号通路阻断胃癌前病变进展的分子机制。</span>
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            [[胃复春]] (Weifuchun) 诊疗生态 · 知识图谱
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                <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">关联疾病</td>
                <td style="padding: 10px 15px; color: #334155;">[[慢性胃炎]]•[[肠上皮化生]]•[[胃癌]]•[[幽门螺杆菌感染]]</td>
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                <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">竞品药物</td>
                <td style="padding: 10px 15px; color: #334155;">[[摩罗丹]]•[[胃苏颗粒]]•[[养胃舒]]•[[替普瑞酮]]</td>
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                <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">生产实体</td>
                <td style="padding: 10px 15px; color: #334155;">[[杭州胡庆余堂]] (独家品种)•[[青春宝集团]] (关联)</td>
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                <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">治疗标签</td>
                <td style="padding: 10px 15px; color: #334155;">[[健脾活血]]•[[逆转萎缩]]•[[癌前病变阻断]]•[[国家中药保护品种]]</td>
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